Study Reveals Promising Combination Therapy for T-Cell Prolymphocytic Leukemia

Cancer cells have a bias toward survival, often becoming heavily reliant on certain protein pathways to sustain themselves. Scientists are finding ways to turn that survival instinct into a liability — by making the cells even more dependent on those pathways, then choking the pathways off. It’s an approach that has now yielded a promising … Continued

Dramatic Turns, Epiphanies Mark Patient’s Journey with Colorectal Cancer

Khiem Tran’s response to drug therapy for advanced colorectal cancer seemed to defy the severity of his disease. After just a few doses of chemotherapy and a targeted drug, the cancer, which had spread from his rectum to his liver, was in full retreat, with a key marker of tumor burden dropping from stratospheric levels … Continued

Cracking the Case of an Attorney’s HER2-Positive Breast Cancer

Joy Albi has encountered plenty of surprises during her long career as a defense attorney, but she was still caught off-guard when her HER2-positive breast cancer diagnosis took an unexpected twist last year. The way things turned out, however, made her appreciative for the new evidence revealed in her case. Albi, a Cincinnati resident, had … Continued

Colorectal Cancer in the Black Community: Information to Know

Communities of color, particularly Black Americans, have long faced health disparities and a disproportionate burden of cancer. Colorectal cancer is no exception. Colorectal cancer occurs at a higher rate in Black Americans than any other racial or ethnic group in the U.S., according to the American Cancer Society. African Americans are more than 20% more … Continued

Rizwan Romee, MD: A Researcher Fascinated with the Immune System

Rizwan Romee, MD, is a medical oncologist at Dana-Farber and treats patients with advanced blood cancers such as leukemia and myelodysplastic syndrome. He is also the director of the Haploidentical Stem Cell Transplantation Program at Dana-Farber and principal investigator of the Romee Lab for NK Cell Gene Manipulation and Therapy. Why did you decide to … Continued

How is Rectal Cancer Different from Colon Cancer?

Cancers of the colon and rectum are often lumped together as “colorectal cancer” because they have many features in common. However, there are important differences in the structure of the colon and rectum and how cancers of each behave and are treated. What is the difference between the colon and the rectum? The colon, or … Continued

Glioblastoma Patient Enjoys Steady Health and New Adventures

If you happened to be looking for Alex Epshteyn this past winter, you might have found him on the ski slopes. The Charlestown, Massachusetts resident took up the sport just two years ago and has since been enthusiastically sharpening his skills. “I’m overcoming my fear and making progress, which is a great feeling,” Epshteyn says. … Continued

Study Uncovers Potent Immunotherapy Approach to Ovarian Cancer Treatment

Immune therapies declare open season on cancer, rousing immune system cells to take up an attack on tumors. But which immune cells join the hunt, which sit it out, and what happens within immune cells that causes them to go on the offensive? Such questions are especially relevant when immunotherapies show only limited effectiveness against … Continued

Dana-Farber Opens New Doors for Patient Battling Metastatic Colon Cancer

Paul Rawate has never been one to sit still. Whether it was getting his blackbelt in Taekwondo at just 8 years old or growing up to run a successful business, the 45-year-old has always kept his eye on the next challenge. In 2018, Rawate faced an entirely new obstacle when he was diagnosed with metastatic … Continued

What is Paget Disease of the Breast?

Paget disease of the breast occurs when cancer cells within the breast grow along the sides of the milk ducts and exit onto the skin of the nipple and surrounding circle of skin called the areola. It can arise at any age associated with breast cancer and usually involves a single breast. Although the hallmarks … Continued

What are TILs and How Are They Used in Cancer Treatment?

A form of immune cell therapy for cancer known as tumor infiltrating lymphocyte, or TIL, therapy, involves removing immune T cells from a piece of the patient’s tumor — where the T cells have succeeded in recognizing the cancer — expanding them outside the body, and re-infusing them by the billions to fight the disease. … Continued

Young Father Gets the Cancer Treatment He Needs During COVID-19

Chris Devin never expected to be diagnosed with multiple myeloma at the age of 45 — and being told he had cancer during the COVID-19 pandemic was far from ideal.  But Devin quickly learned that he could rely on his team at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) for the best treatment options. While COVID-19 … Continued

EGFR-Mutant Lung Cancer: What You Need to Know

While most lung cancers are linked to tobacco smoking, a minority — about 15 percent in the United States — of non-small cell lung cancers are driven by a random mutation in a gene called EGFR, which helps cells grow and divide. What is EGFR-mutant lung cancer? A mutation in the gene EGFR, which stands … Continued

What is Richter’s Syndrome and How is it Treated?

Richter’s syndrome involves the rapid transformation of chronic lymphocytic leukemia (CLL) into a significantly more aggressive form of lymphoma, usually diffuse large B-cell lymphoma (DLBCL), but occasionally Hodgkin lymphoma (HL). It arises in 2-10% of all patients with CLL and can occur at any time in the course of the disease. The goal of treatment … Continued

Metastatic Colon Cancer Patient Still Enjoying Each Special Moment

New England may be known for its harsh weather, but it’s never stopped Kyle Vinson from getting out and doing what he loves. An avid skier and golfer, the Massachusetts resident prides himself on once doing both in the same day. When he was diagnosed with metastatic colon cancer in 2020, the 38-year-old had to … Continued

ER-Positive Breast Cancer: What’s the Latest in Treatment?

Harold J. Burstein, MD, PhD, physician-scientist in the Breast Oncology Program of the Susan F. Smith Center for Women’s Cancers, provided an update on treatment of ER-positive breast cancer, including the roles of chemotherapy, targeted therapy, and ovarian suppression, in a recent New England Journal of Medicine article. What is ER-positive breast cancer? Of the … Continued

Metastatic Uterine Cancer Patient Remains Optimistic With Help of Care Team

Stephanie Davis is a master adapter. When she was initially diagnosed with serous uterine cancer, she found a way to continue working around surgery, radiation, and chemotherapy. Today, she is still adapting — moving from one treatment plan to another as her cancer changes — and is in consultation with her care team to keep … Continued