Simone Ledward-Boseman has many roles: She’s a writer, artist, and singer. And for some time, she was a caregiver to her late husband, Chadwick Boseman, the actor known for playing Black Panther and groundbreaking figures like James Brown and Jackie Robinson. These days, Ledward-Boseman has added more titles to her list: activist and advocate. “I’m … Read more
GERD, which stands for gastroesophageal reflux disease, occurs when stomach acid repeatedly flows back up the esophagus, the tube connecting the mouth to the stomach. This irritates the lining of the esophagus, causing heartburn and, in some cases, an influx of stomach acid into the throat and mouth. Occasional GERD — also known as acid … Read more
For a while, Stephanie Dobson attributed her gastrointestinal issues to her pregnancy. It was her second, a girl born in May 2023, a baby sister to her son. But when the symptoms persisted for the 34-year-old mother, she raised the issue with her primary care provider. She was encouraged to see a gastroenterologist. On an … Read more
Dana-Farber researchers have found that a transcription factor called SOX17 gives colon cancer a safe space to develop.
Stories of young adults being diagnosed with colorectal cancer are becoming more common as the rates continue to rise among adults between 20 and 49.
Physicians have long known that there is a link between diabetes and pancreatic cancer.
Colon and rectal cancer combined are the fourth most commonly diagnosed cancers. Eighty percent of patients are diagnosed at a stage of disease when treatment is given with curative-intent. However, treatment can have both short- and long-term side effects that may impact quality of life. To address these concerns, investigators at Dana-Farber have led clinical … Read more
As a cancer imaging fellow at Dana-Farber, Michael Rosenthal, MD, PhD, spent about two years working on a radiologist’s version of paint-by-number. Together with his colleagues, he annotated 687 computed tomography (CT) scans, manually differentiating skeletal muscle from fat tissue by labelling them with different colors. The work was part of a 2018 project to … Read more
Wind up a mechanical mouse, set it down, and watch it go. New research by Dana-Farber scientists shows that boosting a single protein in the liver can have the same animating effect in real mice. The protein, called MIC19, produces changes deep inside liver cells that help the body burn nutrients, protecting against obesity and … Read more
Anal cancer is a highly preventable type of cancer given its connection to human papillomavirus (HPV), a group of 150 related viruses that infect the surface of the skin, which can include the genitals, anus, mouth and throat. The majority of squamous cell anal cancers (the most common form of anal cancer which affects the … Read more
Anal cancer, which forms in tissues of the anus, the opening at the bottom of the rectum, is diagnosed in about 9,800 people each year in the United States, most often in older adults. It is more common in white women and Black men than other groups, and while it is a serious disease, it … Read more
People who inherit mutations in the BRCA1 or BRCA2 gene are at heightened risk for a variety of cancers, including breast, ovarian, prostate, and pancreatic. It’s estimated that one in 300-400 people in the general population carry a mutation in either of these genes. Among people of Ashkenazi (Eastern European) Jewish descent, the prevalence is … Read more
Two weeks after turning 50, Wendy Tamis Robbins learned she had stage II colon cancer. Having lived with anxiety, obsessive compulsive disorder, and panic disorders nearly all her life, she used the same strategies that helped her navigate these struggles to meet her cancer diagnosis head-on. Robbins handled the ups and downs of her summer … Read more
Pancreatic cancer often eludes early detection because symptoms typically don’t surface until the disease is well established. This makes it important to respond appropriately to warning signs, even though some may be vague or caused by another health condition. What are the symptoms of pancreatic cancer? Most symptoms of pancreatic cancer are caused when tumors … Read more
For years, patients with advanced forms of gastric and esophageal cancer have had relatively few treatment options. Most patients with inoperable tumors would receive chemotherapy, usually a combination of fluorouracil, oxaliplatin and leucovorin (known as FOLFOX). While this regimen is often effective, patients eventually develop resistance to the treatment and their tumors progress. Now, the … Read more
Although hemorrhoids and colon cancer share certain symptoms, such as rectal bleeding, they are very different conditions. People who experience symptoms of either should get evaluated by a physician: while hemorrhoids are far more common than colon cancer, an exam is necessary to determine which one, if either, a patient has and how it should … Read more
For close to a year, Melanie Spears had been experiencing abdominal pain and constipation. As an Army veteran who had served in Afghanistan, she was used to pushing through adversity — so she tweaked her diet and dealt with what doctors diagnosed as irritable bowel syndrome. Only after microscopic blood samples in her stool led … Read more
Researchers in the late 1970s wanted to address challenges with a chemotherapy drug called floxuridine. It’s a form of chemotherapy invented in the 1950s that turns into its active form, 5-fluorouracil, or 5-FU, when metabolized. One challenge is that 5-FU has off-target effects, meaning it can damage healthy organs when given throughout the body. In … Read more
After losing her first husband of 30 years to cancer, Candace “Candy” Langford felt blessed to find love again. And when she learned six weeks after her June 2018 wedding that she had locally advanced pancreatic cancer, shock blended with sorrow — because she knew her new life partner had also been down that road … Read more
Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. All cells in the body recycle minerals and nutrients, removing them from storage and breaking them down them for re-use. But in cancer cells, this process, known as autophagy — literally, … Read more