FDA Approves New Treatment Option For Glioma

In an era when targeted therapies are often effective against multiple types of cancer, the U.S. Food and Drug Administration’s accelerated approval of a two-drug therapy for solid tumors carrying a specific mutation in the BRAF gene is a prime example of this trend. For patients with glioma brain cancer that harbors the mutation, the … Read more

Doctor Who Treats HIV/AIDS Shares Lessons From 40 Years Fighting Health Disparities

Valerie Stone, MD, MPH, was considering becoming an oncologist in the mid-1980s when something happened to shift her focus. People, including some very close to her, began developing a mysterious new disease. What they had was eventually identified as acquired immune deficiency syndrome, or AIDS. And as a member of two groups disproportionately impacted — … Read more

Scientists Identify Potential Target in Ewing Sarcoma Cells

Investigators led by Dana-Farber Cancer Institute’s Kimberly Stegmaier, MD, have discovered that knocking out a protein regulator in Ewing sarcoma cells causes the tumor cells to die from an overdose of a cancer-promoting protein. The regulator, a protein known as TRIM8, is critical to the survival of Ewing sarcoma cells because it controls the levels … Read more

Can Endometrial Cancer Be Treated with Immunotherapy?

Immunotherapy, which boosts the patient’s immune system response against cancer, is an emerging area of treatment and research. The immunotherapy drug pembrolizumab (Keytruda) is approved to treat women whose endometrial cancer cells have certain characteristics. What type of endometrial cancer does immunotherapy work for? Pembrolizumab is effective in shrinking or slowing the growth of a … Read more

What’s the Difference Between BRCA1 and BRCA2?

BRCA1 and BRCA2 are cancer-susceptibility genes, meaning that people who inherit pathogenic* mutations in either one have an increased risk of developing certain cancers. Hereditary (or “germline”) mutations in BRCA1 or BRCA2 cause Hereditary Breast and Ovarian Cancer Syndrome. Having a pathogenic mutation in BRCA1 or BRCA2 doesn’t mean you will definitely develop cancer, but … Read more

Immunotherapy for Pediatric Solid Tumors: What’s New?

Medically reviewed by Natalie Collins, MD, PhD New treatments that spur the immune system against cancer have entered the clinic to combat some forms of pediatric blood cancers, such as acute lymphoblastic leukemia (ALL). One form of immunotherapy, CAR T cells, has been approved for children and young adults with ALL. In treating solid tumors … Read more

Is There Evidence That GMOs Can Cause Cancer?

Medically reviewed by Stacy Kennedy, MPH, RD/LDN, CSO While there is limited scientific evidence demonstrating that eating organic food can decrease cancer risk, what is the evidence regarding its counterpart, GMOs? For now, there is insufficient evidence to conclude that consuming GMOs can increase your cancer risk. What are GMOs? GMO stands for genetically modified organism; … Read more

Which Professions are Associated with Cancer Risk?

Medically reviewed by Huma Rana, MD About 5-8% of all cancers worldwide are caused by exposures to carcinogens in the workplace, according to the National Institute of Occupational Safety and Health. Although the rate of workplace-related cancers has decreased due to safety regulations, exposure to some dusts, gases, and chemicals can increase cancer risk in … Read more

Stella’s Story: Winning Against Neuroblastoma

This post originally appeared on Discoveries, the blog of Boston Children’s Hospital. The Downey family was enjoying the holidays with family in Guatemala in 2017 when their 13-month-old daughter Stella started having unusual symptoms. “She was very clingy towards me and not acting like herself,” says Stella’s mom, Fiorella, a child life specialist at Boston … Read more

For Stem Cell Recipient, Meeting Donor Proves Fruitful Experience

As a fruit and vegetable farmer, Douglas Young measures his life’s work by the seasons. Since receiving a stem cell transplant for his rare blood cancer, he has been able to enjoy more harvests than he once thought possible — inspiring him to seek out the stranger responsible for saving his life. In spring 2019, … Read more

How to Support A Grandparent Who Has Cancer

With more people living longer than ever with chronic or serious illnesses, grandparents with cancer are a rapidly growing group. Here are some tips for how children of almost any age can support a grandmother or grandfather facing cancer. If it has been sometime since you saw your grandparent or the treatment has changed their … Read more