Promising Research Developments Stir Hopes for Melanoma, Lung, Breast and Ovarian Cancer

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The growing excitement about the potential of immunotherapy treatments for cancer continued at the 2015 meeting of the American Association for Cancer Research (AACR), one of the largest cancer research meetings of the year. Several Dana-Farber investigators presented encouraging results of immunotherapy for melanoma, lung cancer, and breast cancer. F. Stephen Hodi, MD, and Leena Gandhi, MD, gave reports on recently published results for immunotherapy trials in melanoma and lung cancer, respectively. Their findings were simultaneously published in the New England Journal of Medicine. “This field has changed a lot in the past few years and even in the past …

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Running Boston: ‘The Only Way I Know How’

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By Eric Kaye If you were living under a rock this winter… that is, a rock buried by seven feet of snow like most people around Boston, here is what you might have missed. The Patriots won the Super Bowl, Zayn Malik left One Direction, and Boston set an all-time record for snowfall. Also, somewhere hidden behind the snow banks that narrowed the city sidewalks, runners were training for the Boston Marathon. This is my 8th year repeating a ritual march from Hopkinton to Boston on the third Monday in April. All eight Boston Marathons run the only way I …

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Angelina Jolie Puts Spotlight on Genetic Testing and Ovarian Cancer Risk

Once again Angelina Jolie is making headlines after penning another op-ed in The New York Times. The actress shared she has undergone more cancer preventive surgery – this time prophylactic salpingo-oophorectomy, a procedure to have her ovaries and fallopian tubes removed. Two years ago, she wrote about her decision to have a prophylactic double mastectomy, a surgery to remove both breasts after her positive genetic test for the BRCA1 mutation. “It is not easy to make these decisions. But it is possible to take control and tackle head-on any health issue,” wrote Jolie. “You can seek advice, learn about the …

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Immunotherapy, Ovarian Cancer Treatment Top List of 2014 Cancer Developments

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Immunotherapy, treatments for ovarian cancer, and investigating game-changing drug therapies topped the list of the most important cancer research and clinical developments at Dana-Farber Cancer Institute in 2014. Here are some highlights from the last year in research: Hodgkin lymphoma Some of the most dramatic evidence of potential of immunotherapies was in the treatment of Hodgkin lymphoma. In an early-phase clinical trial, research showed nivolumab, a drug that unleashes the immune system to attack cancer cells, achieved complete or partial remissions in Hodgkin lymphoma patients with resistant forms of the disease. The success of nivolumab in this study prompted the …

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Tuukka Rask, Nutrition Tips, Brokaw on Cancer, and More Video Highlights from 2014

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As 2014 comes to a close, we’re taking a look back at some of our favorite videos from the last year:     Tom Brokaw: What it Means to Have Cancer NBC News’ Tom Brokaw, who was diagnosed with multiple myeloma in August 2013, stopped by Dana-Farber in November. We talked with him about his cancer experience and advice he has for fellow patients.   Why a Plant-Based Diet is Good for Your Health Eating a healthy, plant-based, balanced diet can help you manage your weight and may also help reduce your risk for developing certain cancers. Dana-Farber nutritionist Stacy …

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FDA Approves New Treatment for Advanced Ovarian Cancer

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The U.S. Food and Drug Administration (FDA) has approved a new treatment for women with advanced and recurrent ovarian cancer who test positive for the BRCA gene mutation. The new therapy, olaparib, will be used to treat women who have already received three or more lines of chemotherapy. The new therapy, which will be marketed under the name Lynparza, is a poly (ADP-ribose) polymerase – or PARP inhibitor – that hampers cancer cells’ ability to repair damaged DNA, potentially causing the cancer cells to die. Olaparib was approved along with a blood test called BRACAnalysis CDx that detects BRCA gene …

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BRCA-Positive Mom Supports Ovarian Cancer Research for Future Generations

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Mimi Gallagher never missed a gynecologist appointment. Her maternal grandmother died from ovarian cancer in her early 70s, and Gallagher, at 46, was well aware of her risk. Despite her diligence, and years of worry-free trips to the gynecologist, the mother of two was diagnosed with stage III c ovarian cancer. Troubling symptoms in July 2012, including bloating, constipation, and lethargy, led Gallagher to visit her gynecologist, primary care physician, and a gastrointestinal specialist, but, she says, “Ovarian cancer was never on anyone’s radar.” However, a vaginal ultrasound soon confirmed her cancer, and she was referred to a surgeon who …

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20 Years After BRCA: What We’ve Learned About Genetics and Breast Cancer

Twenty years ago, scientists announced the discovery of BRCA1, which arguably has become the best-known cancer susceptibility gene in the world. When inherited in a mutated form, the gene sharply increases a woman’s chances of developing breast or ovarian cancer, often at an early age. The discovery has changed the way women with a family history of breast and ovarian cancer approach these diseases, helping them better understand their risk and the options for reducing it. It also presents them with complex choices about sharing genetic test results with family members who may also carry the mutated gene. The hunt …

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Tips for Recovering from a Hysterectomy

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Hysterectomy, the surgical removal of the uterus, may be used to treat a variety of gynecologic cancers, including endometrial (uterine), ovarian, or cervical, or gestational trophoblastic  disease. Like any major surgery, recovering from a hysterectomy, which may also include removal of the ovaries, cervix, and fallopian tubes, takes time. Here is some advice from the Susan F. Smith Center for Women’s Cancers at Dana-Farber on recovering safely following a hysterectomy. Balance activity with rest. Walking is one of the best ways for the body to recover and heal. Start slow and always listen to your body. You may be more …

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New Drug Combination Shows Promise for Women with Recurrent Ovarian Cancer

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For many women with ovarian cancer that has returned after initial treatment, a two-drug combination can significantly extend the time that the disease is kept in check, according to a phase 2 clinical trial led by investigators at the Susan F. Smith Center for Women’s Cancers at Dana-Farber. As reported in Lancet Oncology, researchers compared the drugs cediranib and olaparib, versus olaparib alone, in their ability to stall the advance of ovarian cancer in women with a recurrent form of the disease that responds to platinum-based chemotherapy agents. The investigators found that the median period before the disease began to …

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