What is Mantle Cell Lymphoma and How Is It Treated?

Medically reviewed by Ann S. LaCasce, MD, MMSc Mantle cell lymphoma is a rare, often aggressive form of non-Hodgkin lymphoma (NHL), a cancer that involves white blood cells known as lymphocytes, which help protect the body from disease. It is named for its origins in the mantle zone — a ring of cells within the … Continued

Multiple Myeloma Fails to Keep Football Player-Turned-Broadcaster Out of Action

Many sports stars have helped support research and care at Dana-Farber by appearing on the WEEI/NESN Jimmy Fund Radio-Telethon presented by Arbella Insurance Foundation, but few have done so quite like pro football wide receiver-turned-broadcaster Jimmy Cefalo. When Cefalo was interviewed on-air during the August 2019 event at Fenway Park, he used the opportunity to share some … Continued

What Are the Differences Between Lymphocytic and Myelogenous Leukemia?

Medically reviewed by Martha Wadleigh, MD Leukemia arises from malfunctions in stem cells within the bone marrow that cause abnormal white blood cells to flood into the bloodstream. Leukemias are classified as either myelogenous (also called myeloid) or lymphocytic, depending on which types of white blood cells are affected. What is the difference between these types … Continued

Adult Leukemia: What You Need to Know

Medically reviewed by Richard M. Stone, MD More than 60,000 new cases of adult leukemia are diagnosed in the U.S. each year. Although it is one of the more common childhood cancers, leukemia occurs more often in older adults. How does leukemia develop in adults? Leukemia is a cancer of the body’s blood-forming tissues that results in large … Continued

What Are the Most Common Blood Cancers in Adults?

Medically reviewed by Ann S. LaCasce, MD, MMSc Non-Hodgkin lymphoma Non-Hodgkin lymphoma (NHL) is a type of cancer that forms in the lymph system, part of the body’s immune system. There are many kinds of NHL that develop from various types of white blood cells, including B cells, T cells, and NK cells. The majority … Continued

New Drug Benefits Patients With Myeloma Who Are Resistant to All Therapies

Earlier this year, a novel drug became the first agent to receive U.S. Food and Drug Administration (FDA) approval for patients with multiple myeloma who have exhausted all types of currently available therapies, including proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. A clinical trial found that 26.2 percent of such patients responded with significant shrinkage … Continued

Basic Research Spurs New Wave of Clinical Trials of Therapies for T-Cell Lymphoma

Medically reviewed by David M. Weinstock, MD, and Eric Jacobsen, MD By banding together to study the basic biology and vulnerabilities of T-cell lymphoma, scientists at several major cancer research centers have sparked a surge of clinical trials of promising treatments for the disease. The string of new trials, some already open, some expected to … Continued

Resistance to Targeted Leukemia Drug Lurks in Cells’ “Powerhouse”

Medically reviewed by Catherine J. Wu, MD Within every human cell, a fateful balance prevails. The mitochondria — where nutrients from food are converted into fuel for the cell — serve as a kind of jury box where pro-survival proteins contend with proteins that favor cell death. In the ebb and flow of these proteins, … Continued

New Options for First-Line Treatment of Chronic Lymphocytic Leukemia

Medically reviewed by Jennifer Brown, MD Most patients with chronic lymphocytic leukemia (CLL) now have several options for first-line therapy, thanks to new clinical trial results and novel targeted agents. Many patients with CLL, a slowly progressive blood cancer in which the bone marrow makes too many white blood cells, don’t need immediate treatment but … Continued

What Are Myelodysplastic Syndromes and How Are They Treated?

Medically reviewed by David P. Steensma, MD Myelodysplastic syndromes (MDS) are a group of diseases of the blood and marrow that result in the body being unable to produce enough healthy, mature blood cells. MDS develops when the blood stem cells found in the bone marrow become injured (i.e., they acquire a mutation in the … Continued

What Are Precursor Blood Conditions and How Are They Treated? [Updated 2019]

Precursor conditions are early phases of blood diseases that may develop into cancers such as lymphoma, leukemia, Waldenström’s macroglobulinemia, and multiple myeloma. Most people do not experience symptoms, and since doctors rarely screen for precursor conditions, they are often diagnosed after routine blood tests. “Many diagnoses are purely incidental,” says Irene Ghobrial, MD, co-principal investigator … Continued

Grandfather Gets Back to Life and Nature after CAR T-Cell Therapy for Lymphoma

Jerry Jalbert is always up for new adventures. He did not expect that non-Hodgkin lymphoma (NHL) would be one of them, but with the help of CAR T-cell therapy that keeps his cancer at bay, the 73-year-old professional photographer-turned-baker-turned-forest checkpoint operator is continuing to enjoy life’s many journeys alongside his wife, Ethel. “We are not … Continued

For Father with Non-Hodgkin Lymphoma, CAR T-Cell Therapy Saves Memories and More

In May 2018, Tyler Goodwin underwent CAR T-cell therapy for follicular non-Hodgkin lymphoma (NHL). While he was having preparatory chemotherapy for the procedure, a surprise visitor to his hospital bedside provided a powerful reminder of why this promising new cancer treatment was so important to him. “It was my daughter Theresa, all made up for … Continued

New Study Reports “Curative Potential” of a Combination Therapy for Some Leukemia Patients

Medically reviewed by Matthew Davids, MD, MMSc Chemoimmunotherapy combined with a targeted drug given for two years has achieved undetectable minimal residual disease (MRD) for a high proportion of younger patients with chronic lymphocytic leukemia (CLL), Dana-Farber scientists report. The phase 2 clinical trial results are so favorable that they represent a step toward “a … Continued

Study Finds Advantage for African Americans with Multiple Myeloma

In a surprising rebuttal of previous findings, a new study shows that African Americans with multiple myeloma have an overall higher survival rate than Caucasians with the disease when all patients have equal access to cutting-edge therapies. The results raise questions about the biology of this type of cancer. Multiple myeloma, a cancer that arises … Continued

Hodgkin Lymphoma: The Latest in Treatment and Research

Medically reviewed by Philippe Armand, MD, PhD, and Margaret A. Shipp, MD Hodgkin lymphoma (HL) is a cancer that begins in white blood cells called lymphocytes, which play a significant role in the body’s immune system against disease. There have been major advances in the treatment of the disease in the past several years. A … Continued

Standing up Against Multiple Myeloma Starts with a PROMISE

In 2011, Diane Dike, PhD, lost her mother to complications from multiple myeloma — a cancer of the bone marrow involving plasma cells. The pair were always close, and even share the same birthday: October 23. The illness and death of her mother was extremely difficult for the whole family, Dike says. One of the most … Continued