New ‘Druggable’ Genetic Targets Identified in Rare Type of Bile Duct Cancer

Scientists are beginning to make inroads into treating cholangiocarcinoma, a rare, lethal cancer of the bile ducts, with precision drugs. Last year, the first targeted drug for some patients with the disease was approved. Now, Dana-Farber scientists say they have identified another genetic alteration in a small percentage of cholangiocarcinoma patients that can be attacked … Read more

Dramatic Turns, Epiphanies Mark Patient’s Journey with Colorectal Cancer

Khiem Tran’s response to drug therapy for advanced colorectal cancer seemed to defy the severity of his disease. After just a few doses of chemotherapy and a targeted drug, the cancer, which had spread from his rectum to his liver, was in full retreat, with a key marker of tumor burden dropping from stratospheric levels … Read more

What You Should Know About Appendix Cancer

Appendix cancer, or appendiceal cancer, is an incredibly rare cancer, occurring in roughly one person out of every 100,000. Despite its rarity, appendiceal tumors come in a variety of forms and presents very differently from person to person. There are treatment options for appendiceal cancer, and it usually comes with a relatively good prognosis. Here, … Read more

Despite Stage IV Cancer Diagnosis, Military Veteran Never Loses Hope

Scott Sterling spent his entire military career pushing both his mind and body to the limit. A member of the 75th Ranger Regiment, the U.S. Army’s premier large-scale special operations force and a special mission unit within the U.S. Army Special Operations Command, Sterling was trained to endure and overcome any challenge placed in front … Read more

Study Finds New Vulnerabilities in Diabetes-Associated Liver Cancer

Liver cancer that develops in people with obesity and Type 2 diabetes is dependent on elevated amounts of a protein that might be targeted for treatment by two existing drugs, say Dana-Farber scientists. The research reported in Cancer Research by Pere Puigserver, PhD, and colleagues pertains specifically to liver cancer in individuals who are obese … Read more

When Inherited Condition Leads to Two Cancers, Young Survivor Finds Hope at Prevention Center

As one of three family members with the same first and last name, John E. Duggan found individuality through initials while growing up — becoming universally known as “Jed.” Having survived both stage III colon cancer and thyroid cancer before age 30, he is refusing to let another familial tie get him down. Duggan has MUTYH-associated polyposis (or MAP), … Read more