Medically reviewed by Alexander Gusev, PhD A team of Dana-Farber scientists and their associates has identified 34 genes associated with an increased risk of developing earliest-stage ovarian cancer. The findings, published in the journal Nature Genetics, will both help identify women who have the highest risk of developing ovarian cancer and pave the way for identifying … Continued
Medically reviewed by Kevin Elias, MD Today, cervical cancer is the only type of gynecologic cancer for which there is a routine screening test. The lack of such tests for endometrial and ovarian cancer — the most common gynecologic cancers — makes it especially important that women and their doctors be attuned to the symptoms … Continued
By Luisa Stigol, MD, FAAP I was a 74-year-old pediatrician in practice with a multi-specialty group associated with Boston Children’s Hospital. Forty years after becoming a doctor, I still loved learning new things and sharing them with my patients. Then I was diagnosed with ovarian cancer — and suddenly, a big wall separated me from … Continued
About 5 to 10% percent of women with breast cancer have an inherited mutation in the BRCA1 or BRCA2 gene, which puts them at greater risk for developing breast and ovarian cancers. For most women diagnosed with early-stage breast cancer, having a BRCA mutation doesn’t affect how the cancer itself is treated. But the presence … Continued
In the annals of patients who have benefited from Dana-Farber and Brigham and Women’s Hospital’s (BWH) genomic sequencing program Profile, few involve a turnabout as dramatic as one recently reported in Gynecologic Oncology. Authored by nearly a dozen Dana-Farber and BWH faculty, the paper recounts the medical history of a 49-year-old Nebraska woman first diagnosed … Continued
Learning that you have breast cancer can be overwhelming. In the shock of a diagnosis, it may be hard to organize your thoughts or plan out your questions. But those questions are important, and there are likely to be many of them. The answers will have an impact on your treatment and the preparations you … Continued
It was a bumpy road for Anne Sandstrom at first: after dealing with a stage IIIc ovarian cancer diagnosis, she had two relapses in a three-year span. But finally, treatment worked, and Sandstrom has enjoyed 16 years in which her disease lay dormant — enough for her oncologist to declare her “graduated” in 2017. The … Continued
Surgery is an essential component in the management of patients with gynecologic cancers. Surgical procedures may be utilized to initially diagnose cancers of the uterus, cervix, ovary, vulva and vagina. In addition, many gynecologic cancers are primarily treated (and often cured) with surgery alone. Nearly all gynecologic surgeries fall into either one of two categories: … Continued
Endometriosis is a non-cancerous disorder that occurs when tissue lining the inside of the uterus, known as the endometrium, appears in other parts of the body. It usually is found in the lower abdomen or pelvis but can appear in virtually any organ or tissue. Endometrial cancer, by contrast, occurs when cells in the endometrium … Continued
Media reports on the effect of diet and physical activity on breast cancer risk can be head-spinning. One report may suggest that eating a particular food—broccoli, for example—can help prevent breast cancer. Another may conclude that a substance within that same food actually promotes the disease. How can you sort out the often conflicting and … Continued
Like many forms of cancer, the risk of developing breast cancer increases with age: 30 percent of breast cancer patients in the United States are age 70 or older. For many older patients, the issues and challenges associated with the disease are quite different from those that arise in younger women. Older women are more … Continued
Kaitlyn Zonfrelli thought she was too young to have breast cancer, even though she showed a common sign of the disease. Now that she’s in treatment, she wants to spread the word: don’t ignore the signs, no matter what. Two years ago, when she was 26, Zonfrelli felt a lump on her breast during a … Continued
On the strength of the results of a major international clinical trial, there is now a new standard of care for patients with an advanced form of ovarian cancer who have responded to initial chemotherapy. The trial, dubbed SOLO-1, found that these patients – newly diagnosed with ovarian cancer that carries a mutation in the … Continued
Krista Lawrence likes to joke with her two adult children that they don’t need to get married and have their own kids just because she has metastatic breast cancer. In fact, thanks to her excellent response to a clinical trial at the Susan F. Smith Center for Women’s Cancers at Dana-Farber, Lawrence is enjoying each … Continued
When Stacy Hanson was diagnosed with metastatic breast cancer in early 2017, she immediately assumed she had no viable treatment options. Now that she is living a full, active lifestyle with her incurable yet treatable disease, she wants others to know that they can, too. Hanson, 49, is on a clinical trial that she began … Continued
One of the primary goals of breast cancer research is to personalize the treatment of the disease, tailoring therapies to the specific characteristics of each patient’s cancer. “The future of breast cancer therapy is tied to the idea of individualizing treatment for each patient—not only to the stage and subtype of the cancer but also … Continued
In recent years, there has been a dearth of clinical trials studying new approaches to how endometrial cancer, which forms in the lining of the uterus, is treated. That is changing rapidly, however, as basic research into the disease spurs the testing of novel drugs and drug combinations. A host of clinical trials—including four led … Continued
Vaginal bleeding—also known as spotting—between periods is common among women who have not yet reached menopause. Most commonly, it is caused by hormonal imbalances, stress, and vaginal dryness. Vaginal bleeding in post-menopausal women can, in some cases, be an early sign of cancer and should always be investigated further. Spotting is the primary symptom of … Continued
The drive from Plymouth, Massachusetts, to Raleigh, North Carolina, is about 750 miles. If you’re up for the drive, Jenn Anderson notes, plan on spending a lot of time on I-95 and consider extending the trip with a stopover in Delaware. It’s a familiar route for Anderson, who was planning to move south with her … Continued
Tests on living “organoids” created from patients’ ovarian cancer cells proved more accurate than DNA sequencing in predicting tumors’ sensitivity or resistance to chemotherapy drugs – and combining the two methods worked even better, say scientists at Dana-Farber Cancer Institute. The investigators report in Cancer Discovery that ovarian cancer organoids – tiny, three-dimensional spheres of cells … Continued
