Symptoms of Inflammatory Breast Cancer: Fact or Fiction

By Beth Overmoyer, MD

Inflammatory breast cancer is a rare but aggressive form of breast cancer that affects young women more than older women. Because it’s relatively uncommon — it represents less than five percent of all breast cancer cases — people are often confused about what inflammatory breast cancer is and how you can detect it.

As a breast oncologist specializing in inflammatory breast cancer, I want to share some of the common myths to help you separate fact from fiction about the disease.

Dr. Beth Overmoyer (left).

FICTION: If there’s no lump, there’s no cancer.

Unlike other types of breast cancer, which are detected with a mass or lump in the breast, inflammatory breast cancer may be detected without a lump. Symptoms of inflammatory breast cancer can include:

  • Pain or itchiness of the breast
  • Redness of the breast
  • Swelling or enlargement of the breast
  • Swelling of the lymph nodes in the armpit or above/below the collarbone
  • Thickening of the skin of the breast or ridged or dimpled skin texture (sometimes called peau d’orange, because it looks like the skin of an orange)

FACT: Inflammatory breast cancer is often misdiagnosed as an infection.

Many of the symptoms of inflammatory breast cancer are similar to the symptoms of an infection called mastitis. This similarity can complicate the diagnosis. Mastitis is treated with antibiotics, but if symptoms don’t improve after a few days on antibiotics, you should talk to an oncologist who specializes in inflammatory breast cancer.

FACT: There are effective treatments for inflammatory breast cancer.

As with many cancers, early detection is important to effective treatment. If you are concerned that you may have symptoms, don’t wait. See your doctor.

Because inflammatory breast cancer involves the breast as well as the blood stream, the primary treatment is chemotherapy. There are some targeted therapies — angiogenesis drugs that target the blood vessels that cancers need to grow, and Herceptin, which targets the HER2 subtype of breast cancer, for example — that have been very effective in treating inflammatory breast cancer.

After we get the maximum effect from chemotherapy, the next step is surgery. Unfortunately, inflammatory breast cancer involves the entire breast. It doesn’t just show up as a lump in one part of the breast but involves the lymphatics, which are channels that run around and through the breast. So the surgery that we need to do is a mastectomy. We then follow up with radiation to take care of any residual cancer that may be in the chest wall or in the lymph node groups.

This combination of treatment — chemotherapy, mastectomy and radiation therapy — has significantly improved survival, but more work is needed to understand this disease.

FICTION: If I have a mastectomy as part of my treatment for inflammatory breast cancer, I can’t have breast reconstruction.

While we recommend that patients wait for six to twelve months before they have breast reconstruction, it is an option for women who have had inflammatory breast cancer.

FICTION: Because inflammatory breast cancer is rare, there is not a lot of focus on research.

There is a great deal of research underway. Last year, I was awarded a grant from the Inflammatory Breast Cancer Research Foundation to study inflammatory breast cancer. We are working on a new clinical trial specifically targeting this type of breast cancer and one of the important pathways that stimulates cancer growth. In addition, we have a clinical trial for newly diagnosed inflammatory breast cancer which includes one of the important new drugs targeting HER2. Our clinical trials always include a scientific component in order to improve our understanding of this virulent disease.

Dr. Beth Overmoyer is a physician at Dana-Farber Cancer Institute and director of the Inflammatory Breast Cancer Program.

4 thoughts on “Symptoms of Inflammatory Breast Cancer: Fact or Fiction”

  1. Pingback: Anonymous
  2. This was a very informative post. Have there been a good number of breast cancer clinical trials outside of the Dana-Farber Cancer Institute which have had IBC as their primary focus? I would certainly be interested in hearing more about these new drugs which are targeting HER2.

    • Hi Steve:

      Some additional input from Dr. Overmoyer:

      There have been very few clinical trials devoted to IBC internationally because of the rarity of the disease. Two studies did include many IBC patients though; one (the NOAH trial) showed the benefit of adding Herceptin to chemotherapy pre-operatively. No other study has used the newer drugs to treat HER2 positive IBC except our study with pertuzumab.


  3. Hi Steve:
    Thanks for the comment. For clinical trials outside of Dana-Farber, you might want to visit the National Cancer Institute’s site and specifically,

    The site “is a registry and results database of federally and privately supported clinical trials conducted in the United States and around the world.”

    You can also search for clinical trials at Dana-Farber at

Comments are closed.