From the time Lorna Brunelle was a child, belting songs into her hairbrush, she knew she belonged in the spotlight. Over the years, Brunelle’s passion for acting and singing evolved into a career in education and coaching. She opened a performing arts school and now owns a theater in her hometown of Middleborough, MA. When … Read more
As she got out of the car and waved goodbye to her husband and her mother, Margaret-Ann Simonetta’s shoulders stiffened with anxiety. It was April 2021, still in the height of the COVID-19 pandemic, and she was headed into Brigham and Women’s Hospital for a colectomy – a total surgical removal of her colon. With … Read more
If you look down at your stomach, glide your eyes diagonally from your belly button to the lower right side of your abdomen: that’s your appendix. It is a finger-shaped organ that stems from your colon. With two primary functions — supporting the immune system and potentially serving as a safe house for good bacteria, as theorized from some– the appendix is a small, but mighty organ that is important to take note of, especially given the recent … Read more
Cancer can make its way through the body by shapeshifting through even the narrowest places, like a skilled driver navigating traffic. It has a sly way of adapting to its environment by finding detours around every blockade clinicians place in its path. A study from the lab of Nilay Sethi, MD, PhD, in Dana-Farber’s Center … Read more
When Clelia Lavoie, then 49, began experiencing abdominal pain in 2019, she had a feeling it was something serious despite dismissals from her doctor. Lavoie’s intuition was right. A colonoscopy led to a diagnosis of stage IV colorectal cancer that had metastasized to her thyroid, back, and liver. She needed surgery to remove part of … Read more
Editor’s Note: Kathy Ball-Toncic completed her 162-mile PMC ride on Aug. 2-3, 2025. Since sharing her story, Kathy has continued to inspire others, including through her recent TEDx talk, “When Life Disrupts: Choosing Connection Over Fear,” where she reflects on survivorship, resilience, and the importance of showing up for one another. Nearly 1,300 cyclists will be … Read more
Dana-Farber’s Older Adult Gastrointestinal Cancer Program specializes in treating patients who are 65 and older and have gastrointestinal cancers, such as colorectal cancer, esophageal and gastric cancer, liver cancer, neuroendocrine and pancreatic cancer. “Older adults are richly complex and multidimensional,” says gastrointestinal and geriatric oncologist Nadine McCleary, MD, MPH, who leads the program. “They deserve … Read more
In recent decades, rates of some cancers, such as colorectal cancer, have been rising in young adults under the age of 50. One possible explanation for this rise is a parallel rise in obesity rates and changes in diet, activity levels and lifestyle. However, says Kimmie Ng, MD, MPH, director of Dana-Farber’s Young-Onset Colorectal Cancer … Read more
Clinicians and researchers have recognized a disturbing trend in recent years: colorectal cancer (CRC) in young people is skyrocketing. In individuals under the age of 50, the incidence of CRC has increased about 2% each year since the 1990s, and, according to the American Cancer Society, is now the leading cause of death in males … Read more
Andrew Ciardelli’s annual brothers’ hunting trip in Idaho took a turn for the worse when the stomach issues he had lived with for years suddenly became unbearable. Years before the trip, a urologist told Ciardelli that the cause of his pain and the blood in his stool was hemorrhoids. “They told me as long as … Read more
In trial after clinical trial, metastatic colorectal cancer has been largely undeterred by immune checkpoint inhibitors. Although these drugs have shown effectiveness in Hodgkin lymphoma, lung cancer, bladder cancer, kidney cancer, and nearly a dozen other malignancies, their track record against colorectal cancer has been lackluster, particularly for patients with the most common subtype of … Read more
Simone Ledward-Boseman has many roles: She’s a writer, artist, and singer. And for some time, she was a caregiver to her late husband, Chadwick Boseman, the actor known for playing Black Panther and groundbreaking figures like James Brown and Jackie Robinson. These days, Ledward-Boseman has added more titles to her list: activist and advocate. “I’m … Read more
Dana-Farber researchers have found that a transcription factor called SOX17 gives colon cancer a safe space to develop.
Stories of young adults being diagnosed with colorectal cancer are becoming more common as the rates continue to rise among adults between 20 and 49.
Colon and rectal cancer combined are the fourth most commonly diagnosed cancers. Eighty percent of patients are diagnosed at a stage of disease when treatment is given with curative-intent. However, treatment can have both short- and long-term side effects that may impact quality of life. To address these concerns, investigators at Dana-Farber have led clinical … Read more
Two weeks after turning 50, Wendy Tamis Robbins learned she had stage II colon cancer. Having lived with anxiety, obsessive compulsive disorder, and panic disorders nearly all her life, she used the same strategies that helped her navigate these struggles to meet her cancer diagnosis head-on. Robbins handled the ups and downs of her summer … Read more
Although hemorrhoids and colon cancer share certain symptoms, such as rectal bleeding, they are very different conditions. People who experience symptoms of either should get evaluated by a physician: while hemorrhoids are far more common than colon cancer, an exam is necessary to determine which one, if either, a patient has and how it should … Read more
For close to a year, Melanie Spears had been experiencing abdominal pain and constipation. As an Army veteran who had served in Afghanistan, she was used to pushing through adversity — so she tweaked her diet and dealt with what doctors diagnosed as irritable bowel syndrome. Only after microscopic blood samples in her stool led … Read more
Researchers in the late 1970s wanted to address challenges with a chemotherapy drug called floxuridine. It’s a form of chemotherapy invented in the 1950s that turns into its active form, 5-fluorouracil, or 5-FU, when metabolized. One challenge is that 5-FU has off-target effects, meaning it can damage healthy organs when given throughout the body. In … Read more
As a pediatric pharmacist located in Dana-Farber’s Jimmy Fund Clinic, Patrick never tires of seeing smiling, young cancer patients enjoying the clinic’s playroom. The resilience they display throughout infusions, blood draws, and other procedures not only inspires him, but it also serves as a source of resolve he carries into his ongoing cancer care. Patrick, … Read more