Immunotherapy is Lifesaver for Firefighter with Rare Bile Duct Cancer

As a former volunteer firefighter, Paul Calnan prided himself on being ready for any emergency. He thought nothing could rattle him — until, at age 47, doctors discovered a large, malignant tumor in his liver. The diagnosis was stage IV intrahepatic cholangiocarcinoma, a rare form of bile duct cancer that had presented in Calnan’s liver. … Read more

Combination Therapy Working Well for Patient with Cervical Cancer in Clinical Trial

Just as the COVID-19 pandemic was sending entire states into lockdown, Jill Bailey learned that her metastatic cervical cancer was beginning to break free of the grip of chemotherapy. It was March 2020. Scans showed that Bailey’s metastatic tumors, which had shrunk in response to chemotherapy and another drug, were slowly starting to grow. A … Read more

Patient with Cancer Shares Tips for Being Your Biggest Advocate

Life is like a Mad-Lib, and Jennifer White is taking control of what she can fill in the blank spaces. The Atlanta-based cyber security consultant was diagnosed with chronic lymphocytic leukemia (CLL) in January 2019. In July of that same year, White, a Boston native, came to Dana-Farber. She currently comes to Boston four times … Read more

What is an Atypical Mole?

Atypical moles are irregular moles that can appear anywhere on the body. They are more commonly found on people with fair skin, as well as those with many freckles and moles on the body (more than 50). What do atypical moles look like? In order to spot atypical moles or something more serious, dermatologists recommend … Read more

What is Nasopharyngeal Cancer?

Nasopharyngeal cancer (NPC) is a type of throat cancer that forms in the nasopharynx, which is the upper part of the throat behind the nose. It is part of the passageway for the air from the nose to travel to the lungs. Nasopharyngeal cancer is rare, though it can occur at any age. In the … Read more

New ‘Druggable’ Genetic Targets Identified in Rare Type of Bile Duct Cancer

Scientists are beginning to make inroads into treating cholangiocarcinoma, a rare, lethal cancer of the bile ducts, with precision drugs. Last year, the first targeted drug for some patients with the disease was approved. Now, Dana-Farber scientists say they have identified another genetic alteration in a small percentage of cholangiocarcinoma patients that can be attacked … Read more

Study Reveals Promising Combination Therapy for T-Cell Prolymphocytic Leukemia

Cancer cells have a bias toward survival, often becoming heavily reliant on certain protein pathways to sustain themselves. Scientists are finding ways to turn that survival instinct into a liability — by making the cells even more dependent on those pathways, then choking the pathways off. It’s an approach that has now yielded a promising … Read more

Dramatic Turns, Epiphanies Mark Patient’s Journey with Colorectal Cancer

Khiem Tran’s response to drug therapy for advanced colorectal cancer seemed to defy the severity of his disease. After just a few doses of chemotherapy and a targeted drug, the cancer, which had spread from his rectum to his liver, was in full retreat, with a key marker of tumor burden dropping from stratospheric levels … Read more

Cracking the Case of an Attorney’s HER2-Positive Breast Cancer

Joy Albi has encountered plenty of surprises during her long career as a defense attorney, but she was still caught off-guard when her HER2-positive breast cancer diagnosis took an unexpected twist last year. The way things turned out, however, made her appreciative for the new evidence revealed in her case. Albi, a Cincinnati resident, had … Read more

Glioblastoma Patient Enjoys Steady Health and New Adventures

If you happened to be looking for Alex Epshteyn this past winter, you might have found him on the ski slopes. The Charlestown, Massachusetts resident took up the sport just two years ago and has since been enthusiastically sharpening his skills. “I’m overcoming my fear and making progress, which is a great feeling,” Epshteyn says. … Read more

Study Uncovers Potent Immunotherapy Approach to Ovarian Cancer Treatment

Immune therapies declare open season on cancer, rousing immune system cells to take up an attack on tumors. But which immune cells join the hunt, which sit it out, and what happens within immune cells that causes them to go on the offensive? Such questions are especially relevant when immunotherapies show only limited effectiveness against … Read more