Dana-Farber Research

Three Recent Dana-Farber Research Studies to Know About  

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Every year, physician researchers at Dana-Farber Cancer Institute reveal new treatments, protocols, and outcomes that advance cancer research. At one of this year’s biggest cancer research conferences, the European Society for Medical Oncology (ESMO) Congress in Berlin, Germany, Dana-Farber researchers presented 22 studies in breast, lung, and bladder cancer.  Here are three of the most exciting advancements — several nearing U.S. Food and Drug Administration (FDA) approval — shared by our experts nearly 4,000 miles across the world.  An oral therapy for advanced breast cancer   Erica Mayer, MD, MPH, director … Read more

Forcing Cancer to Grow Up: Dana-Farber Scientists Reprogram Tumors to Behave Normally  

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Cancer can make its way through the body by shapeshifting through even the narrowest places, like a skilled driver navigating traffic. It has a sly way of adapting to its environment by finding detours around every blockade clinicians place in its path.   A study from the lab of Nilay Sethi, MD, PhD, in Dana-Farber’s Center … Read more

Three Ways Research Could Improve Pancreatic Cancer Treatment 

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Pancreatic cancer has long been difficult to detect and treat. Dana-Farber experts in the  Hale Family Center for Pancreatic Cancer Research, however, are working to change that with research efforts in three key areas that are poised to advance early detection, early intervention, and treatment of the disease.   They presented these topics for discussion with … Read more

Dana-Farber Research Uncovers Potential Targeted Therapy for Endometrial Cancer 

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Jessica St. Laurent, MD, was sure something had gone wrong. The results of an experiment she’d run showed that the cancer cells she was studying had abnormally high levels of a specific collection of proteins of interest to her team.  “I remember seeing the gradient and thinking, This can’t be right,” says St. Laurent, who … Read more

Dana-Farber Treats First Patient with Approved Gene Therapy for Beta Thalassemia 

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A few years ago, Oscar Diep, a 33-year-old software engineer living in Weymouth, Mass., started needing blood transfusions more often to manage a blood disorder called beta thalassemia. He also noticed that it was becoming harder for the nurses to find a vein for his infusions.  On top of this, Diep and his then girlfriend, … Read more

Dana-Farber Researchers Find Less Treatment May be More in Mantle Cell Lymphoma 

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For a long time, the standard treatment for younger patients with newly diagnosed mantle cell lymphoma involved intensive chemotherapy, called induction therapy, followed by autologous stem cell transplant (ASCT, where the patient’s own stem cells are used), followed by maintenance therapy to help keep the cancer from coming back.   Based on recent clinical research involving … Read more

TILs: What Are They and How Are They Used in Cancer Treatment?

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What is TIL (tumor-infiltrating lymphocyte) therapy? Tumor-infiltrating lymphocyte, or TIL, therapy uses a patient’s own immune system T cells to fight cancer. The therapy involves removing T cells from a piece of the patient’s tumor – where the T cells have congregated after being alerted to the cancer – growing them outside the body, then … Read more

New Insights into Immunotherapy Targets for Pancreatic Cancer 

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Cancer research often focuses on gene mutations in the parts of the human genome that produce cellular machinery called proteins. But the rest of the genome — sometimes called the “dark genome” — can also play a role.   Dana-Farber researcher William Freed-Pastor, MD, PhD, a physician-scientist in the Dana-Farber Center for Gastrointestinal Oncology and Hale … Read more

What is Immunopeptidomics? 

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A burgeoning type of “omics” called immunopeptidomics is providing researchers with a powerful approach to discovering new ways to train a person’s immune system to fight cancer.  In cancer research, the approach is being used to take an inventory of every flag on the surface of a cancer cell and determine what it is, if … Read more

Years of Research Help Forge a New Path in Hodgkin Lymphoma Treatment  

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Medical advances tend to unfold slowly over many years, fueled by successive clinical studies that build upon each other and together provide the evidence needed to change patient care. A key illustration of this point comes from a recent phase 3 clinical trial, published last October in the New England Journal of Medicine (NEJM), which … Read more

A Year of Advances in Genitourinary Cancer 

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Dana-Farber’s genitourinary cancer team is devoted to research that will advance patient care and improve patient’s lives. Recently, that research — all of it years in the making — has paid off with major achievements.  This includes:  “We are constantly striving to improve the treatment and diagnosis of genitourinary cancers,” says Toni Choueiri, MD, director … Read more

What is a Menin Inhibitor?

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Menin, a protein located in the nucleus of various human cell types, often functions as a tumor suppressor by inhibiting excessive cell growth and division. It facilitates a complex of proteins involved in a cellular process called histone methylation, where chemical units called methyl groups are added to histone proteins that anchor DNA, thereby activating … Read more

Expanding Options for Patients with Ovarian Cancer 

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In 2021, a novel drug called belzutifan was approved by the U.S. Food and Drug Administration (FDA) to treat clear cell renal cell carcinoma, a form of kidney cancer. Since then, Dana-Farber clinical investigator Panos Konstantinopoulos, MD, PhD, has wanted to launch a clinical trial of the drug for clear cell ovarian cancer.  That vision … Read more

What’s on My Slide? What Pathologists See and Learn Under the Microscope 

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Pathologists at Dana-Farber analyze tumor samples from tissues collected from patients as part of research studies. Their goal is to learn as much as possible about the sample so that they determine the best way to diagnose the disease precisely and guide treatment decisions.  As research advances, more and more factors are influencing diagnoses and … Read more

Understanding the Spread of Science Misinformation  

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According to a new report, misinformation about science and health can lead individuals to make ill-informed decisions that aren’t in their best interest. It also has broader effects in society by causing confusion and eroding trust in institutions, including scientific institutions.  Over the past two-plus years, a panel of scientific investigators gathered by the National Academies … Read more