A Food and Drug Administration (FDA) panel has recommended that a DNA test should be the primary screening tool for cervical cancer, rather than the traditional Pap smear. The DNA test detects the DNA of human papillomavirus (HPV), the sexually transmitted infection that causes almost all cases of cervical cancer.
“This is an important step forward for cervical cancer screening,” says Alexi Wright, MD, MPH, a medical oncologist in the Susan F. Smith Center for Women’s Cancers at Dana-Farber. Specifically, the DNA test screens for HPV-16 and HPV-18, the two highest-risk HPV strains, as well as 12 other high-risk HPV types, using a blood sample.
Ursula Matulonis, MD
Approximately 10,000-11,000 women in the U.S. are diagnosed with cervical cancer every year. But with women having regular cervical cancer screenings, incidence and death rates from the disease have decreased by at least 80 percent in the U.S.
“Cervical cancer in the U.S. has become less of a frequently diagnosed cancer because of the institution of the Pap smear,” says Ursula Matulonis, MD, medical director of Gynecologic Oncology at the Susan F. Smith Center for Women’s Cancers at Dana-Farber.
As January marks Cervical Cancer Awareness Month, here are five important questions about cervical cancer screening:
By Robert Haddad, MD
Human papillomavirus, or HPV, vaccinations were originally advised only for girls. The Centers for Disease Control and Prevention (CDC) and the American College of Pediatrics now recommend that both girls and boys be vaccinated. The recommendations are well founded: HPV infection is the number one cause of oropharyngeal cancer, which occurs in the middle part of the throat and is diagnosed in about 14,000 Americans each year. Men are three times more likely than women to develop oropharyngeal cancers linked to HPV.
Faced with an abundance of cancer stories in the news and our own personal experiences with cancer, we may fear that there’s a growing “epidemic” of the disease.
Not so. A new report says that overall, deaths from cancer are continuing to decline, as they have for nearly two decades. Read more
Traditionally, patients with oral cancers tended to be older individuals with a long history of smoking and heavy alcohol use. In the past decade, however, that picture has changed dramatically.
Today, infection with the human papillomavirus (HPV) is the leading cause of oropharyngeal cancer in the U.S. and Western Europe. Oropharyngeal cancers affect the back of the throat (i.e. the tonsils and base of the tongue). HPV is the same virus that causes most cases of cervical cancer in women.
Patients with HPV-related head and neck cancers are often relatively young, not heavy drinkers or smokers, and come from all segments of society.