Scientists Reveal How Lung Cancer Cancer Cells Avoid Death from Targeted Drugs

Perhaps the biggest challenge in precision cancer therapy is tumors’ nasty habit of rebounding after an initial attack with targeted drugs has shrunk them almost out of existence. Instead of vanishing completely, curing the patient, the tumors leave behind a small cadre of cells that slumber in a dormant state, only to return in a … Continued

New Studies Show Promise in Treatment of NUT Carcinoma

Medically reviewed by Geoffrey Shapiro, MD, PhD, and Christopher French, MD Although it is one of the most aggressive solid tumors in humans, NUT carcinoma responds better to treatment in some patients than others. But because it is rare — with only 20 to 30 cases diagnosed annually in the United States — doctors have … Continued

What is Mantle Cell Lymphoma and How Is It Treated?

Medically reviewed by Ann S. LaCasce, MD, MMSc Mantle cell lymphoma is a rare, often aggressive form of non-Hodgkin lymphoma (NHL), a cancer that involves white blood cells known as lymphocytes, which help protect the body from disease. It is named for its origins in the mantle zone — a ring of cells within the … Continued

Multiple Myeloma Fails to Keep Football Player-Turned-Broadcaster Out of Action

Many sports stars have helped support research and care at Dana-Farber by appearing on the WEEI/NESN Jimmy Fund Radio-Telethon presented by Arbella Insurance Foundation, but few have done so quite like pro football wide receiver-turned-broadcaster Jimmy Cefalo. When Cefalo was interviewed on-air during the August 2019 event at Fenway Park, he used the opportunity to share some … Continued

Anal Cancer: What You Need to Know

Medically reviewed by Douglas Rubinson, MD, PhD Anal cancer is a type of cancer that forms in tissues of the anus. The anus is the opening of the rectum to the outside of the body and at the end of the gastrointestinal tract. What is the leading theory on why the incidence rate has risen … Continued

What Does a Thyroid Cancer Lump Feel Like?

Medically reviewed by Jochen H. Lorch, MD, MS While 80 to 90 percent of reported thyroid lumps are not cancerous, performing “neck checks” can help you become familiar with what your thyroid looks and feels like, so you can tell your health care professional if you notice any changes. Jochen Lorch, MD, director of the … Continued

What Are the Differences Between Lymphocytic and Myelogenous Leukemia?

Medically reviewed by Martha Wadleigh, MD Leukemia arises from malfunctions in stem cells within the bone marrow that cause abnormal white blood cells to flood into the bloodstream. Leukemias are classified as either myelogenous (also called myeloid) or lymphocytic, depending on which types of white blood cells are affected. What is the difference between these types … Continued

Nobel Prize Research Was a Winning Formula for Patient with Kidney Cancer

Early on an October morning, Shaun Tierney started a promising new treatment for his stage IV kidney cancer. Anxious to tell his longtime oncologist, he texted Toni Choueiri, MD, director of the Lank Center for Genitourinary Oncology at Dana-Farber. What he didn’t expect was that Choueiri would have his own big news: “Kaelin … Nobel … Continued

How Long Does Chemotherapy Stay in Your Body?

Chemotherapy agents are powerful drugs that are used to treat cancer throughout the body. Chemotherapy drugs work by a variety of different mechanisms, but their general effect is to slow or stop the growth of cancer cells, which divide and proliferate quickly. Chemotherapy is administrated with the intention of eliminating cancer cells so that the infected body can survive … Continued

What’s the Difference Between Melanoma and Skin Cancer?

Melanoma is not a different disease from skin cancer. It is, rather, a form of skin cancer. Of the three major forms of skin cancer, melanoma is the rarest but also the most aggressive. It is diagnosed in more than 96,000 people in the United States each year, and patients generally have a good prognosis … Continued

Young Investigators Use Patient Samples for Cancer Studies

In their search for better treatments for breast, ovarian, and other cancers, young investigators Jennifer Guerriero, PhD, and Sarah Hill, MD, PhD, rely on a precious commodity — patient tissue samples obtained by surgeons in Dana-Farber’s Susan F. Smith Center for Women’s Cancers. Studies of these normal and cancerous tissues, which are collected, banked, and … Continued

Adult Leukemia: What You Need to Know

Medically reviewed by Richard M. Stone, MD More than 60,000 new cases of adult leukemia are diagnosed in the U.S. each year. Although it is one of the more common childhood cancers, leukemia occurs more often in older adults. How does leukemia develop in adults? Leukemia is a cancer of the body’s blood-forming tissues that results in large … Continued

Five Things You Need to Know About Barrett’s Esophagus

Medically reviewed by Peter C. Enzinger, MD Barrett’s esophagus is a complication of gastroesophageal reflux disease, or GERD, and can sometimes be a precursor for esophageal cancer. The condition occurs when the tissue lining the esophagus (the tube that carries food from the mouth to the stomach) begins to resemble tissue that lines the intestines … Continued

After Cancer Treatment, Former Ironman Participant Finds Strength Again

Consisting of a 2.4-mile swim, a 112-mile bike ride, and a 26.2-mile run, an Ironman Triathlon is not for the faint of heart — and completing it is a feat worth celebrating. After conquering the race, Dan Luers believed he was ready for whatever life had in store. Nothing could have prepared him for a … Continued

What Are the Most Common Blood Cancers in Adults?

Medically reviewed by Ann S. LaCasce, MD, MMSc Non-Hodgkin lymphoma Non-Hodgkin lymphoma (NHL) is a type of cancer that forms in the lymph system, part of the body’s immune system. There are many kinds of NHL that develop from various types of white blood cells, including B cells, T cells, and NK cells. The majority … Continued

How Can I Tell the Difference Between Irritable Bowel Syndrome and Colorectal Cancer?

Medically reviewed by Jeffrey A. Meyerhardt, MD, MPH Irritable bowel syndrome (IBS) is a chronic disorder in which the large intestine undergoes abnormal contractions, producing abdominal pain, cramps, diarrhea, constipation, or a mix of these symptoms. (It is a different condition from inflammatory bowel disease (IBD), which most often occurs as ulcerative colitis or Crohn’s … Continued