A Patient-Doctor Bond Forged in Fighting Follicular Lymphoma  

Throughout the 20 years Robert Jenkins has been living with follicular lymphoma, he has been through many different treatments — from traditional chemotherapy protocols to innovative approaches like CAR T-cell therapy and bispecific antibodies. His lengthy survivorship has allowed Jenkins to benefit from new advances as they’ve emerged, and along with his wife, Lorna, one … Read more

Refractory Cancer: What It Is and How It Is Treated

What does “refractory” mean medically? The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant to initial therapy or becomes resistant during treatment. “We would consider disease refractory if doesn’t respond … Read more

CAR T-Cell Therapy Helps Runner Zoom Past Follicular Lymphoma

Ken Karnes enjoys his whirlwind of a life. If he’s not traveling to Europe or Asia for his high-tech job — pandemics permitting — he and his wife Mary are busy keeping up with their four daughters, two sons-in-law, and three grandchildren. Road races are also on the 60-year-old’s agenda, with an eye toward his … Read more

What is ‘Chimeric’ Antigen Receptor (CAR) T-Cell Therapy

One of the most exciting new cancer treatments, CAR T-cell therapy takes its complicated name, in part, from a fire-breathing monster in an ancient Greek myth.  CAR is an acronym for “chimeric antigen receptor,” referring to genetically engineered molecules manufactured in a laboratory, inserted into the genetic material of immune T cells that have been removed from … Read more

Giving Thanks: Stem Cell Transplant Recipient Visits Donor’s Home in Germany

Charles “Chuck” Vanada has been looking forward to Thanksgiving with his family this year, but the non-Hodgkin lymphoma survivor has already experienced feelings of gratitude in 2017 more powerful – and in places more unexpected – than anything he could have imagined. In April, Vanada and his wife, Debbie, traveled from their Boston-area home to … Read more

FDA Approves CAR T-Cell Therapy for Non-Hodgkin Lymphoma

A drug called Axicabtagene ciloleucel (KTE-C19) has become the first chimeric antigen receptor (CAR) T-cell therapy approved to treat a form of cancer in adults, the Food and Drug Administration (FDA) announced today. The decision means the drug, known as Yescarta, can now be used for some adults with refractory aggressive non-Hodgkin lymphoma (NHL). The FDA ruling in … Read more

Non-Hodgkin Lymphoma Symptoms and Signs

Non-Hodgkin lymphoma (NHL) refers to cancer of lymphocytes, which are type of white blood cell and part of the immune system. NHL can occur at any age and is often marked by symptoms including enlarged lymph nodes, fever, and weight loss. It is one of the most common cancers in the United States, accounting for about … Read more

What Are The Side Effects of CAR T-Cell Therapy?

CAR T-cell therapy is a form of immunotherapy in which patients’ T cells are modified to become better at tracking down and destroying tumor cells. CAR T cells are made by extracting thousands of a patient’s T cells, sending them to a lab where they’re outfitted with genes and proteins that improve their cancer-fighting prowess, and … Read more

Pregnant with Non-Hodgkin Lymphoma, This Mom Found Care and Comfort at Dana-Farber

Elizabeth Larcom has six children, but it’s the youngest that she calls her “miracle baby” – and with good reason. In August 1997, the Army moved the Larcom family to Alaska with five kids under 12 and mom Elizabeth pregnant with the sixth. Soon after, husband and dad, Chuck, left for Army training in Louisiana. … Read more

New Immunotherapy Therapy Approved for Lymphoma Patients

The Food and Drug Administration (FDA) approved a new kind of immunotherapy drug for adults and children with classical Hodgkin lymphoma who have relapsed after three or more prior lines of therapy. The approved drug, pembrolizumab (Keytruda), is part of a class of immunotherapy drugs called checkpoint inhibitors that block the PD-1 protein, which is … Read more

Lymphoma Patient Gets Back on the Court Post-Treatment

For much of his 17 years, Spencer Riley has lived to play basketball. This winter, his favorite sport helped the teenager get back to life. Riley was diagnosed with non-Hodgkin lymphoma in 2016 and treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center that summer. He underwent an intensive three-month treatment cycle: one week of … Read more

Non-Hodgkin Lymphoma and Hodgkin Lymphoma: What’s the Difference?

Hodgkin and non-Hodgkin lymphoma are the two main types of lymphoma, a cancer that affects the lymphatic system. The lymphatic system produces and transports white blood cells to fight infection. While they have many characteristics in common, there are some significant differences between Hodgkin and non-Hodgkin lymphoma, including the age groups they affect, how they … Read more