Tag Archive for cervical cancer

DNA Test May Offer Alternative to Pap Smear

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A Food and Drug Administration (FDA) panel has recommended that a DNA test should be the primary screening tool for cervical cancer, rather than the traditional Pap smear. The DNA test detects the DNA of human papillomavirus (HPV), the sexually transmitted infection that causes almost all cases of cervical cancer.

“This is an important step forward for cervical cancer screening,” says Alexi Wright, MD, MPH, a medical oncologist in the Susan F. Smith Center for Women’s Cancers at Dana-Farber. Specifically, the DNA test screens for HPV-16 and HPV-18, the two highest-risk HPV strains, as well as 12 other high-risk HPV types, using a blood sample.

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Cervical Cancer Screenings: Five Things You Need to Know

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Ursula Matulonis, MD

Ursula Matulonis, MD

Approximately 10,000-11,000 women in the U.S. are diagnosed with cervical cancer every year. But with women having regular cervical cancer screenings, incidence and death rates from the disease have decreased by at least 80 percent in the U.S.

“Cervical cancer in the U.S. has become less of a frequently diagnosed cancer because of the institution of the Pap smear,” says Ursula Matulonis, MD, medical director of Gynecologic Oncology at the Susan F. Smith Center for Women’s Cancers at Dana-Farber.

As January marks Cervical Cancer Awareness Month, here are five important questions about cervical cancer screening:

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Study: Type of Cervical Cancer May Drive Treatment Choice

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By Alexi Wright, MD, MPH

Although there are two main types of cervical cancer, known as adenocarcinoma and squamous cell carcinoma, they’ve generally been treated as one disease, with the same approach to treatment. In a recent study, my colleagues and I surveyed the DNA in both types of cervical cancer cells to see if there were any differences. Such variations may help explain why the two types sometimes behave the way they do, and guide us toward treatments that work best in one type or the other.

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