New Study: Chemo Before Surgery Avoids Need for Mastectomy for Many with Triple-Negative Breast Cancer

0

Chemotherapy before surgery shrank triple-negative breast tumors in women in a clinical trial to the point where half of those who had not been eligible for breast-conserving surgery became eligible for it, according to investigators at Dana-Farber and Brigham and Women’s Hospital. The findings were reported at the American Surgical Association annual meeting and in a study in the journal Annals of Surgery.

Mehra Golshan, MD, director of Breast Surgical Services with the Susan F. Smith Center for Women's Cancers at Dana-Farber, speaks with a patient.

Mehra Golshan, MD, director of Breast Surgical Services with the Susan F. Smith Center for Women’s Cancers at Dana-Farber, speaks with a patient.

The study involved 400 women participating in a phase 2 clinical trial of a combination chemotherapy regimen for triple-negative breast cancer, a malignancy whose cells lack receptors for the hormones estrogen and progesterone, and the protein HER2. The trial, organized by the Alliance for Clinical Trials in Oncology, examined whether adding the chemotherapy agent carboplatin and/or the angiogenesis inhibitor bevacizumab to standard therapy would cause the tumors to disappear or decrease in size.

Before receiving the drug therapy, 46 percent of the patients weren’t considered candidates for breast-conserving therapy – their tumors were so large that treatment would require removal of the entire breast. After completing the chemotherapy, 42 percent of those patients had so much tumor shrinkage that they were eligible for breast-conserving therapy. The breast-conserving surgery was successful in 93 percent of those who chose it.

Even with this success rate, 31 percent of those who qualified for breast-conserving therapy ultimately decided to have a mastectomy – a rather high percentage considering that a major purpose of pre-surgical chemotherapy is to make breast-conserving surgery available to more patients.

“It’s unclear whether patients are opting for mastectomy because of their own bias, a bias on their surgeon’s part, or because of genetics or other factors,” said Mehra Golshan, MD, of Dana-Farber/Brigham and Women’s Cancer Center and director of Breast Surgical Services at the Susan F. Smith Center for Women’s Cancers at Dana-Farber, lead author of the study. “This is an area where more investigation is needed.”

Make An Appointment

For adults: 877-960-1562

Quick access: Appointments as soon as the next day for new adult patients

For children: 888-733-4662

Latest Tweets

Dana-Farber @danafarber
What is a benign tumor and what is a malignant #tumor? We explain on the blog: https://t.co/4kL8YFnw5H https://t.co/IEzvBwm0VX
Dana-Farber @danafarber
The @WEEI/@NESN Jimmy Fund Radio-Telethon is LIVE from @fenwaypark on August 21 and 22! Tune to hear our patients’… https://t.co/pa0ZNJxAvv
Dana-Farber @danafarber
How Giving Hand Massages to Cancer Patients Helps Them – And Me, Too: https://t.co/AwZnt71PgM #volunteering https://t.co/sGJuWLKHvX

Patient and Family Blogs

Patients and families of patients at Dana-Farber often chronicle their own experiences with cancer.

Here are some blogs that you can follow.