Dana-Farber's Geoffrey Shapiro, MD, PhD, answers common questions about clinical trials and how they help improve cancer treatment.
Researchers are applying the knowledge they’ve gained in previous clinical trials as they look into how immunotherapy might provide additional treatment options for patients with recurrent cervical cancer.
Each time the metastatic breast cancer spreads too deeply into Sayde Patel’s lungs, she changes clinical trials. And after six switches in 10 years, she maintains a glass-half-full attitude about the process.
Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested to determine if they are safe and effective for patients. Nearly all cancer drugs in use today were tested and made available to patients through clinical trials, making them a crucial component of […]
When a clinical trial shows that a new treatment is no better than the standard, it can be disappointing. But such outcomes yield valuable, potentially lifesaving information. Trials can “fail” if the experimental therapy doesn’t work better than current treatments. These “negative” outcomes are important for several reasons. They can […]
Better cancer treatments depend on clinical trials of new drugs and other therapies, but in the United States, only 3 percent of cancer patients participate in these investigations of new therapies. Patients often hesitate to participate because they don’t understand the process or have misconceptions about what it means for […]
Cancers of the vulva – the external portion of the female genitals – are diagnosed in approximately 4,700 women in the United States each year. While many patients can be cured by a combination of surgery, chemotherapy, and radiation therapy, others – particularly those whose cancer has metastasized to other […]
Current lymphoma therapies are a far cry from the mustard gas used more than 50 years ago. More treatment options, including ones that may be more effective and less toxic, are being studied in ongoing clinical trials. “Clinical trials really are the future of lymphoma treatment,” says Ann LaCasce, MD, […]
By Ian Krop, MD, PhD Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested in people to find out if they are safe and effective. Nearly all cancer drugs in use today were tested in clinical trials.
Keith Rohleder was diagnosed with a rare, aggressive blood cancer that most people have never heard of. But a new clinical trial put him into remission.
“Research” is a broad stroke of a word, the verbal equivalent of painting a wall instead of a masterpiece. There are important distinctions among the three principal types of medical research — basic, clinical and translational. Whereas basic research is looking at questions related to how nature works, translational research […]
This originally appeared on Vector, Boston Children’s Hospital’s blog. Adrenoleukodystrophy — depicted in the 1992 movie “Lorenzo’s Oil” — is a genetic disease that most severely affects boys. Caused by a defective gene on the X chromosome, it triggers a build-up of fatty acids that damage the protective myelin sheaths of the […]
Clinical trials are research studies that explore whether new treatments, diagnostic techniques, or disease-prevention strategies are safe and effective in patients. They may be an option when patients no longer benefit from standard therapies. They may also offer an alternative to standard therapies, particularly if the agent being tested is […]
As researchers and clinicians in the Susan F. Smith Center for Women’s Cancers at Dana-Farber continue studying the benefits of a two-drug combination in slowing progression of recurrent ovarian cancer, one patient is as a beacon of hope for her caregivers – and for others facing the disease. Betsy Brauser, […]
Kerri Antonuccio marked her 40th birthday this spring with a fresh lease on life. For the first time since 2012, she didn’t feel too sick from cancer treatment to enjoy her big day. She was also able to travel to Mexico and serve as matron of honor at her sister’s […]
When facing a diagnosis of metastatic breast cancer, patients often have many questions about clinical trials: Is a clinical trial right for me? When is a good time to consider a clinical trial? What types of treatments might be available? While there may be many questions about the process, the […]
Clinical trials are a key part of medical science’s effort to improve treatments for cancer patients. There are a variety of different types of trials, including therapeutic clinical trials, which test the safety and effectiveness of potential new agents in patients. Some patients participate in several therapeutic clinical trials, in […]
When Elizabeth Cahn was presented with her treatment options for triple-negative breast cancer, the decision was about more than just getting healthy; it was about “paying it forward.” “I know there are many people who participated in clinical trials before I came along and it was because of their participation […]
Nearly all cancer drugs in use today were developed through clinical trials. But before they are approved for use, they must go through multiple phases designed to test the drug’s safety and efficacy. These phases include preclinical, phase I, II, and III. In phase I clinical trials, investigators evaluate how […]
Findings from clinical trials have increased survival rates significantly in the last several decades for children with germ cell tumors.