Basic Science Discovery Leads to Clinical Trial for Patients with Chemotherapy-Resistant Form of Ovarian Cancer

Dana-Farber scientists recently uncovered a potential vulnerability in a form of ovarian cancer notoriously resistant to chemotherapy. Now they’ve opened a clinical trial involving a drug that targets that susceptibility in patients with the disease. The impetus for their research is a type of ovarian cancer with excess copies of the cyclinE1 gene (abbreviated CCNE1). … Continued

Scientists Identify Genes Tied to Increased Risk of Ovarian Cancer

Medically reviewed by Alexander Gusev, PhD A team of Dana-Farber scientists and their associates has identified 34 genes associated with an increased risk of developing earliest-stage ovarian cancer. The findings, published in the journal Nature Genetics, will both help identify women who have the highest risk of developing ovarian cancer and pave the way for identifying … Continued

Gynecologic Cancer Screening: What You Need to Know

Medically reviewed by Kevin Elias, MD Today, cervical cancer is the only type of gynecologic cancer for which there is a routine screening test. The lack of such tests for endometrial and ovarian cancer — the most common gynecologic cancers — makes it especially important that women and their doctors be attuned to the symptoms … Continued

Facing Ovarian Cancer, a Doctor Becomes the Patient

By Luisa Stigol, MD, FAAP I was a 74-year-old pediatrician in practice with a multi-specialty group associated with Boston Children’s Hospital. Forty years after becoming a doctor, I still loved learning new things and sharing them with my patients. Then I was diagnosed with ovarian cancer — and suddenly, a big wall separated me from … Continued

With precision cancer medicine, a success against endometrial cancer

In the annals of patients who have benefited from Dana-Farber and Brigham and Women’s Hospital’s (BWH) genomic sequencing program Profile, few involve a turnabout as dramatic as one recently reported in Gynecologic Oncology. Authored by nearly a dozen Dana-Farber and BWH faculty, the paper recounts the medical history of a 49-year-old Nebraska woman first diagnosed … Continued

Longtime Ovarian Cancer Survivor Sings a Song of Hope

It was a bumpy road for Anne Sandstrom at first: after dealing with a stage IIIc ovarian cancer diagnosis, she had two relapses in a three-year span. But finally, treatment worked, and Sandstrom has enjoyed 16 years in which her disease lay dormant — enough for her oncologist to declare her “graduated” in 2017. The … Continued

Tips for Recovery After Gynecologic Surgery

Surgery is an essential component in the management of patients with gynecologic cancers. Surgical procedures may be utilized to initially diagnose cancers of the uterus, cervix, ovary, vulva and vagina. In addition, many gynecologic cancers are primarily treated (and often cured) with surgery alone. Nearly all gynecologic surgeries fall into either one of two categories: … Continued

How is Endometriosis Different from Endometrial Cancer?

Endometriosis is a non-cancerous disorder that occurs when tissue lining the inside of the uterus, known as the endometrium, appears in other parts of the body. It usually is found in the lower abdomen or pelvis but can appear in virtually any organ or tissue. Endometrial cancer, by contrast, occurs when cells in the endometrium … Continued

Trials Open New Avenues of Endometrial Cancer Treatment

In recent years, there has been a dearth of clinical trials studying new approaches to how endometrial cancer, which forms in the lining of the uterus, is treated. That is changing rapidly, however, as basic research into the disease spurs the testing of novel drugs and drug combinations. A host of clinical trials—including four led … Continued

What are the Signs and Symptoms of Endometrial Cancer?

Endometrial cancer—sometimes referred to as uterine cancer—is the most common cancer of the female reproductive organs. Approximately 63,000 diagnosed in the U.S. alone each year. Mainly affecting postmenopausal women, endometrial cancer occurs when cancer cells form in the tissues of the endometrium, or the lining of the uterus. Symptoms of endometrial cancer include: Bleeding or … Continued

Study Finds Source of PARP Inhibitor Drug Resistance

It may not be sporting to hit someone when they’re down, but when the foe is a cancer cell, there’s no merit in mercy. That’s the principle behind drugs known as PARP inhibitors. Tumor cells that lack effective BRCA genes have difficulty repairing certain kinds of DNA damage, potentially leaving them vulnerable to agents that … Continued

‘Organoids’ Could Aid Cancer Drug Selection

Tests on living “organoids” created from patients’ ovarian cancer cells proved more accurate than DNA sequencing in predicting tumors’ sensitivity or resistance to chemotherapy drugs – and combining the two methods worked even better, say scientists at Dana-Farber Cancer Institute. The investigators report in Cancer Discovery that ovarian cancer organoids – tiny, three-dimensional spheres of cells … Continued

After Two Relapses, Ovarian Cancer Patient is Thriving

After two relapses, Janet Sheehan went on a clinical trial for her ovarian cancer. Four months later, her newest tumors were completely gone—and today, she’s relishing in a growing list of family milestones.

Infections and Cancer: What You Should Know

Common infections, such as those that cause the common cold, do not cause cancer or make cancer more likely to occur. However, infections with specific types of viruses, bacteria, or parasites can increase an individual’s risk for certain kinds of cancer.