Pediatric Leukemia Survivor Having a Ball After CAR T-Cell Therapy

After undergoing a promising new treatment for acute lymphoblastic leukemia (ALL), Cole Malone is back to doing what he loves: playing on a flag football team with his twin brother, Michael. Cole and Michael Malone, who are 14, already know plenty about teamwork. Michael served as a perfect-match donor when Cole underwent a stem cell … Continued

CAR T-Cell Clinical Trial Has Multiple Myeloma Patient Back On Her Feet

A year ago, Kelly Lamphere’s multiple myeloma was not responding to treatment, and her legs were so weakened by the cancer in her bones that she relied on a wheelchair and a walker. Today, because of CAR T-cell therapy, Lamphere’s disease is under control—and she can walk unaided again.

What’s Next in CAR T-Cell Therapy?

CAR T-cell therapy—a form of immunotherapy that uses genetically engineered T cells to intensify the immune system’s response to cancer—represents one of the biggest advances against cancer in recent years.

How Treatment Works for CAR T-Cell Therapy Patients

CAR T-cell therapy is a form of immunotherapy that uses specially modified T cells – part of the body’s defense system against disease – to attack cancer. This therapy has proven strikingly successful for some patients with certain forms of blood cancer. As of May 2018, CAR T-cell therapy has been approved by the U.S. Food and … Continued

What is a Living Drug?

“Living” drugs consist of fully functional cells that have been selected and often modified to treat specific diseases, such as cancer. CAR T-cell therapy and therapeutic vaccines fall into this category.

What is Refractory Cancer and How Is It Treated?

The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes resistant during treatment. “We would consider disease refractory if doesn’t respond at all or … Continued

How Gene Therapy Works in Treating Cancer and Other Conditions

There are many types of gene therapy, but all of them involve adding to or modifying the genetic program in a person – his or her DNA blueprint that provides instructions for building and operating the body. Gene therapy technology has been developed over several decades and has been successfully used to correct rare blood … Continued

CAR T-Cell Therapy: Is It Right For You?

CAR T-cell therapy is a cancer treatment in which a patient’s immune system T cells are genetically modified to mount a more effective attack on cancer. As of May 2018, CAR T-cell therapy has been approved by the U.S. Food and Drug Administration as standard therapy for some adult patients with aggressive non-Hodgkin lymphoma that has relapsed after … Continued

Cancer Treatment: A Look at How It Has Evolved in 70 Years

In 1947, when Dana-Farber Cancer Institute founder Sidney Farber, MD, set out to find a drug treatment for childhood leukemia, cancer treatment took two forms – surgery to cut out cancerous masses, and radiation therapy to burn them out. Cancers that couldn’t be removed or irradiated – either because of their position in the body, because … Continued

CAR T-Cell Therapy for Lymphoma: What You Need to Know

CAR T-cell therapy, like all forms of cancer immunotherapy, seeks to sharpen and strengthen the immune system’s inherent cancer-fighting powers. It involves treating patients with modified versions of their own immune system T cells ­– white blood cells that help protect the body from disease. The groundbreaking therapy recently became the first of its kind … Continued

FDA Approves CAR T-Cell Therapy for Non-Hodgkin Lymphoma

A drug called Axicabtagene ciloleucel (KTE-C19) has become the first chimeric antigen receptor (CAR) T-cell therapy approved to treat a form of cancer in adults, the Food and Drug Administration (FDA) announced today. The decision means the drug, known as Yescarta, can now be used for some adults with refractory aggressive non-Hodgkin lymphoma (NHL). The FDA ruling in … Continued

Non-Hodgkin Lymphoma: What’s New in Treatment? [Webchat]

Non-Hodgkin lymphoma is one of the two major subtypes of lymphoma, and about 72,000 people will be diagnosed with this cancer by the end of 2017, according to the American Cancer Society. There are more than 50 types of non-Hodgkin lymphoma – including B-cell and T-cell lymphomas, as well as fast-growing and slow-growing lymphomas. There … Continued

CAR T-Cell Therapy Gives Cancer Patients New Hope

Judy Wilkins tried four different chemotherapy regiments over 18 grueling months to try to put her lymphoma into remission. Her team never could. But thanks to CAR T-cell therapy, an emerging immunotherapy treatment that is showing great promise in clinical trials nationwide, Wilkins is cancer-free. CAR (Chimeric Antigen Receptor) T-cell therapy is a form of cellular … Continued

Stem Cell Transplants and Cellular Therapies: What’s the Difference?

Donor stem cell transplants and other cellular therapies are treatment approaches that harness the immune system to fight cancer using cells from the patient or from healthy donors. Stem cell transplants are used to treat blood-related cancers such as leukemia, lymphoma, and multiple myeloma, as well as certain non-cancerous blood disorders. Patients first receive chemotherapy … Continued

FDA Gives First-Ever Approval to CAR T-Cell Therapy

The Food and Drug Administration (FDA) announced today that a drug called CTL019 has become the first chimeric antigen receptor (CAR) T-cell therapy approved to treat a form of cancer. The decision means the drug can be used as standard therapy for the treatment of pediatric and young adult patients with B-cell acute lymphoblastic leukemia (ALL) … Continued

What Are The Side Effects of CAR T-Cell Therapy?

CAR T-cell therapy is a form of immunotherapy in which patients’ T cells are modified to become better at tracking down and destroying tumor cells. CAR T cells are made by extracting thousands of a patient’s T cells, sending them to a lab where they’re outfitted with genes and proteins that improve their cancer-fighting prowess, … Continued