Study of Inherited Prostate Cancer Genetics in Africa Highlights Importance of Research

The genetic landscape of prostate cancer susceptibility in Africa is, like the continent itself, a picture of sweeping diversity, the largest study of the phenomenon concludes.  The findings, published in the journal Nature Genetics, are an important step in unravelling why prostate cancer rates are highest in men of African descent, whether they live in … Read more

What is the Role of Genetics in Lymphoma and Chronic Lymphocytic Leukemia?

Studies in large populations have shown that people who have a near relative with a form of lymphoma or chronic lymphocytic leukemia (CLL) have an increased risk of developing these diseases themselves. Both lymphoma and CLL are relatively uncommon: the average person’s lifetime risk of developing CLL, for example, is 0.57%, according to the American … Read more

Cancer Conversations Podcast—Episode #14—The Latest in Genetics and Women’s Cancers

Advances in genetic research may improve the prevention, diagnosis, and treatment of women’s cancers. “More genes are being found and fewer families are having to wonder if there is something genetic that may increase their risk, or future generations’ risk, of developing cancer,” says Judy Garber, MD, MPH, director of the Center for Cancer Genetics … Read more

How Genetics Can Help Predict — and Sometimes Stop — Childhood Cancers

Amy Kindstedt hates cancer, but the 9-year-old is very thankful for one thing: Because genetic testing on her baby brother Hunter revealed he had the same genetic mutation she did, his cancer was caught much earlier –  possibly sparing him the same level of intense treatment she endured. The mapping of the human genome has … Read more

20 Years After BRCA: What We’ve Learned About Genetics and Breast Cancer

Twenty years ago, scientists announced the discovery of BRCA1, which arguably has become the best-known cancer susceptibility gene in the world. When inherited in a mutated form, the gene sharply increases a woman’s chances of developing breast or ovarian cancer, often at an early age. The discovery has changed the way women with a family … Read more

Five Things You Need to Know About Cancer Genetics

Although most cancers are sporadic or occur by chance, a small percentage are due to inherited genetic (or germline) mutations, which can often be identified through genetic testing. These mutations are different from somatic mutations, which are not inherited, but occur during one’s lifetime. Profile, a research project launched by Dana-Farber and Brigham and Women’s Hospital, … Read more

Managing Cancer Risk: Miss America Contestant’s Decision Puts Genetics and Cancer Center Stage

Win or lose, Miss America contestant Allyn Rose made news with her decision to undergo a double mastectomy. According to the Associated Press, Rose, who lost her mother to breast cancer, inherited a rare genetic mutation which might put her at greater risk for developing cancer. Her decision to have the preventive surgery has sparked … Read more

Lynch Syndrome Center Guides Family Throughout Cancer Journey 

The Scragg family always knew it was a possibility, but it still came as a shock.  It was August 2021, and Mark Scragg, then 33, was undergoing treatment for stage 4 stomach cancer. After just three months of chemotherapy and immunotherapy, scans showed no sign of the tumor first discovered in his stomach that spring … Read more

What You Need to Know About Rising Pancreatic Cancer Rates 

A recent analysis of pancreatic cancer statistics in the United States has found that the incidence of pancreatic cancer is increasing faster in younger adults than among older adults. Though this finding is cause for further investigation, the incidence overall remains low.   “This is still a rare cancer in young people,” says Asaf Maoz, MD, … Read more

Patient Takes Steps Toward Proactive Care Following Three Cancer Diagnoses 

Elizabeth Johnston, then 37, was healthy and busy with two young children and a blossoming career running a public relations firm in Connecticut. One of her clients is the Hartford Marathon Foundation and in 2015, she decided to start running smaller stretches herself.   “I was in the best shape of my life,” Johnston recalls.   Little … Read more

Lynch Syndrome Center Helps Family Stay Vigilant — and Grow 

The first time Jay Reese was diagnosed with colon cancer, he didn’t tell his preschool-aged children. After it came back decades later, he told them immediately — and then suggested they take action.   Jay underwent genetic testing after his 2012 colon cancer recurrence which revealed he had Lynch syndrome, an inherited genetic condition which carries … Read more

Prostate Cancer Risk and Screening: Five Things You Need to Know  

Prostate cancer is the most common cancer diagnosed in men. When found early, before it has spread, patients can do extremely well.  However, prostate cancer risks vary due to genetics, health care access, socioeconomics, and environmental exposures. Some groups have higher risks and worse outcomes. For example:  The best way to improve your chances of … Read more