Leukemia, which usually occurs because of a mutation — or DNA change — is the most common childhood cancer. Some genetic syndromes can create a predisposition to leukemia, as well as other blood disorders.
As scientists map ever more of the epigenetic disruptions that occur in cancer, the implications for cancer therapy are becoming increasingly evident.
Despite the fact that cancer survivorship is on the rise, it may seem that cancer is everywhere — and that there’s nothing we can do about it. But are we really powerless to stop certain cancers from coming our way? Or, at least, to lessen the chances of developing those […]
Gene, genetics, genome, and genomics all are derived from a Greek word – gen – meaning birth or origin. Almost every aspect of health and disease is influenced in some way by the inherited information in cells, written in the chemical code of DNA and packaged in distinct units known […]
Advances in genetic research may improve the prevention, diagnosis, and treatment of women’s cancers. “More genes are being found and fewer families are having to wonder if there is something genetic that may increase their risk, or future generations’ risk, of developing cancer,” says Judy Garber, MD, MPH, director of […]
Amy Kindstedt hates cancer, but the 9-year-old is very thankful for one thing: Because genetic testing on her baby brother Hunter revealed he had the same genetic mutation she did, his cancer was caught much earlier – possibly sparing him the same level of intense treatment she endured. The mapping […]
Knowledge of genetics and women’s cancers has come a long way in the 20 years since the BRCA1/2 genes were discovered. Scientists are able to identify more genes that can increase risk, leading to better prevention and improved treatment. “One of the most exciting developments is the knowledge that patients […]
By Christine Hensel Triantos On a cold winter day in 2002, Sharon Goyette stepped into Dana-Farber’s Center for Cancer Genetics and Prevention. She was a 21-year-old college student, and this was the last place she wanted to be. But her mother had insisted. After developing colon cancer, Goyette’s mother had […]
Twenty years ago, scientists announced the discovery of BRCA1, which arguably has become the best-known cancer susceptibility gene in the world. When inherited in a mutated form, the gene sharply increases a woman’s chances of developing breast or ovarian cancer, often at an early age. The discovery has changed the […]
Although most cancers are sporadic or occur by chance, a small percentage are due to inherited genetic (or germline) mutations, which can often be identified through genetic testing. These mutations are different from somatic mutations, which are not inherited, but occur during one’s lifetime. Profile, a research project launched by Dana-Farber […]
Breast cancer is the most common cancer among American women, but only 5-10 percent of breast cancer cases are hereditary. Of those cases, roughly 20-25 percent are linked to mutations in the BRCA1 and BRCA2 genes (BRCA stands for BReast CAncer susceptibility). View the infographic below for more on the […]
Win or lose, Miss America contestant Allyn Rose made news with her decision to undergo a double mastectomy. According to the Associated Press, Rose, who lost her mother to breast cancer, inherited a rare genetic mutation which might put her at greater risk for developing cancer. Her decision to have […]
The Encyclopedia Britannica may have published its last print edition, but a group of Dana-Farber scientists and their colleagues recently produced one of the first encyclopedias to help researchers determine which subtypes of cancer are likely to respond to current drugs. The freely available, online encyclopedia lists hundreds of cancer […]
Genetic testing provided a father and son with a proper diagnosis for their rare colon condition.
Methods of early detection can include cancer screening, which means to search for cancerous cells or tissue when no symptoms are present.
Researchers have established some of the main factors that can increase or decrease your overall cancer risk.
There are a number of steps people can take to reduce their risk of colon cancer, including screening and adjustments in diet and lifestyle.
Mutations in BRCA genes are linked to hereditary ovarian cancer as well as breast cancer.
Harmful BRCA mutations are uncommon in the general population. About one in every 500 women in the United States has either a BRCA1 or BRCA2 gene mutation.
Many factors contribute to increased breast cancer risk for some women — including certain inherited genes. About 5 to 10 percent of breast cancer cases are thought to be hereditary, meaning that they are the direct result of gene mutations passed on from a parent. Genes are individual units of […]