Research

The Latest Research and Treatment for Blood Cancers and Disorders

by

In the treatment of blood cancers and disorders, doctors and researchers are focusing their sights on the immune system and how to bolster its ability to fight off diseases like leukemia, lymphoma and multiple myeloma. “Understanding how you control the immune system is a big theme in treatment for these diseases,” says David A. Williams, … Read more

How Does Chemotherapy Work? Including Oral Chemotherapy and Immunotherapy

by

More than half of all people with cancer will get chemotherapy – powerful drugs that kill cancer cells to cure the disease, slow its growth, or reduce its symptoms. There are more than 100 different drugs used in chemotherapy, sometimes alone, but more often in combinations that have proven effective against specific types of cancer. … Read more

Precision Medicine for Lung Cancer Marks Tenth Anniversary

by

Ten years ago researchers at Dana-Farber and in Japan published a study showing that lung cancer patients whose tumors had a malfunctioning version of a protein called Epidermal Growth Factor Receptor (EGFR) responded dramatically to a drug that specifically targets the EGFR protein. The findings launched the era of precision medicine for lung cancer, transforming … Read more

Cancer Immunology at Dana-Farber

by

Immunotherapy – stimulating the body’s defenses to recognize and destroy disease-causing cells and proteins – was dubbed the “breakthrough of the year” in 2013 by Science magazine. Dana-Farber researchers have contributed many important discoveries over the years about how the immune system works. Now, they are building on these insights to develop immunotherapy against tumors – known as immuno-oncology.

In 2005 Dana-Farber established the Cancer Vaccine Center (CVC) under the leadership of Ellis Reinherz, MD, Jerome Ritz, MD, and Glenn Dranoff, MD. The mission of the CVC is to translate the promising insights from basic immunology into therapeutics that benefit cancer patients. The CVC undertook a series of clinical trials exploring the biologic activity of autologous tumor cell vaccines and antibodies targeting negative immunoregulatory pathways in patients. These investigations contributed to the foundation underlying the FDA approval of the first therapeutic cancer vaccine (Provenege) and the first antibody antagonizing a negative T cell checkpoint (ipilimumab).

Read more

What is Personalized Medicine?

by

Physicians have long recognized that the same disease can behave differently from one patient to another, and that there is no one-size-fits-all treatment.

In cancer, chemotherapy might dramatically shrink one lung tumor but prove ineffective against the same type of tumor in a different patient – even though tissue samples look identical under the microscope. Side effects and appropriate dosage may vary from patient to patient as well.

The goal of personalized medicine is to match a treatment to the unique characteristics of an individual patient: his or her personal and family medical history, age, body size, and other physical characteristics, and medical test results. But fundamentally, it is the DNA blueprint within cells that strongly influences a person’s risks of disease, how illnesses play out, which drugs are likely to be most effective and with the fewest side effects. This is where the newest phase of personalized medicine is heading.

Read more