When breast cancer metastasizes, it often heads for the brain, where it can be exceptionally difficult to root out. The key to preventing the spread of the cancer, or thwarting it if it does reach the brain, is to understand the mechanism that turns stationary tumor cells into nomadic intruders. In a recent study, a … Read more
A white patient looking for a stem cell donor has about a 75% chance of finding a fully-matched unrelated donor in the U.S. NMDP Registry. A fully matched donor has the same human leukocyte antigen (HLA) type, a set of eight genetic variables that dictate how the immune system communicates. Finding a fully matched donor … Read more
Jim Omel, MD, helped many cancer patients during his long career as a family physician, and that has not changed since his own 1997 diagnosis with multiple myeloma. What has changed is the reach of his support. While Omel, 77, cared for primarily farming families near his Nebraska clinic during 25-plus years in practice, his … Read more
Dana-Farber researcher Charles Stiles, PhD, remembers the call. It was 2008 and a colleague phoned from a conference to deliver the news. Two separate research teams had discovered a genetic driver for the most common of childhood brain tumors called pediatric low-grade glioma. The problem of finding a genetic target to improve treatment for this … Read more
An exercise-related hormone, irisin, administered to animals with a model of Parkinson’s disease reduced nerve degeneration and symptoms associated with the progressive movement disorder, say scientists from Dana-Farber and Johns Hopkins Medicine. About one million people in the United States, and 10 million people worldwide are living with Parkinson’s, which is characterized by tremors, slowed … Read more