Catch Me if You Can: Finding Cancer Cells that Hide in Plain Sight

In the high-stakes contest of hide-and-seek between cancer cells and the human immune system, the advantage doesn’t always lie with the body’s defenders. A new approach to treatment, known as CAR T-cell therapy, may shift that balance of power. Cancer cells conceal themselves from the immune system not by barricading themselves in an impenetrable shell, … Read more

Immunotherapy Beats Chemotherapy for Advanced Bladder Cancer Patients

The immunotherapy drug pembrolizumab (Keytruda) is the first therapy of any kind to improve survival in patients whose metastatic bladder cancer worsened after treatment with platinum-based chemotherapy. Keytruda proved so much better than chemotherapy in this “second-line” use that an international clinical trial was halted when the advantage became apparent. “This is very good news; … Read more

What Is CTLA-4 and How Does it Work in Treating Metastatic Melanoma?

Since the early 2000s, when Dana-Farber scientists discovered that many cancer cells carry “checkpoint” proteins that ward off an immune system attack on tumors, a great deal of research has focused on the development and testing of agents capable of blocking those proteins. In many patients, such agents have sent cancers into long-term remissions. A checkpoint … Read more