One by one, our immune cells march to the frontlines when it gets a whiff of an invader. They are ready to fight and protect our systems from what is about to attack. But what if we can recruit these specialized soldiers for glioblastoma — a malignant brain cancer that struggles to have enough immune … Read more
CAR T-cell therapy is a newer form of immunotherapy that can treat some types of blood cancers, such as lymphoma, multiple myeloma, and leukemia. Patients can be treated with this therapy as an inpatient or outpatient, depending on their case and specific needs. “Historically, we were giving these therapies in the hospital, but what we’ve … Read more
Rare genetic cancers may affect few people, but their complexity makes them powerful windows into how even the most common cancers develop and behave. Delving into understanding how DNA is damaged and repaired in rare genetic conditions is how physician-scientist Alan D’Andrea, MD, built a foundation of knowledge about Fanconi anemia (FA) – a rare genetic disease of the bone marrow that significantly increases the risk of certain cancers. In people with … Read more
Cancer treatment has evolved dramatically in the first quarter of this century, but there is still much more to do to improve the lives of people with cancer. At Dana-Farber, research continues in the clinic and in the lab in efforts to continue to bring advancements in treatment and prevention for patients. That research has resulted in exciting … Read more
There are over 100 precision medicines approved for the treatment of cancer. These therapies work to shut down the cancer-driving effects of specific mutations. Matching a patient to a medicine — the practice of precision oncology — is complex and advancing rapidly. However, there is no easy, standardized way for oncologists to stay informed of advances. “The clinicians we engaged with said that catching up with FDA approvals is far … Read more
As we close out the first quarter of the twenty-first century, it isn’t hard to notice how much the world has changed since the year 2000. Smartphones. Social media. Artificial intelligence. But how much has cancer care changed? A lot. Possibly more than you think. Treatment for many cancers now include many options beyond chemotherapy, … Read more
In 2014, Dana-Farber pediatric oncologist Brian Crompton, MD, discovered that a gene called STAG2 is mutated in about 15 percent of patients with Ewing sarcoma, a form of bone cancer that largely occurs in children and adolescents. Now, that molecular insight could hold the keys to advancing treatment for the disease. New research led by senior authors Crompton and pediatric oncologist Katherine Janeway, MD, Dana-Farber Pediatric Oncology Section Chief and Chair of the Children’s … Read more
Big ideas are all around us. They pop into our heads when we least expect it and consume our minds until we take steps to make them happen. That’s how research begins, continues, and evolves. At Dana-Farber, scientists are attacking cancer at every level. Researchers go through a continuous cycle of experimentation to see the … Read more
What makes us humans lies in our genes. But even with all their power, they are remarkably vulnerable to errors. But these potentially harmful errors are an opportunity for humankind to study and treat, as it has been for Dana-Farber’s physician-scientist Srinivas Viswanathan, MD, PhD. “We have the ability to make an impact,” Viswanathan said. “There are so many unanswered questions in cancer biology still, especially in our understanding of rarer subtypes of kidney cancer.” One of these subtypes — called translocation renal cell carcinoma (tRCC) — occurs when a gene quietly moves, fuses with another gene, and … Read more
Every year, physician researchers at Dana-Farber Cancer Institute reveal new treatments, protocols, and outcomes that advance cancer research. At one of this year’s biggest cancer research conferences, the European Society for Medical Oncology (ESMO) Congress in Berlin, Germany, Dana-Farber researchers presented 22 studies in breast, lung, and bladder cancer. Here are three of the most exciting advancements — several nearing U.S. Food and Drug Administration (FDA) approval — shared by our experts nearly 4,000 miles across the world. An oral therapy for advanced breast cancer Erica Mayer, MD, MPH, director … Read more
Cancer can make its way through the body by shapeshifting through even the narrowest places, like a skilled driver navigating traffic. It has a sly way of adapting to its environment by finding detours around every blockade clinicians place in its path. A study from the lab of Nilay Sethi, MD, PhD, in Dana-Farber’s Center … Read more
Pancreatic cancer has long been difficult to detect and treat. Dana-Farber experts in the Hale Family Center for Pancreatic Cancer Research, however, are working to change that with research efforts in three key areas that are poised to advance early detection, early intervention, and treatment of the disease. They presented these topics for discussion with … Read more
Jessica St. Laurent, MD, was sure something had gone wrong. The results of an experiment she’d run showed that the cancer cells she was studying had abnormally high levels of a specific collection of proteins of interest to her team. “I remember seeing the gradient and thinking, This can’t be right,” says St. Laurent, who … Read more
Viruses aren’t thought of as living beings. Rather, they are collections of genetic instructions that hijack the replication machinery of living cells to perpetuate themselves. A specific type of virus called a retrovirus does this by integrating a DNA copy of its RNA genome into the host cell’s DNA. This capability has proven to be … Read more
Gene therapy and immunotherapy are both types of treatment for cancer and other diseases. They represent different approaches to disease therapy, though there is some overlap. What is gene therapy? Gene therapy is a way of treating or preventing disease by altering the genetic instructions within an individual’s cells. Most diseases aren’t caused by a … Read more
Linda Lane was still fatigued months after having COVID-19 in January of 2021. “I told my doctor that I had not been this tired since I had a newborn in the house,” says Lane, now 57 and living on Cape Cod. “That got her attention.” Her bloodwork came back with abnormal results. By May, the … Read more
A few years ago, Oscar Diep, a 33-year-old software engineer living in Weymouth, Mass., started needing blood transfusions more often to manage a blood disorder called beta thalassemia. He also noticed that it was becoming harder for the nurses to find a vein for his infusions. On top of this, Diep and his then girlfriend, … Read more
For a long time, the standard treatment for younger patients with newly diagnosed mantle cell lymphoma involved intensive chemotherapy, called induction therapy, followed by autologous stem cell transplant (ASCT, where the patient’s own stem cells are used), followed by maintenance therapy to help keep the cancer from coming back. Based on recent clinical research involving … Read more
What is TIL (tumor-infiltrating lymphocyte) therapy? Tumor-infiltrating lymphocyte, or TIL, therapy uses a patient’s own immune system T cells to fight cancer. The therapy involves removing T cells from a piece of the patient’s tumor – where the T cells have congregated after being alerted to the cancer – growing them outside the body, then … Read more
Like many teenagers, Isabella (Bella) Snow Fraser, 15, enjoys immersing herself in action role-play games online. Her favorite, Genshin Impact, allows participants to join an interstellar traveler as they seek their lost twin across a mysterious world of danger and unforeseen challenges. This futuristic fantasy in many ways mirrors Bella’s own life. After being diagnosed … Read more