The last thing Alan Rubin imagined he’d be doing after retiring from a successful career in financial services was helping his son run a hot dog cart. Then he was diagnosed with stage III kidney cancer, and found himself in another unexpected locale: Dana-Farber Brigham Cancer Center. Like the decision to join his son’s business … Read more
As science and clinical medicine advance, oncologists increasingly face the challenge of information overload. It can be hard for oncologists, especially those in community practices who cover many cancers, to keep up with the influx of new therapies, biomarkers, and clinical trial results. The go-to solution has been the systematic review. Researchers team up to … Read more
Although early detection and treatment advances have significantly improved survival rates for patients with prostate cancer, the majority will face some form of sexual health side effect. Addressing these physical and emotional side effects is a priority for care teams at Dana-Farber. But longstanding cultural barriers can often keep men from discussing sensitive issues like … Read more
Black men, particularly men of West African descent, are nearly twice as likely to be diagnosed with prostate cancer than Caucasian men, and three times more likely than Asian men. They are also twice as likely as Caucasian men to die from the disease. These disparities are among the largest in cancer. What is driving … Read more
People who inherit mutations in the BRCA1 or BRCA2 gene are at heightened risk for a variety of cancers, including breast, ovarian, prostate, and pancreatic. It’s estimated that one in 300-400 people in the general population carry a mutation in either of these genes. Among people of Ashkenazi (Eastern European) Jewish descent, the prevalence is … Read more
When Chuck Stravin was diagnosed with renal cell carcinoma in 2015, one of his biggest fears was not living long enough to see his four young daughters get married. The disease later metastasized to his lungs as stage IV cancer, but thanks to groundbreaking clinical trials and a care team he considers family, Stravin is … Read more
Overall, cancer death rates have declined by 33% since 1991, according to a Jan. 2023 American Cancer Society report. Multiple cancers like leukemia, melanoma, and kidney cancer have seen significant declines in mortality due to great advances in treatments. Prostate cancer rates had been on the decline for two decades, but the ACS report remarks that … Read more
Doug Kroc taught social studies for 40 years, but these days the retiree is more interested in making history than teaching it. Not the kind of events found in textbooks, but simple moments spent swimming and kayaking with his family or riding his bike along the backroads of Vermont. So when Kroc, 70, developed a … Read more
At 25, Fredrick Knight was unsure what to do when he felt an intense pain in his right testicle. He visited the local emergency room where he lived in Western Massachusetts and was told that the answer might be testicular torsion, a condition that occurs when a testicle rotates, reducing blood flow and causing pain. … Read more
Treating advanced prostate cancer typically involves surgery — to reduce levels of testosterone, which fuels the growth of tumors — or giving drugs that blockade the androgen receptor (AR), which responds to testosterone by stimulating cancer-growth genes. While these measures can keep the disease at bay initially, resistance almost always occurs as the androgen receptor … Read more
Prostate cancer screening options are available but are not necessarily recommended for all patients. There are positive and negative factors to consider when screening for this cancer, and options should be discussed with a doctor. Who should be screened for prostate cancer? The U.S. Preventive Services Task Force (USPSTF) recommends that people with prostates … Read more
Ureteral cancer is a type of cancer that grows in the ureter, or the two thin tubes that connect the kidneys to the bladder. It is uncommon compared with other cancers. What are the ureters? Kidneys make urine by filtering waste and extra water from blood. The urine travels from the kidneys to the bladder … Read more
Drugs that contain radioactive isotopes — forms of chemical elements that emit radiation — are known as radiopharmaceuticals. Radioisotopes have been used to treat cancer as far back as the 1940s, but the field has really taken off just in the past few years as researchers explore their potential in cancer. How are radiopharmaceuticals used … Read more
Stymied and disoriented. That’s one way to describe the state of the immune system in some patients with cancer. T cells revved up to attack tumors are turned into an army of loiterers. Cells keenly attuned to signals of infection or disease fail to pick up the faint notes of cancer. A clinical trial led … Read more
Discovering new cancer treatment can sometimes be a matter of connecting the dots between new pathways and old drugs. That was the case in a new paper in the TKTK issue of Clinical Cancer Research co-authored by Kent Mouw MD, PhD, co-director of Dana-Farber’s Bladder Cancer Center. Mouw and his team found a promising way … Read more
Chuck Stravin carries a white three-ring binder to all of his oncology appointments. Inside are his appointment notes, information about his treatment history, and the latest research and advancements regarding his disease. Nestled alongside these documents also sits a family photo of Stravin, his wife Liz, and their four daughters. Stravin’s family has been instrumental … Read more
A woman recently came to Bradley McGregor, MD, an oncologist at Dana-Farber Cancer Institute, in severe pain with extreme fatigue. Her squamous cell bladder cancer, a rare type for which traditional treatment is generally less effective, had advanced, and it appeared that she had no other options. But timing is everything. McGregor was conducting a … Read more
The management of advanced prostate cancer is rapidly evolving with the application of precision treatments based on genomic testing of tumors’ altered DNA. With recent biomarker-driven drug approvals and increased clinical use of genomic testing, there are a number of opportunities to expand upon this framework. Researchers are calling for increased collaboration and new strategies. … Read more
Husband and wife Ken Deutsch and Amy Green like to say they’re now “chasing the tail” of the bell curve. They have each had to grapple with cancer, as well as multiple setbacks and even recurrences. However, thanks to the care they’ve received at Dana-Farber — along with the support they’ve had from each other … Read more
Scientists are gratified when a clinical trial reveals whether one treatment — often an experimental therapy or drug combination — is superior to another. But researchers then often look more deeply into the data, searching for characteristics of tumors associated with a treatment’s effectiveness, or lack of it. In today’s world of precision medicine, identifying … Read more