When Will Verbits noticed a cut on the side of his foot in the summer of 2024, he wasn’t worried. The longtime administrator of special education assumed he’d somehow gotten a blister. He was happily looking forward to retirement, eager to brush up on his cooking skills. But, over time, a lesion developed and grew. … Read more
On his 75th birthday, when most people would be celebrating, William Scimone received some of the worst news of his life: he had anal cancer. It was a devastating blow, but having watched his mother battle lung cancer years earlier, Scimone knew three things: he needed the best care available, he needed the support of … Read more
New medicines called RAS inhibitors are dramatically changing the way pancreatic cancer will be treated over the coming years. They are a beacon of hope for patients with the disease. There are several oral RAS inhibitors for pancreatic cancer in late phase clinical trials, including one that has been given an initial regulatory green light … Read more
Anal cancer is a cluster of abnormal cells that grow in the anal canal and may appear like firm lumps or bumps, an open sore, or wart-like. Those who are infected with the human papillomavirus (HPV) are more likely to develop anal cancer, among other types of cancer, such as cervical and head and neck cancers. HPV refers to a large … Read more
As she got out of the car and waved goodbye to her husband and her mother, Margaret-Ann Simonetta’s shoulders stiffened with anxiety. It was April 2021, still in the height of the COVID-19 pandemic, and she was headed into Brigham and Women’s Hospital for a colectomy – a total surgical removal of her colon. With … Read more
Cancer treatment has evolved dramatically in the first quarter of this century, but there is still much more to do to improve the lives of people with cancer. At Dana-Farber, research continues in the clinic and in the lab in efforts to continue to bring advancements in treatment and prevention for patients. That research has resulted in exciting … Read more
If you look down at your stomach, glide your eyes diagonally from your belly button to the lower right side of your abdomen: that’s your appendix. It is a finger-shaped organ that stems from your colon. With two primary functions — supporting the immune system and potentially serving as a safe house for good bacteria, as theorized from some– the appendix is a small, but mighty organ that is important to take note of, especially given the recent … Read more
Feeling constipated? You may not be getting enough fiber in your diet. Fiber-rich diets are a key component to preventing and reducing constipation and can help you maintain a healthy gut. Dietary fiber offers many health benefits from reducing chronic diseases like diabetes to lowering your risk of some types of cancer, such as colorectal cancer. Fiber is an undigested nutrient that passes through the body when you consume fruits, vegetables, … Read more
Cancer can make its way through the body by shapeshifting through even the narrowest places, like a skilled driver navigating traffic. It has a sly way of adapting to its environment by finding detours around every blockade clinicians place in its path. A study from the lab of Nilay Sethi, MD, PhD, in Dana-Farber’s Center … Read more
Pancreatic cancer has long been difficult to detect and treat, but that might be changing. Dana-Farber experts in the Hale Family Center for Pancreatic Cancer Research are focused on three key areas that are poised to shift the way people think about, treat, and detect pancreatic cancer. Research shows the effectiveness of RAS therapeutics for pancreatic cancer The introduction of medicines that target a … Read more
Tammy Hshieh, MD, MPH, is the lead geriatrician for geriatric oncology at Dana-Farber, working with the programs for Older Adults with Hematologic Malignancy, Older Adults with Breast Cancer, and Older Adults with Gastrointestinal Cancers. As a physician-scientist, her research focuses on promoting healthier aging and improving cognition and function as well as understanding and preventing … Read more
Marsha Olsen’s grandmother always used to say, “You have one body, take good care of it.” And for most of her life, Olsen has spread that message as a middle school physical education and health teacher instilling healthy habits in her students. “I wanted all my students to have a positive experience in physical education, … Read more
When Clelia Lavoie, then 49, began experiencing abdominal pain in 2019, she had a feeling it was something serious despite dismissals from her doctor. Lavoie’s intuition was right. A colonoscopy led to a diagnosis of stage IV colorectal cancer that had metastasized to her thyroid, back, and liver. She needed surgery to remove part of … Read more
Editor’s Note: Kathy Ball-Toncic completed her 162-mile PMC ride on Aug. 2-3, 2025. Since sharing her story, Kathy has continued to inspire others, including through her recent TEDx talk, “When Life Disrupts: Choosing Connection Over Fear,” where she reflects on survivorship, resilience, and the importance of showing up for one another. Nearly 1,300 cyclists will be … Read more
Cancer research often focuses on gene mutations in the parts of the human genome that produce cellular machinery called proteins. But the rest of the genome — sometimes called the “dark genome” — can also play a role. Dana-Farber researcher William Freed-Pastor, MD, PhD, a physician-scientist in the Dana-Farber Center for Gastrointestinal Oncology and Hale … Read more
Dana-Farber’s Older Adult Gastrointestinal Cancer Program specializes in treating patients who are 65 and older and have gastrointestinal cancers, such as colorectal cancer, esophageal and gastric cancer, liver cancer, neuroendocrine and pancreatic cancer. “Older adults are richly complex and multidimensional,” says gastrointestinal and geriatric oncologist Nadine McCleary, MD, MPH, who leads the program. “They deserve … Read more
In recent decades, rates of some cancers, such as colorectal cancer, have been rising in young adults under the age of 50. One possible explanation for this rise is a parallel rise in obesity rates and changes in diet, activity levels and lifestyle. However, says Kimmie Ng, MD, MPH, director of Dana-Farber’s Young-Onset Colorectal Cancer … Read more
Ann-Margaret Ferrante likes a good fight. The daughter and granddaughter of Gloucester, Mass. fishermen has long devoted herself to helping those in and around her hardy hometown, first as a lawyer, and since 2009 as a member of the Massachusetts House of Representatives. For the last three years, however, Ferrante has had to balance her … Read more
A recent analysis of pancreatic cancer statistics in the United States has found that the incidence of pancreatic cancer is increasing faster in younger adults than among older adults. Though this finding is cause for further investigation, the incidence overall remains low. “This is still a rare cancer in young people,” says Asaf Maoz, MD, … Read more
Clinicians and researchers have recognized a disturbing trend in recent years: colorectal cancer (CRC) in young people is skyrocketing. In individuals under the age of 50, the incidence of CRC has increased about 2% each year since the 1990s, and, according to the American Cancer Society, is now the leading cause of death in males … Read more