Cancer Genetics

Angelina Jolie Puts Spotlight on Genetic Testing and Ovarian Cancer Risk

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Once again Angelina Jolie is making headlines after penning another op-ed in The New York Times. The actress shared she has undergone more cancer preventive surgery – this time prophylactic salpingo-oophorectomy, a procedure to have her ovaries and fallopian tubes removed. Two years ago, she wrote about her decision to have a prophylactic double mastectomy, … Read more

20 Years After BRCA: What We’ve Learned About Genetics and Breast Cancer

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Twenty years ago, scientists announced the discovery of BRCA1, which arguably has become the best-known cancer susceptibility gene in the world. When inherited in a mutated form, the gene sharply increases a woman’s chances of developing breast or ovarian cancer, often at an early age. The discovery has changed the way women with a family … Read more

Five Things You Need to Know About Cancer Genetics

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Although most cancers are sporadic or occur by chance, a small percentage are due to inherited genetic (or germline) mutations, which can often be identified through genetic testing. These mutations are different from somatic mutations, which are not inherited, but occur during one’s lifetime. Profile, a research project launched by Dana-Farber and Brigham and Women’s Hospital, … Read more

Tips for Talking to Your Children About Genetic Test Results

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There are many decisions parents face after testing for genetic cancer risk, including whether to tell their children and how to approach the conversation.

If you decide to talk to your children about the test results, allow yourself some time to process the information; you want to be calm and clear when you talk with them. Remember that you know your children best and there are no set rules for talking to kids about genetic tests.

You also may want to talk with your spouse and decide whether you would like to speak with the children together or individually. It is good to be aware that sometimes spontaneous discussion opportunities arise – such as driving a child to school or practice – when a child asks a question that can disrupt parents’ plans for informing them, but can feel like a natural way for the topic to come up and be talked about.

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Outsmart Your Genes: Understanding BRCA1/2 Cancer Risk

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When Angelina Jolie underwent a preventative double mastectomy earlier this year, this issue of cancer risk and genetics made front-page headlines. Jolie, who announced the operation in a New York Times op-ed, tested positive for the BRCA1 gene mutation and learned she had an 87 percent risk of developing breast cancer.

Jolie’s announcement left many women wanting to know more: What is a gene mutation? Should I undergo genetic testing? What should I do if my tests are positive?

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Genetic Testing, Cancer Risk, and Angelina Jolie’s Choice

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Actress Angelina Jolie is no stranger to the headlines, but she stunned the world with her Op-Ed in The New York Times, in which she shared her very private decision to have a preventive double mastectomy after testing positive for the BRCA1 gene mutation. “I hope that other women can benefit from my experience,” wrote Jolie. … Read more

Managing Cancer Risk: Miss America Contestant’s Decision Puts Genetics and Cancer Center Stage

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Win or lose, Miss America contestant Allyn Rose made news with her decision to undergo a double mastectomy. According to the Associated Press, Rose, who lost her mother to breast cancer, inherited a rare genetic mutation which might put her at greater risk for developing cancer.

Her decision to have the preventive surgery has sparked questions about genetics, cancer risk and strategies for preventing cancer.

If you have a question about genetic factors that increase cancer risk, you can ask the Dana-Farber cancer genetics team.

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How are Genes Involved in Cancer?

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Genes don’t cause cancer, but genetic mutations can. Our cells have about 22,000 genes, which consist of DNA packed into chromosomes inside the cell nucleus. These genes control a wide range of functions, including cell growth and division. When the genes misbehave or mutate, cancer can develop. Sometimes these mutations are inherited. In that case, … Read more

Genetic counseling now recommended for children with sarcoma

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If your son or daughter has been diagnosed with a type of sarcoma – a tumor in connective tissue like muscles or bones – there are many questions: Will my child make a full recovery? What are the immediate and long-term side effects of treatment?

Most parents don’t consider whether their child will face a second cancer later in life.

However, a link between sarcomas and Li-Fraumeni syndrome, a rare condition that raises a person’s risk of developing one or more cancers to as high as 85 percent, has led genetic specialists at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center to recommend that all child sarcoma patients be offered genetic counseling for Li-Fraumeni syndrome. 

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