Hodgkin Lymphoma: The Latest in Treatment and Research

Medically reviewed by Philippe Armand, MD, PhD, and Margaret A. Shipp, MD Hodgkin lymphoma (HL) is a cancer that begins in white blood cells called lymphocytes, which play a significant role in the body’s immune system against disease. There have been major advances in the treatment of in the past several years. A two-in-one drug … Continued

Standing up Against Multiple Myeloma Starts with a PROMISE

In 2011, Diane Dike, PhD, lost her mother to complications from multiple myeloma — a cancer of the bone marrow involving plasma cells. The pair were always close, and even share the same birthday: October 23. The illness and death of her mother was extremely difficult for the whole family, Dike says. One of the most … Continued

Hodgkin Lymphoma Patient Aims to Lessen Cancer Stigma

Chloe Svolos is a social butterfly. When she isn’t working in the fundraising office for Dana-Farber’s Jimmy Fund, the 26-year-old is spending time with family, going out with friends, hanging out with her boyfriend, Luke, or traveling. She also recently completed treatment for lymphoma — so she’s still adjusting to her “new normal.” But in … Continued

For Stem Cell Recipient, Meeting Donor Proves Fruitful Experience

As a fruit and vegetable farmer, Douglas Young measures his life’s work by the seasons. Since receiving a stem cell transplant for his rare blood cancer, he has been able to enjoy more harvests than he once thought possible — inspiring him to seek out the stranger responsible for saving his life. In spring 2019, … Continued

What is the Difference Between B-cell Lymphoma and T-cell Lymphoma?

Medically reviewed by Eric Jacobsen, MD Lymphoma comes from a type of immune cell called a lymphocyte, which is important in helping your body fight infection. The two main types of lymphocytes are B lymphocytes (B-cell) and T lymphocytes (T-cell), and each has a slightly different function in the immune system. Each can also give … Continued

What Does a Lymphoma Lump Feel Like?

Medically reviewed by Eric Jacobsen, MD One symptom of lymphoma can be the development of lumps under the skin, usually in the neck, armpit, or groin. The lumps have a rubbery feel and are usually painless. Not all such lumps are a sign of lymphoma, but when they occur at these sites, it’s advisable to … Continued

What is the Difference Between Gene Therapy and Immunotherapy?

Gene therapy and immunotherapy are both types of treatment for cancer and other diseases, and they have some points at which they intersect. But ultimately they represent different approaches to disease therapy. Most diseases aren’t caused by a single mutant gene — an alteration in the DNA sequence — but some mainly rare, inherited disorders, … Continued

New therapies spark leap in treatment of AML in adults

In just over a year, the treatment of acute myelogenous leukemia (AML) in adult patients has undergone something of a revolution. Since mid-2017, the U.S. Food and Drug Administration has approved nine new targeted therapies for the disease, in contrast to none during the previous 12 years. The approvals amount to a “game-changer for how … Continued

How are bispecific antibodies being used to treat blood cancers?

Many of the immunotherapy drugs that are transforming the treatment of certain types of cancer are based on antibodies — artificial proteins that latch onto a molecular target, called an antigen. Bispecific antibodies, which can bind to two antigens at the same time, are being tested and moving toward clinical use in some blood cancers. … Continued

Study Uncovers Dual Gene-Control System in Multiple Myeloma

The process of converting genetic information from DNA to RNA, known as transcription, is a joint undertaking. Sections of DNA, known as promoters, collaborate with other sections known as enhancers to recast the genetic code into a form that can be used by cells to make proteins. As with many partnerships, however, it hasn’t been … Continued

5 Tips for Reducing Scanxiety

Irritability, sweaty palms, increased heart rate, and nausea are common symptoms many patients experience when preparing for an upcoming exam. This feeling of apprehension and discomfort is called scanxiety, which aptly refers to the anxiety or worry patients often feel before undergoing a scan or receiving the results of an examination. “Anxiety often comes when … Continued

Researchers Making Headway on Treatment for Rare Blood Cancer

It began with some skin spots on his back and a lump on his knee that he thought was just a bruise from a golfing injury. After a series of exams and a biopsy, David Tracy, 74, of Waterford, Conn., finally learned he had a very rare and puzzling blood cancer that didn’t even have … Continued

Multiple Myeloma Patient Committed to Persevering

Russ Horn went to work every day as a firefighter for almost 30 years. But now he has a new job—one that takes the same courage, hard work, and perseverance required in his last role. In 2014, Horn, then 50, was diagnosed with multiple myeloma—a cancer of plasma cells—after a minor slip at work sent … Continued

Myeloma Study Makes the Case for a New Standard for Predicting Long-Term Outcome

As new treatments for multiple myeloma have extended patient survival—from an average of three years to more than 10 in some cases—physicians and researchers face a new challenge: how to predict a drug’s long-term effectiveness? How to tell, early on, whether one drug is likely to extend patients’ lives more than another? At Dana-Farber’s Jerome Lipper … Continued

Research Update: Scientists Present Novel Ways of Treating Blood Cancers and Diseases

Dana-Farber scientists presented an abundance of new research at the 60th American Society of Hematology (ASH) Annual Meeting and Exposition, held December 1-4 in San Diego. Their research spanned the gamut of hematological diseases, including leukemia, lymphoma, multiple myeloma, and myelodysplastic syndrome—as well as treatment modalities, such as stem cell transplantation and CAR T-cell therapy. A … Continued

For Lymphoma Patient, Research Leads to Stem Cell Transplant

A troublesome cough led Patty Reid on a nine-months-long medical odyssey that resulted in a diagnosis of non-Hodgkin lymphoma (NHL). Just as the then-60-year-old was preparing for a stem cell transplant in late 2016, a new research discovery prompted her doctors to change the type of transplant Reid received—greatly lessening her risk for another cancer … Continued

After Two Cancer Diagnoses, Cancer Survivor Finds A Light at the End of the Tunnel

There was a time when Georgette Hannoush couldn’t imagine a bright future. In a four-year span, the mother of four—including triplets—was diagnosed with two different types of cancer. But because of her team at Dana-Farber Cancer Institute, Hannoush has been in remission for more than three years—and she credits her faith and the people she … Continued

From Patient to Employee: A Return to Dana-Farber

No athlete welcomes an injury, but a simple scratch may have saved Rich Oakley’s life. Oakley was diagnosed with cancer in 2003, as a high school senior, after a scratch from a sports injury led to a swollen neck. When the swelling didn’t subside, Oakley’s mother brought him to the doctor for tests, which revealed … Continued

For Grandmother, Rare Lymphoma Proves a Short Detour in an Active Life

Sandi and George Schussel first met on an airplane, beginning a 55-year journey that has taken them across the world, over oceans, into the mountains, and down countless paths. When Sandi learned she had a rare blood cancer known as angioimmunoblastic T-cell lymphoma (AITL), the couple saw her diagnosis as another trail to travel. This … Continued