Drugs Targeting a Pathway in Glioblastoma Must Clear a High Bar, Study Suggests

Researchers had every reason to expect that a compound called BKM120 (also known as buparlisib) would stifle glioblastoma brain tumors lacking the protein PTEN. After all, it was known to block the tumor-promoting PI3K protein and could easily pass through the blood-brain barrier — the dense layer of cells that guards entry to the brain … Continued

Glioblastoma Patient Marks Major Milestones in Treatment and Life

OK Eason doesn’t mind jokes about his unique first name, especially lately. Healthy and thriving more than 30 months after a massive tumor was found in his brain, Eason takes pleasure in telling people that he is more than just “O.K.” Eason, 69, was diagnosed with a glioblastoma in February 2018. He had surgery immediately, … Continued

Brain Tumor Doesn’t Stop Patient from Living A Full Life

In 2018, Suzy Pope was diagnosed with an aggressive form of cancer known as glioblastoma. Typically forming in the brain or spinal cord, glioblastomas tend to have a fairly grim prognosis. But two and a half years after her diagnosis, Pope continues to thrive and make the most of every day. Her exceptional response to … Continued

What Are Common Brain Tumor Symptoms?

We asked neuro-oncologists Lakshmi Nayak, MD, and Eudocia Quant Lee, MD, MPH, from Dana-Farber Cancer Institute’s Center for Neuro-Oncology, to review the red flags that warrant a medical follow up: Headaches that are new or worsening, especially in a person who doesn’t normally have headaches. Often they are worse when lying down and in the … Continued

Glioblastoma Survivor is Thriving Seven Years After Diagnosis

Charlie Benoit was told that he had a long road ahead of him when he was diagnosed with glioblastoma in 2011. More than seven years later, he’s still doing well—and by studying patients like Benoit, researchers hope to help other patients with this incurable form of brain cancer. In 2011, Benoit, then 48, was getting … Continued

Exceptional Immunotherapy Response Triggers Search for the Cause

Six years’ worth of repeated surgeries, radiation, and chemotherapy with three different agents failed to halt the growth of Frances Zichichi’s brain tumor. As it kept recurring and more surgeries were required, Zichichi lost the use of her left side. Eventually the cancer formed masses under her scalp, causing pain, which was dulled only with … Continued

Mother and Son Support Each Other Through Each Other’s Cancer

Anne Palmer never thought she’d face a tougher challenge than aggressive breast cancer. Then, shortly after finishing treatment, she learned her 25-year-old son, Kevin, had an inoperable brain tumor. The two diagnoses, which came in 2012 and 2014, allowed mother and son – who were already close – to bond even more deeply during their … Continued

Pan-Mass Challenge Team Continues Co-Founder’s Commitment, In His Memory

Dave Mittelman died in May 2017 from brain cancer. The Pan-Mass Challenge (PMC) team he helped co-found, Team Lizard, will soon ride to honor him and the many other close friends and family members who have dealt with cancer. “At our core, we ride because we believe in a future without cancer,” says his wife, Michele Mittelman.

What’s On The Horizon For Brain Tumor Treatment?

Targeted therapies and immunotherapy are in a phase of discovery that is more promising than any preceding brain cancer research, according to the leaders of Dana-Farber’s Center for Neuro-Oncology.

Is a Headache a Sign of a Brain Tumor?

A common question about severe or persistent headaches is whether they can be caused by a serious underlying health problem, such as a brain tumor.

What Makes a Brain Tumor High-Grade or Low-Grade?

Brain tumors are graded on a scale of 1 to 4, based on how malignant, or cancerous, they are, in an effort to anticipate the tumor’s likely growth rate. A grade of 1 is the least malignant, and is considered low-grade, while 4 is the most malignant and considered high-grade.

Brain Cancer Survivor Shares Wisdom and Humor in Book

On what was supposed to be a memorable night for all the right reasons, things suddenly went terribly wrong for Marie Fricker. Arriving at Brigham and Women’s Hospital for the birth of her first grandchild, she began experiencing dueling discomforts that rooted her to a bench in the front lobby: a sensation of searing heat … Continued

What’s New in Immunotherapy for Brain Tumors?

Vaccines, drugs, and modified human cells that activate the immune system against cancer have improved outcomes and prolonged lives in some types of cancer in the past few years. For patients with glioblastoma, the most common primary brain tumor in adults, immunotherapy has shown some promise in clinical trials — but it can’t yet be … Continued

For Mother and Son, Brain Cancer Treatment Is All In The Family

Upon learning she had brain cancer in early 2016, Connie Etheridge immediately thought, “Thank goodness it’s me, and not my children.” Then, three months later, her son Trevor, 23, found out he too had brain cancer. It was a devastating double diagnosis, but the Etheridges have been by each other’s side through check-ups, radiation, and … Continued

What Is Brain Metastasis and How Is It Treated?

Medically reviewed by Nancy U. Lin, MD When cells from a breast tumor metastasize — spread through the circulation to other tissues and organs — they can migrate to the brain and form secondary tumors, termed metastases (or “mets”) there. This is especially true of the more aggressive breast cancer types. “As many as half … Continued