Melanoma: Five Things You Need to Know

Stephen Hodi, MD

Although skin cancer is the most common cancer in the United States, melanoma accounts for less than 2 percent of all skin cancer cases. The disease, which will be diagnosed in around 76,000 Americans in 2014, is the most aggressive form of skin cancer. Melanoma begins in the melanocytes, which are found on the lower part of the epidermis. The disease can occur anywhere on the body and usually begins in a mole. “It is important that people protect themselves from the sun and make themselves aware of the signs and symptoms of melanoma to greatly reduce their risk of …

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Cancer Immunology at Dana-Farber

Immunotherapy – stimulating the body’s defenses to recognize and destroy disease-causing cells and proteins – was dubbed the “breakthrough of the year” in 2013 by Science magazine. Dana-Farber researchers have contributed many important discoveries over the years about how the immune system works. Now, they are building on these insights to develop immunotherapy against tumors – known as immuno-oncology. In 2005 Dana-Farber established the Cancer Vaccine Center (CVC) under the leadership of Ellis Reinherz, MD, Jerome Ritz, MD, and Glenn Dranoff, MD. The mission of the CVC is to translate the promising insights from basic immunology into therapeutics that benefit …

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New Strategies in Treating Kidney Cancer

By Richard Saltus  Though quite curable when diagnosed early, kidney cancer in advanced stages can become a stubborn disease. However, the outlook for patients with metastatic kidney cancer has brightened in the past several years. Oncologists have added to their arsenal a number of designer drugs that attack molecular targets – genetic abnormalities that drive tumors – with high specificity.

Ask the Expert: Questions and Answers about Brain Tumors

Dana-Farber Cancer Institute recently partnered with CancerConnect and Lakshmi Nayak, MD, to answer questions about brain cancer. Nayak is a neuro-oncologist in the Center for Neuro-Oncology at Dana-Farber/Brigham and Women’s Cancer Center and an instructor in neurology at Harvard Medical School.  Q: There seems to be some progress concerning treatment of brain tumors, especially immunotherapy. Do you think we will see further advancements in that area, or in other areas? A: Immunotherapy is indeed a hot topic in gliomas. This is largely driven by advances we have seen in the treatment of melanoma. The way these drugs work is to …

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What is immunotherapy for cancer?

Immunotherapy is one of the most technologically advanced yet basic forms of cancer treatment. It uses the body’s own defense mechanism, the immune system, to fight cancer. Immunotherapy is probably most familiar to you in the form of vaccinations for the flu, polio, chicken pox, and other contagious diseases. In those cases, people are injected with a dead or weakened form of the virus responsible for the disease. That prompts the immune system to produce antibodies and white blood cells that ward off infection from the live virus. For cancer prevention, two immune system-stimulating vaccines are now in use: one …

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