Cancer can make its way through the body by shapeshifting through even the narrowest places, like a skilled driver navigating traffic. It has a sly way of adapting to its environment by finding detours around every blockade clinicians place in its path. A study from the lab of Nilay Sethi, MD, PhD, in Dana-Farber’s Center … Read more
Pancreatic cancer has long been difficult to detect and treat. Dana-Farber experts in the Hale Family Center for Pancreatic Cancer Research, however, are working to change that with research efforts in three key areas that are poised to advance early detection, early intervention, and treatment of the disease. They presented these topics for discussion with … Read more
Tammy Hshieh, MD, MPH, is the lead geriatrician for geriatric oncology at Dana-Farber, working with the programs for Older Adults with Hematologic Malignancy, Older Adults with Breast Cancer, and Older Adults with Gastrointestinal Cancers. As a physician-scientist, her research focuses on promoting healthier aging and improving cognition and function as well as understanding and preventing … Read more
Marsha Olsen’s grandmother always used to say, “You have one body, take good care of it.” And for most of her life, Olsen has spread that message as a middle school physical education and health teacher instilling healthy habits in her students. “I wanted all my students to have a positive experience in physical education, … Read more
When Clelia Lavoie, then 49, began experiencing abdominal pain in 2019, she had a feeling it was something serious despite dismissals from her doctor. Lavoie’s intuition was right. A colonoscopy led to a diagnosis of stage IV colorectal cancer that had metastasized to her thyroid, back, and liver. She needed surgery to remove part of … Read more
Editor’s Note: Kathy Ball-Toncic completed her 162-mile PMC ride on Aug. 2-3. “I cried many tears of joy,” she said afterwards. “A particular highlight was my oncologist Dr. Huffman coming out to cheer me on. That was a great surprise!” Nearly 1,300 cyclists will be riding in their first Pan-Mass Challenge® (PMC) this weekend, each … Read more
Cancer research often focuses on gene mutations in the parts of the human genome that produce cellular machinery called proteins. But the rest of the genome — sometimes called the “dark genome” — can also play a role. Dana-Farber researcher William Freed-Pastor, MD, PhD, a physician-scientist in the Dana-Farber Center for Gastrointestinal Oncology and Hale … Read more
Dana-Farber’s Older Adult Gastrointestinal Cancer Program specializes in treating patients who are 65 and older and have gastrointestinal cancers, such as colorectal cancer, esophageal and gastric cancer, liver cancer, neuroendocrine and pancreatic cancer. “Older adults are richly complex and multidimensional,” says gastrointestinal and geriatric oncologist Nadine McCleary, MD, MPH, who leads the program. “They deserve … Read more
In recent decades, rates of some cancers, such as colorectal cancer, have been rising in young adults under the age of 50. One possible explanation for this rise is a parallel rise in obesity rates and changes in diet, activity levels and lifestyle. However, says Kimmie Ng, MD, MPH, director of Dana-Farber’s Young-Onset Colorectal Cancer … Read more
Ann-Margaret Ferrante likes a good fight. The daughter and granddaughter of Gloucester, Mass. fishermen has long devoted herself to helping those in and around her hardy hometown, first as a lawyer, and since 2009 as a member of the Massachusetts House of Representatives. For the last three years, however, Ferrante has had to balance her … Read more
A recent analysis of pancreatic cancer statistics in the United States has found that the incidence of pancreatic cancer is increasing faster in younger adults than among older adults. Though this finding is cause for further investigation, the incidence overall remains low. “This is still a rare cancer in young people,” says Asaf Maoz, MD, … Read more
Clinicians and researchers have recognized a disturbing trend in recent years: colorectal cancer (CRC) in young people is skyrocketing. In individuals under the age of 50, the incidence of CRC has increased about 2% each year since the 1990s, and, according to the American Cancer Society, is now the leading cause of death in males … Read more
Andrew Ciardelli’s annual brothers’ hunting trip in Idaho took a turn for the worse when the stomach issues he had lived with for years suddenly became unbearable. Years before the trip, a urologist told Ciardelli that the cause of his pain and the blood in his stool was hemorrhoids. “They told me as long as … Read more
In trial after clinical trial, metastatic colorectal cancer has been largely undeterred by immune checkpoint inhibitors. Although these drugs have shown effectiveness in Hodgkin lymphoma, lung cancer, bladder cancer, kidney cancer, and nearly a dozen other malignancies, their track record against colorectal cancer has been lackluster, particularly for patients with the most common subtype of … Read more
Simone Ledward-Boseman has many roles: She’s a writer, artist, and singer. And for some time, she was a caregiver to her late husband, Chadwick Boseman, the actor known for playing Black Panther and groundbreaking figures like James Brown and Jackie Robinson. These days, Ledward-Boseman has added more titles to her list: activist and advocate. “I’m … Read more
GERD, which stands for gastroesophageal reflux disease, occurs when stomach acid repeatedly flows back up the esophagus, the tube connecting the mouth to the stomach. This irritates the lining of the esophagus, causing heartburn and, in some cases, an influx of stomach acid into the throat and mouth. Occasional GERD — also known as acid … Read more
For a while, Stephanie Dobson attributed her gastrointestinal issues to her pregnancy. It was her second, a girl born in May 2023, a baby sister to her son. But when the symptoms persisted for the 34-year-old mother, she raised the issue with her primary care provider. She was encouraged to see a gastroenterologist. On an … Read more
Dana-Farber researchers have found that a transcription factor called SOX17 gives colon cancer a safe space to develop.
Stories of young adults being diagnosed with colorectal cancer are becoming more common as the rates continue to rise among adults between 20 and 49.
Physicians have long known that there is a link between diabetes and pancreatic cancer.