PSA and PSMA: What is the Difference? 

Prostate cancer is the second most common cause of cancer in men worldwide as of 2020, and cases of advanced prostate cancer continue to rise.  Early detection of prostate cancer is essential for effective treatment. Dana-Farber physicians recommend having a conversation with a medical professional about screening around the age of 40, or perhaps even … Read more

​​​Retiree Relishing Life After Advanced Kidney Cancer Treatment 

The last thing Alan Rubin imagined he’d be doing after retiring from a successful career in financial services was helping his son run a hot dog cart.   Then he was diagnosed with stage III kidney cancer, and found himself in another unexpected locale: Dana-Farber Brigham Cancer Center. Like the decision to join his son’s business … Read more

Living Systematic Review Guides Prostate Cancer Treatment Options

As science and clinical medicine advance, oncologists increasingly face the challenge of information overload. It can be hard for oncologists, especially those in community practices who cover many cancers, to keep up with the influx of new therapies, biomarkers, and clinical trial results. The go-to solution has been the systematic review. Researchers team up to … Read more

Navigating the Mental Health Toll of Prostate Cancer and Its Side Effects 

Although early detection and treatment advances have significantly improved survival rates for patients with prostate cancer, the majority will face some form of sexual health side effect. Addressing these physical and emotional side effects is a priority for care teams at Dana-Farber.  But longstanding cultural barriers can often keep men from discussing sensitive issues like … Read more

What’s the Connection Between BRCA and Ashkenazi Jewish Ancestry? 

People who inherit mutations in the BRCA1 or BRCA2 gene are at heightened risk for a variety of cancers, including breast, ovarian, prostate, and pancreatic. It’s estimated that one in 300-400 people in the general population carry a mutation in either of these genes. Among people of Ashkenazi (Eastern European) Jewish descent, the prevalence is … Read more

Father with Stage IV Kidney Cancer Enjoys Wedding of a Lifetime

When Chuck Stravin was diagnosed with renal cell carcinoma in 2015, one of his biggest fears was not living long enough to see his four young daughters get married. The disease later metastasized to his lungs as stage IV cancer, but thanks to groundbreaking clinical trials and a care team he considers family, Stravin is … Read more

Prostate Cancer Rates Raise Concerns: What You Should Know

Overall, cancer death rates have declined by 33% since 1991, according to a Jan. 2023 American Cancer Society report. Multiple cancers like leukemia, melanoma, and kidney cancer have seen significant declines in mortality due to great advances in treatments.   Prostate cancer rates had been on the decline for two decades, but the ACS report remarks that … Read more

Metastatic Prostate Cancer Can’t Slow Down Grandfather

Doug Kroc taught social studies for 40 years, but these days the retiree is more interested in making history than teaching it. Not the kind of events found in textbooks, but simple moments spent swimming and kayaking with his family or riding his bike along the backroads of Vermont. So when Kroc, 70, developed a … Read more

Newly Identified Regulator in Prostate Cancer Cells Could Serve as Drug Target for Advanced Tumors

Treating advanced prostate cancer typically involves surgery — to reduce levels of testosterone, which fuels the growth of tumors — or giving drugs that blockade the androgen receptor (AR), which responds to testosterone by stimulating cancer-growth genes. While these measures can keep the disease at bay initially, resistance almost always occurs as the androgen receptor … Read more

Prostate Cancer Screening: What You Need to Know

Prostate cancer screening options are available but are not necessarily recommended for all patients. There are positive and negative factors to consider when screening for this cancer, and options should be discussed with a doctor.   Who should be screened for prostate cancer? The U.S. Preventive Services Task Force (USPSTF) recommends that people with prostates … Read more

What is Ureteral Cancer?

Ureteral cancer is a type of cancer that grows in the ureter, or the two thin tubes that connect the kidneys to the bladder. It is uncommon compared with other cancers. What are the ureters? Kidneys make urine by filtering waste and extra water from blood. The urine travels from the kidneys to the bladder … Read more

What Are Radiopharmaceuticals and How Are They Used in Cancer?

Drugs that contain radioactive isotopes — forms of chemical elements that emit radiation — are known as radiopharmaceuticals. Radioisotopes have been used to treat cancer as far back as the 1940s, but the field has really taken off just in the past few years as researchers explore their potential in cancer. How are radiopharmaceuticals used … Read more

Study Pairs Two Forms of Immunotherapy in Patients with Advanced Kidney Cancer

Stymied and disoriented. That’s one way to describe the state of the immune system in some patients with cancer. T cells revved up to attack tumors are turned into an army of loiterers. Cells keenly attuned to signals of infection or disease fail to pick up the faint notes of cancer. A clinical trial led … Read more

Resurrecting an Alternative Treatment for NER-Deficient Bladder Cancer Patients

Discovering new cancer treatment can sometimes be a matter of connecting the dots between new pathways and old drugs. That was the case in a new paper in the TKTK issue of Clinical Cancer Research co-authored by Kent Mouw MD, PhD, co-director of Dana-Farber’s Bladder Cancer Center. Mouw and his team found a promising way … Read more

Newly FDA-Approved Therapy Offers Kidney Cancer Patient a Path Forward

Chuck Stravin carries a white three-ring binder to all of his oncology appointments. Inside are his appointment notes, information about his treatment history, and the latest research and advancements regarding his disease. Nestled alongside these documents also sits a family photo of Stravin, his wife Liz, and their four daughters. Stravin’s family has been instrumental … Read more

Combination Immunotherapy Holds Promise for Patients with Rare Bladder Cancer

A woman recently came to Bradley McGregor, MD, an oncologist at Dana-Farber Cancer Institute, in severe pain with extreme fatigue. Her squamous cell bladder cancer, a rare type for which traditional treatment is generally less effective, had advanced, and it appeared that she had no other options. But timing is everything. McGregor was conducting a … Read more

The Latest Efforts in Precision Oncology for Advanced Prostate Cancer

The management of advanced prostate cancer is rapidly evolving with the application of precision treatments based on genomic testing of tumors’ altered DNA. With recent biomarker-driven drug approvals and increased clinical use of genomic testing, there are a number of opportunities to expand upon this framework. Researchers are calling for increased collaboration and new strategies. … Read more