For a long time, the standard treatment for younger patients with newly diagnosed mantle cell lymphoma involved intensive chemotherapy, called induction therapy, followed by autologous stem cell transplant (ASCT, where the patient’s own stem cells are used), followed by maintenance therapy to help keep the cancer from coming back. Based on recent clinical research involving … Read more
After nearly nine years of living with follicular lymphoma, a type of non-Hodgkin lymphoma (NHL), it took just a few minutes for things to change dramatically for Marc Cummings this spring. That was all the time needed to transfer the small bag of modified CAR T-cells — which had been recrafted from Cummings’ own T … Read more
Championship rower Dan Lynch is used to fighting against the current. Most people start the sport in their teens or twenties. Lynch dropped oars at 53 on a whim. Today, it isn’t a mere hobby. He’s now pursuing the longest-known streak of consecutive days on an indoor rowing machine. Not even mantle cell lymphoma, a … Read more
Two years ago, with a new wife and large extended family on his mind, Jose Dos Anjos told caregivers he would do anything to help himself and others facing the aggressive, life-threatening blood cancer known as mantle cell lymphoma (MCL). Now, thanks in part to this willingness, he and fellow MCL patients have renewed hope … Read more
Mantle cell lymphoma is a rare, often aggressive form of non-Hodgkin lymphoma (NHL), a cancer that involves white blood cells known as lymphocytes, which help protect the body from disease. It is named for its origins in the mantle zone — a ring of cells within the lymph nodes where B cells (a type of … Read more
Precursor conditions are early phases of diseases that may develop into cancers such as lymphoma, leukemia, Waldenström’s macroglobulinemia, and multiple myeloma. Most people with precursor conditions do not experience symptoms, and since doctors rarely screen for these conditions, they are sometimes found through routine blood tests but often remain undiagnosed. “Many diagnoses are purely incidental,” says Irene Ghobrial, MD, director … Read more
CAR T-cell therapy—a form of immunotherapy that uses genetically engineered T cells to intensify the immune system’s response to cancer—represents one of the biggest advances against cancer in recent years.