Pediatric Leukemia Patient Takes LEAP to Remission on Precision Medicine Trial

First Cinthia Roman Manrique learned she had acute lymphoblastic leukemia (ALL). Then the 8-year-old Peru native was uprooted from her school, family, and friends when she flew with her mother in early 2017 to the United States — where chances of a cure for her high-risk cancer were better.  In the U.S., Cinthia’s challenges continued … Read more

A Decade Later, Pediatric Cancer Survivor Shares His Experience

Brian Regan knows how overwhelming it can be to hear the words “you have cancer” as a teenager. That is why, nearly a decade after his own diagnosis, he feels compelled to help young patients and families currently grappling with the physical and emotional challenges of treatment. Regan, 27, is a member of the Pediatric … Read more

Pediatric Patient with Leukemia in Remission after Treatment and Transplant

Rosemary Iwakura, 17, was experiencing strange symptoms before her acute lymphoblastic leukemia diagnosis (ALL) almost two years ago. She was unable to focus on her schoolwork or activities and fainted on several occasions at school and at home. “I thought; ‘People faint for many reasons,’” she recalls. “We weren’t sure if we were supposed to … Read more

Pediatric Patient with Rare Leukemia in Remission after Novel Treatment

Nytasha Jette was panicked when her two-month-old son, Elyahs Jones, was found to have an extraordinarily high white blood cell count — over 300,000 — during a regular check-up. The family physician noted that Jones had very pale hands and was worried that the child wasn’t getting proper blood flow. Jette rushed Jones to Dana-Farber/Boston … Read more

Surviving Stem Cell Transplant: New Hope When the Donor Isn’t a Full Match

To see Tara Daniels today, with a corporate job in marketing and about to close on a house, you’d never know what she’s been through, how thrilled she is to be alive. This month marks five years since she received a high-risk bone marrow transplant for a life-threatening blood cancer. Tara woke up feeling sick … Read more

Researchers Solve Mystery of Retinoic Acid’s Potency Against High-Risk Neuroblastoma

For decades, retinoic acid has been a key part of the arsenal against the childhood cancer neuroblastoma. For just as long, scientists have wondered exactly how it works. The answer, Dana-Farber researchers have found, is by reprogramming the activity of two crucial pairs of genes with such precision that the drug almost seems to have … Read more

What Causes Bone Cancer?

Cancers originating in the bone, called primary bone cancers, are rare and account for less than 1% of all cancers. There are numerous types of primary bone cancers, and in most cases, the cause isn’t known. Primary bone tumors can have changes in the DNA of the cancer cells, but those DNA changes are acquired … Read more

Teenager Gets Back to ‘Regular Life’ After Cancer Treatment

How did teenager Noah Zierfus stay grounded in the face of a cancer diagnosis? With his perfect trifecta of family, friends, and football. The Springfield, Vermont native was a junior in high school when he noticed he had something like a cyst. The doctors told him it was nothing at first, but Noah and his … Read more

For Families of Children with Cancer, A New Focus on Hereditary Risk

Widespread testing of pediatric tumors has confirmed a long-held suspicion: far more of them have hereditary roots than was once thought. Physicians and researchers now estimate that at least 10% of cancers in children and adolescents, and probably many more, are linked to hereditary genetic mutations that increase cancer risk. The findings have changed the … Read more

After Wilms Tumor Treatment, First Grade is First Rate for Pediatric Cancer Survivor

The last two school years will be remembered for the tremendous challenges they presented students due to COVID-19, but rising second-grader Caroline McMahan and her family were ready for the pandemic’s limitations after what they had already endured. By the time the pandemic began, Caroline, 7, was already adept at washing up, masking up, and … Read more

Newborn Genetic Screening for Pediatric Cancer Risk Could Save Lives

Numerous genetic mutations increase children’s risk for various cancers. When they are detected early, cancers can potentially be caught at an early, more treatable stage — or avoided entirely. Could adding such “cancer predisposition” genes to routine newborn “heel-stick” screening save lives? Lisa Diller, MD, chief medical officer at the Dana-Farber/Boston Children’s Cancer and Blood … Read more