While hematological cancers like leukemia, lymphoma, and multiple myeloma involve white blood cells, other, rarer hematologic malignancies affect red blood cells and platelets. These include polycythemia vera, in which the bone marrow produces too many red blood cells, and essential thrombocythemia, in which platelets levels are abnormally high. Both are chronic diseases that can usually … Read more
Patricia Smith’s experience with cancer will stay with her for the rest of her life. “Walking through deep waters changes you,” she says. “You’re still the same person, but you’re different.” In 2009, Smith was diagnosed with B-cell diffuse lymphoma after she experienced weeks of fatigue and found a lump under her right arm. She … Read more
Follicular lymphoma is a slow-growing form of non-Hodgkin lymphoma (NHL) that arises in white blood cells called B lymphocytes. It’s named for the clumps of abnormal B cells, called follicles, that develop in patients’ lymph nodes. It accounts for 20-30% of all cases of NHL. Although follicular lymphoma currently isn’t curable, patients can live with … Read more
Bispecific antibody therapies are a type of immunotherapy for patients with B-cell non-Hodgkin lymphoma. These therapies provide a valuable new option for patients. There are many standard therapies that are monoclonal antibodies. These therapies treat cancer by binding to a marker on cancer cells and rallying the immune system to destroy them. Bispecific antibodies are … Read more
BCL2 inhibitors are drugs that prompt cancer cells to die by altering the interactions among key proteins within the cells. They were clinically developed, in large part, by researchers at Dana-Farber and have been approved by the U.S. Food and Drug Administration (FDA) for the treatment of acute myeloid leukemia (AML) and chronic lymphocytic leukemia … Read more
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, diagnosed in more than 18,000 people in the U.S. every year. It is a fast-growing lymphoma that can arise in the lymph nodes or, more rarely, in organs such as the spleen, liver, and others. As its name indicates, DLBCL involves the … Read more
Throughout the 20 years Robert Jenkins has been living with follicular lymphoma, he has been through many different treatments — from traditional chemotherapy protocols to innovative approaches like CAR T-cell therapy and bispecific antibodies. His lengthy survivorship has allowed Jenkins to benefit from new advances as they’ve emerged, and along with his wife, Lorna, one … Read more
When Youling Sun was diagnosed in Shanghai, China, with acute myeloid leukemia (AML) in 2018, he called his son, Conghao, in Boston, for advice. His son’s message was unequivocal: Come to Boston for your treatment. Today, Sun, a retired office worker from Shanghai, has multiple reasons to be thankful he took that advice — both … Read more
A pair of subversives, the genes BTK and PLCG2 are often mutated in chronic lymphocytic leukemia (CLL) that is resistant to the drug ibrutinib. But how common are these genetic alterations and to what extent do they contribute to ibrutinib resistance? The answers will help doctors determine which targeted therapies are most likely to help … Read more
As a systems operator who works to help maintain the electrical grid for New York state, Brian Houlihan, 46, is used to getting power to the people. But when the multiple myeloma he has lived with since 2011 stopped responding to chemotherapy, it was Houlihan who needed a recharge. He got it, through an innovative … Read more
Waldenström macroglobulinemia, a rare form of non-Hodgkin lymphoma, has its share of eccentricities. One of the hallmarks of the disease, for example, is an overabundance of a particular protein, yet other conditions may also have that feature. It’s also not unusual for patients to have very high protein levels but have no symptoms or mild … Read more
David Trueblood’s long career in journalism was shaped by new technology, including the rise of digital photography and the impact of online media. So, upon learning in early 2023 that he would need a stem cell transplant due to myelodysplastic syndrome (MDS), a rare blood disorder impacting his bone marrow, Trueblood appreciated the role innovation … Read more
Michelle Karalekas’ time in the Mont Tremblant Ironman Triathlon in Quebec on Aug. 20 — 14 hours, 5 minutes — was not her fastest in the grueling event, but it may have been her most impressive. It was the first time she’d competed since undergoing a stem cell transplant for acute myeloid leukemia (AML) almost … Read more
In 2022, the drug teclistamab became the first bispecific antibody to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of multiple myeloma. Experts say the drug represents one of the most important advances in recent years against myeloma, a blood cancer diagnosed in more than 35,000 people in the United … Read more
In most ways, Bill Ross’s stem cell transplant for multiple myeloma at Dana-Farber Brigham Cancer Center (DFBCC) wasn’t out of the ordinary. He received chemotherapy to destroy the tumor cells in his body and then an infusion of his own hematopoietic stem cells, which flocked to his bone marrow and regenerated his blood supply. Over … Read more
Bone marrow is the soft, spongy material inside our bones. Occupying one of the most protected places in the body, it produces nearly all the components of blood. These include red blood cells, which deliver oxygen throughout the body, white blood cells, which help fight disease, and platelets needed for clotting. The marrow generates approximately … Read more
Hodgkin lymphoma (sometimes called Hodgkin’s lymphoma) is a form of cancer that affects the immune system. It starts in the white blood cells, but what patients and doctors will most likely notice first is a lump in the neck, under the arm, or in the groin. How is Hodgkin lymphoma staged? Hodgkin lymphoma is staged … Read more
Tom Lomaglio, Jr., learned he had a rare blood cancer called Waldenström’s Macroglobulinemia (WM) in 2000. His father, Tom, Sr., had been diagnosed in 2004, and then his sister, Diane, in 2007. They were all referred to Dana-Farber for care. When Lomaglio visited the first time, he met Steven Treon, MD, PhD, director of the … Read more
A novel hematopoietic stem cell transplantation (HSCT) method utilizing ‘graft sculpting’ is being tested in a phase 1 clinical trial in patients with refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who are at the highest risk of relapse after ‘standard’ transplants. In fact, the patients in the trial don’t qualify for a standard … Read more
Waldenström’s macroglobulinemia (WM) is a blood cancer that is extremely rare, affecting around 1500 people in the US each year. About 20 percent of those cases are considered familial, meaning that many members of the same family also have some form of blood cancer, such as myeloma or lymphoma. An even smaller group — five … Read more