Targeting Triple-Negative Breast Cancer

Breast cancer may develop in one part of the body, but it’s not just one disease. In fact, oncologists think of breast cancer as at least three different types of diseases.

Erica Mayer, MD, MPH

Triple-negative breast cancer (TNBC) describes breast cancer cells that do not have estrogen, progesterone, or HER2 receptors. It makes up approximately 15 percent of all breast cancers and is typically more aggressive than the other two types, estrogen receptor-positive breast cancer and HER2-positive breast cancer.

“It may be the smallest group, but TNBC still represents thousands of women with breast cancer, so it is a very important group for us,” says Erica Mayer, MD, MPH, a medical oncologist at Dana-Farber’s Susan F. Smith Center for Women’s Cancers.

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Study: Type of Cervical Cancer May Drive Treatment Choice

By Alexi Wright, MD, MPH

Although there are two main types of cervical cancer, known as adenocarcinoma and squamous cell carcinoma, they’ve generally been treated as one disease, with the same approach to treatment. In a recent study, my colleagues and I surveyed the DNA in both types of cervical cancer cells to see if there were any differences. Such variations may help explain why the two types sometimes behave the way they do, and guide us toward treatments that work best in one type or the other.

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Foods to Keep in Your Diet Before and After a Mastectomy

During cancer treatment, a nutritious and well-rounded diet can help you cope with side effects of chemotherapy, maintain energy and support the immune system. If you are preparing for a mastectomy or other major surgery, a healthy diet will also provide nutrients to help optimize healing time.

Most patients who undergo a mastectomy can return to regular eating habits two weeks after the surgery, but nutritionists recommend a healthy diet to be ideally implemented before the procedure to help you heal and set up long-term healthy eating habits. There are several foods we suggest make it to your plate both before and after the procedure:

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Four Lessons from a Cancer Caregiver

In June 2001, my wife, Angela Palmer, was diagnosed with stage 2 breast cancer while we were living in Tucson, Arizona. This was a huge shock. She had annual mammograms and never had any indications of disease.

Patrick and Angela Palmer
Angela and Patrick Palmer

She had a lumpectomy and completed about 50 percent of her chemotherapy protocol before we moved to the northeast where our family was located. We arrived in Boston in December 2001, bought a house and became engaged with a tremendous Dana-Farber team including Wendy Chen, MD, MPH, medical oncologist and Jennifer Bellon, MD, radiation oncologist. Angela immediately resumed her therapy and I became her caregiver.

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Giving Platelets – and Hope – to Cancer Patients

Ninety minutes. That’s all it takes to save a life when you donate platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and Women’s Hospital. For Baila Janock, these 90 minutes are practically a weekly occurrence since her late husband Irving Janock was treated for pancreatic cancer at Dana-Farber in the mid-1980s.

Last summer, after more than 30 years of volunteering at Dana-Farber and making more than 200 platelet donations, Janock joined “Team 20” yet again – an honor bestowed upon donors who give platelets more than 20 times in a year.

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How to Tell Your Children You Have Cancer

For many parents, their first concern after a cancer diagnosis is the impact it will have on their children. There’s a lot of medical information to digest and decisions to be made, including how and when to tell your children.

There are good reasons talk to your children as soon as possible after your diagnosis. No matter their age, children will realize something is wrong; they may discover the truth accidentally from someone else, and it’s better if you can present the information in an honest and hopeful manner.

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One Year After My Stem Cell Transplant — What I’ve Learned

by Martha Laperle

When my son Ryan ran the Boston Marathon this year, I watched him with a special level of pride. Not only had he completed his first-ever marathon in four hours, but he was running, in large part, because of me.

Just over a year earlier, at the age of 57, I had been diagnosed with an aggressive form of acute myeloid leukemia (AML), a diagnosis that turned my life upside down and led to weeks of chemotherapy and a stem cell transplant at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC). Ryan was running to raise funds for the Leukemia & Lymphoma Society and had received nearly $11,000 in pledges.

Barely a minute after Ryan crossed the finish line, the area shook with explosions.

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What is Personalized Medicine?

