The Truth About BRCA Testing and Genetic Risk

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Cancer genetics has come a long way in the last two decades, leading to increased prevention and improved treatment options. Today, research is shining the light on why certain people have an increased risk for cancer. “It took us 20 years to get where we are today with the knowledge of BRCA1/2, but we are starting to find changes in other genes that are explaining a history of cancer in families,” says Huma Q. Rana, MD, clinical director for Dana-Farber’s Center for Cancer Genetics and Prevention. “These new genes we’re identifying are likely to make a difference in prevention and …

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Five Things You Need to Know About Cancer Genetics

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Although most cancers are sporadic or occur by chance, a small percentage are due to inherited genetic (or germline) mutations, which can often be identified through genetic testing.  These mutations are different from somatic mutations, which are not inherited, but occur during one’s lifetime. Profile, a research project launched by Dana-Farber and Briigham and Women’s Hospital, has been analyzing DNA from tumor tissue since 2011 to learn more about how somatic mutations drive cancer. “Depending on family and personal history, we can test for genes that confer an increased risk for developing cancer,” says Huma Q. Rana, MD, clinical director for …

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Putting the Puzzle Pieces Together

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By Jenn Perry When I was diagnosed with breast cancer at 36, it was like déjà vu for my family. My mother had been diagnosed with the same disease at the same age, while pregnant with her third child. I learned I had breast cancer just six months after giving birth to my second daughter. My aunt also battled the disease, and my younger sister was diagnosed with a breast cancer very similar to the hormone-sensitive type I have. Although my sisters and I have been proactive about breast cancer screenings from a young age, genetic testing never crossed our …

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