Study Reveals Promising Combination Therapy for T-Cell Prolymphocytic Leukemia

Cancer cells have a bias toward survival, often becoming heavily reliant on certain protein pathways to sustain themselves. Scientists are finding ways to turn that survival instinct into a liability — by making the cells even more dependent on those pathways, then choking the pathways off. It’s an approach that has now yielded a promising … Continued

Rizwan Romee, MD: A Researcher Fascinated with the Immune System

Rizwan Romee, MD, is a medical oncologist at Dana-Farber and treats patients with advanced blood cancers such as leukemia and myelodysplastic syndrome. He is also the director of the Haploidentical Stem Cell Transplantation Program at Dana-Farber and principal investigator of the Romee Lab for NK Cell Gene Manipulation and Therapy. Why did you decide to … Continued

Young Father Gets the Cancer Treatment He Needs During COVID-19

Chris Devin never expected to be diagnosed with multiple myeloma at the age of 45 — and being told he had cancer during the COVID-19 pandemic was far from ideal.  But Devin quickly learned that he could rely on his team at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) for the best treatment options. While COVID-19 … Continued

What is Richter’s Syndrome and How is it Treated?

Richter’s syndrome involves the rapid transformation of chronic lymphocytic leukemia (CLL) into a significantly more aggressive form of lymphoma, usually diffuse large B-cell lymphoma (DLBCL), but occasionally Hodgkin lymphoma (HL). It arises in 2-10% of all patients with CLL and can occur at any time in the course of the disease. The goal of treatment … Continued

CAR T-Cell Therapy Helps Runner Zoom Past Follicular Lymphoma

Ken Karnes enjoys his whirlwind of a life. If he’s not traveling to Europe or Asia for his high-tech job — pandemics permitting — he and his wife Mary are busy keeping up with their four daughters, two sons-in-law, and three grandchildren. Road races are also on the 60-year-old’s agenda, with an eye toward his … Continued

What are Indolent Lymphomas and How Are They Treated?

Indolent lymphomas are types of non-Hodgkin lymphoma (NHL) that grow and spread slowly. They account for about 40% of all NHL cases in the United States and generally arise later in life. Treatment for indolent lymphomas depends on a variety of factors, including the type and stage of the disease (how far it has advanced). … Continued

Signs and Symptoms of Blood Cancers

Blood cancers (or hematologic cancers) are diseases that originate in blood-forming tissue such as the bone marrow or cells within in the immune system. There are three main types of blood cancers: Leukemia: cancer that originates in the body’s blood-forming tissues, such as the bone marrow. The disease causes large numbers of myeloid blood cells … Continued

Acute Leukemia Diagnosis: What to Know and Expect

Treatment for acute forms of adult leukemia has advanced markedly since the days when all patients generally received the same course of treatment. A patient’s age and overall health, the type of leukemia he or she has, and the goal of therapy all influence the treatment plan. What are the types of acute leukemia? There … Continued

CAR T-Cell Therapy Offers Lymphoma Patient Renewed Hope

Tiffany “Tiff” Trant couldn’t help but smile. All three of her children were home, and the family was deciding on dinner and a group activity. They thought about working on a puzzle, sitting down for their reoccurring poker game, or just spending the night talking. These simple pleasures have gained new meaning ever since Trant … Continued

BPDCN: What’s the Latest in Treatment and Research?

What is BPDCN? Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive blood cancer that can affect the skin, blood, and bone marrow. It has characteristics similar to leukemias and lymphomas, but almost always first appears as lesions in the skin. What are the treatment options for BPDCN? The first drug that was … Continued

Venetoclax Combination Approved for Older Patients with AML

The U.S. Food and Drug Administration (FDA) approved a novel targeted drug to treat acute myelogenous leukemia (AML) in older patients, a segment of the blood cancer population in dire need of improved therapies. In a phase 3 clinical trial, researchers showed that the oral drug, venetoclax (or Venclexta), when given along with azacitidine, could … Continued

Patient Living Life Despite Leukemia and COVID-19

Tim O’Neill likes to keep moving — whether on his boat, his motorcycle, in his running shoes, or while steering an RV across 47 states. Chronic lymphocytic leukemia (CLL) has failed to stop him from these pursuits, and he’s determined not to let a pandemic do so either. “I’m more careful these days because of … Continued

New Drug Regimens Show Promise in Early and Late Myeloma

Treatment advances for multiple myeloma continue to bring improved outcomes for patients in different stages of their disease. Recent clinical trial reports show progress in treating two myeloma populations — newly diagnosed, transplant eligible patients, and individuals whose disease has progressed following several lines of therapy. In one trial, the phase 2 GRIFFIN study showed … Continued

Wave of New Therapies Improve Outcomes for Patients with Multiple Myeloma

For many patients with multiple myeloma, a new generation of drugs and drug combinations is producing better outcomes and fewer side effects. In recent months, several novel therapies studied and tested by Dana-Farber scientists have gained approval from the U.S. Food and Drug Administration (FDA) or taken a step toward approval after posting solid results … Continued

Cancer Patient Faces Multiple Diagnoses with the Strength of a Warrior

One bout of cancer is enough to contend with, but since 2014 Mary Johnson has had to cope with four different cancers and related conditions. Despite these tests of her physical and emotional strength, Johnson is doing well today after treatment at Dana-Farber. “Coming to Dana-Farber gave me confidence because they supported me, and I … Continued

‘Watchful Waiting’ for Lymphoma: What You Need to Know

If you’ve been diagnosed with slow-growing lymphoma but don’t have any symptoms of the disease, your doctor is likely to recommend monitoring the disease closely but not treating it until symptoms appear — an approach known as watchful waiting. This advice might seem to run counter to the standard recommendation that cancer be treated at … Continued