Physicians have long recognized that the same disease can behave differently from one patient to another, and that there is no one-size-fits-all treatment.

In cancer, chemotherapy might dramatically shrink one lung tumor but prove ineffective against the same type of tumor in a different patient – even though tissue samples look identical under the microscope. Side effects and appropriate dosage may vary from patient to patient as well.

The goal of personalized medicine is to match a treatment to the unique characteristics of an individual patient: his or her personal and family medical history, age, body size, and other physical characteristics, and medical test results. But fundamentally, it is the DNA blueprint within cells that strongly influences a person’s risks of disease, how illnesses play out, which drugs are likely to be most effective and with the fewest side effects. This is where the newest phase of personalized medicine is heading.

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Drinking in Early Adulthood Can Increase Breast Cancer Risk

Women who believe that drinking moderate amounts of alcohol won’t increase their risk of breast cancer may want to think again.

Last year, Wendy Chen, MD, of the Susan F. Smith Center for Women’s Cancers at Dana-Farber and her colleagues published a study showing that women who drank as little as three to six glasses of wine or other alcoholic beverages a week increased their breast cancer risk by about 15 percent.

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Six Important Questions About Childhood Cancer

September is Childhood Cancer Awareness Month. We asked Lisa Diller, MD, chief medical officer at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, to answer these important questions.

What signs might lead a child’s pediatrician to suspect cancer?

Cancer is very diverse, and diagnosis is further complicated because many signs and symptoms—like fever, bruising and headaches—are normal in healthy children.

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Ask the Expert: Questions and Answers about Ovarian Cancer

Dana-Farber Cancer Institute recently partnered with CancerConnect and Ursula Matulonis, MD, to answer questions about ovarian cancer. Experts in the Susan F. Smith Center for Women’s Cancers offer the latest research and treatment for this type of cancer. Watch one patient’s story.

Q: Is taking curcumin recommended to prevent ovarian cancer from returning? Do you have any other suggestions for preventing recurrence?

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Making ‘Em Laugh: 12-year-old Cancer Patient Compiles Joke Book

Jack Robinson is a special kid.

Diagnosed with bone cancer at the age of 11, he tackled treatment if not with a smile on his face, then with a joke on his lips… or more accurately, on paper. The Massachusetts resident compiled and edited a joke book called, “Make ‘em Laugh” to help himself, and other kids who were sick. It was drafted from hundreds of jokes, riddles, and drawings submitted by Robinson and other kids cared for in the Jimmy Fund Clinic and the inpatient oncology floors at Boston Children’s Hospital.

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When Should My Daughter Get Her First Pap Test?

By Sarah Feldman, MD, MPH

Pap testHealthy young women should get their first Pap test at age 21. If that test is normal, they should have additional Pap tests every three years. If they have symptoms such as abnormal bleeding or are found to have an abnormality on their cervix during an exam, they may need a diagnostic Pap for cervical cancer earlier. Immunosuppressed women should start Pap testing with the onset of sexual activity, then repeat annually.

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Teen Patient Uses Images to Document Cancer Treatment

Rayquan “Ray” Fregeau’s smile lights up a room, even after five days of chemotherapy. His upbeat personality infuses his poetry, but until recently the 17-year-old patient at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center had trouble putting into words what he’s gone through since his February cancer diagnosis, especially when it came to telling friends about his experience.

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What is the Difference Between Palliative Care and Hospice?

Although the terms are often used interchangeably, palliative care and hospice care differ in several important ways for cancer patients – most notably, the stage of treatment at which they are given. Both types of care focus on relieving patients’ pain and discomfort, whether caused by the cancer itself or the side effects of treatment. … Read more

Dating and Cancer 101

SWF, Bald, Undergoing Chemo and Radiation…

Oh yeah, isn’t that the first profile you would click on if you were searching for the love of your life or even just a new ‘friend’ online? Dating in itself – or, I should say, finding someone to date – is never easy. Finding someone when you happen to be bald, going through chemo and/or making daily trips to the hospital for radiation makes it a zillion times more complicated. I know. I’ve tried it.

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