Like many teenagers with cancer, Declan Cassidy, 16, has endured having his life interrupted by surgery, chemotherapy infusions, and other treatments. In his case, however, the greatest ongoing challenge goes beyond the cancer itself. Declan is legally blind, the result of an optic pathway glioma — a slow-growing brain tumor that forms in and around the optic nerves connecting the eye to the brain. … Read more
In 2014, Dana-Farber pediatric oncologist Brian Crompton, MD, discovered that a gene called STAG2 is mutated in about 15 percent of patients with Ewing sarcoma, a form of bone cancer that largely occurs in children and adolescents. Now, that molecular insight could hold the keys to advancing treatment for the disease. New research led by senior authors Crompton and pediatric oncologist Katherine Janeway, MD, Dana-Farber Pediatric Oncology Section Chief and Chair of the Children’s … Read more
The walk is a little different each day, sometimes a twisting, turning path through the various side streets of Boston’s Longwood Medical Area, and on other occasions more of a straight line down bustling thoroughfares. One thing, though, remains consistent: no matter which route Paris Prinsen, 21, takes from her apartment to classes at the … Read more
Nolan Young has aspirations of a career in both the Air Force and FBI, and even at age 15 it’s easy to imagine him achieving these goals. After all, when you’ve already endured the rigors of chemotherapy, radiation, emergency surgeries, and a stem cell transplant for T-cell acute lymphoblastic leukemia (T-ALL) — all before high … Read more
Gene therapy and immunotherapy are both types of treatment for cancer and other diseases. They represent different approaches to disease therapy, though there is some overlap. What is gene therapy? Gene therapy is a way of treating or preventing disease by altering the genetic instructions within an individual’s cells. Most diseases aren’t caused by a … Read more
With the Boston Red Sox having their best season in years and contending for the playoffs, crowds have been regularly filling Fenway Park to capacity this summer. For one small contingent of these baseball fans, the trips will prove especially meaningful regardless of what transpires on the field. This rotating group, mostly young children and … Read more
The Dana-Farber lab of Kira Bona, MD, MPH, has uncovered an alarming reality: children from low-income households are more likely to experience cancer relapse and face lower survival rates compared to their more privileged peers, despite receiving treatment on highly standardized clinical trials at top academic centers. The number of children for whom these data … Read more
Physician-scientist Franziska Wachter, MD, came to Dana-Farber 10 years ago as a postdoctoral fellow with a vision. In the clinic, she cares for children with hard-to-treat cases of acute myeloid leukemia (AML). In the laboratory, her eyes are on the molecular drivers of the disease. “I try to connect the two roles as much as … Read more
In Catherine Argyrople’s “Growing Pains,” a scene set on a sunny day at a high school pool party becomes a way to explore how pediatric cancer can affect teenagers in survivorship. The protagonist, a curly-haired highschooler named Zoe wears a bikini for the first time in her life, revealing a scar on her stomach. A … Read more
Dana-Farber researcher Charles Stiles, PhD, remembers the call. It was 2008 and a colleague phoned from a conference to deliver the news. Two separate research teams had discovered a genetic driver for the most common of childhood brain tumors called pediatric low-grade glioma. The problem of finding a genetic target to improve treatment for this … Read more
Patti Keenan was a senior in high school before learning that the mysterious disease she was treated for twice as a young girl in the 60s was, in fact, a rare form of cancer. Her parents, not wanting to frighten Patti at a time when pediatric cancer survival rates were much lower, kept their daughter’s … Read more
Jake Maguire was just three days away from his sixth birthday when he was diagnosed with acute lymphoblastic leukemia (ALL). Encouraged by his father, a gym teacher, the young Maguire was already in love with sports, especially baseball. Now 23 and over a decade out of treatment, that love is still strong, and Maguire is … Read more
She may be an accomplished competitive skier, but Maggie Gove, 15, is just as adept at getting up and over mountains as she is racing down them. Gove is a three-time cancer survivor who has managed to keep up on the slopes and with her studies despite long periods sidelined by surgery, chemotherapy, and radiation … Read more
A study led by Dana-Farber researchers has revealed that inherited variations in certain DNA damage repair genes may increase an individual’s susceptibility to Ewing sarcoma, an aggressive cancer that tends to strike teenagers and young adults. Ewing sarcoma is rare, with only about one in a million cases diagnosed annually in the United States, and … Read more
Two major obstacles once stood in the way of exploring the basic biology of diffuse midline glioma in children. And one of them was the brain itself. The cancer, a subtype of high-grade glioma, forms in some of the most critical parts of the brain, in regions that control such basic functions as breathing, swallowing, … Read more
Results of several phase 3 trials and dozens of other studies led by Dana-Farber researchers were presented online and in person June 3-7 at the 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO), the world’s largest clinical cancer research meeting. Some of the research reports presented by Dana-Farber investigators include: Improved progression-free … Read more
Most teenagers can’t wait to grow up. At 19, Sara Almheiri was initially deemed too old — at least by the physicians who first diagnosed her with cancer. Complaining of terrible bellyaches that baffled doctors in her native Dubai, part of the United Arab Emirates (UAE), Sara had traveled in late 2016 to South Korea, … Read more
Approximately one in three children in the United States lives in a low-income home. For childhood cancer patients, living in a low-income home can have a significant impact: Poverty and associated factors are linked to poorer outcomes, even at large academic medical centers like Dana-Farber, according to research by Kira Bona, MD, MPH, a pediatric … Read more
Asked how he has dealt with three bouts of bone cancer and a partial right leg amputation in less than four years, 14-year-old Jack Berry says that he takes things “one step at a time.” That is, when he’s not surfing, riding his mountain bike, sprinting across tennis courts, or winning ski races. An osteosarcoma … Read more
Investigators had culled the list of suspects down to two. But which one was the guilty party, or were both? The pair worked together so seamlessly, it was difficult to tell where one’s role began and the other’s ended. In some respects, they even looked alike. Dana-Farber scientists have now teased apart the relationship between … Read more