Trials Open New Avenues of Endometrial Cancer Treatment

In recent years, there has been a dearth of clinical trials studying new approaches to how endometrial cancer, which forms in the lining of the uterus, is treated. That is changing rapidly, however, as basic research into the disease spurs the testing of novel drugs and drug combinations. A host of clinical trials—including four led … Continued

What are the Signs and Symptoms of Endometrial Cancer?

Endometrial cancer—sometimes referred to as uterine cancer—is the most common cancer of the female reproductive organs. Approximately 63,000 diagnosed in the U.S. alone each year. Mainly affecting postmenopausal women, endometrial cancer occurs when cancer cells form in the tissues of the endometrium, or the lining of the uterus. Symptoms of endometrial cancer include: Bleeding or … Continued

Study Finds Source of PARP Inhibitor Drug Resistance

It may not be sporting to hit someone when they’re down, but when the foe is a cancer cell, there’s no merit in mercy. That’s the principle behind drugs known as PARP inhibitors. Tumor cells that lack effective BRCA genes have difficulty repairing certain kinds of DNA damage, potentially leaving them vulnerable to agents that … Continued

‘Organoids’ Could Aid Cancer Drug Selection

Tests on living “organoids” created from patients’ ovarian cancer cells proved more accurate than DNA sequencing in predicting tumors’ sensitivity or resistance to chemotherapy drugs – and combining the two methods worked even better, say scientists at Dana-Farber Cancer Institute. The investigators report in Cancer Discovery that ovarian cancer organoids – tiny, three-dimensional spheres of cells … Continued

After Two Relapses, Ovarian Cancer Patient is Thriving

After two relapses, Janet Sheehan went on a clinical trial for her ovarian cancer. Four months later, her newest tumors were completely gone—and today, she’s relishing in a growing list of family milestones.

Infections and Cancer: What You Should Know

Common infections, such as those that cause the common cold, do not cause cancer or make cancer more likely to occur. However, infections with specific types of viruses, bacteria, or parasites can increase an individual’s risk for certain kinds of cancer.

Living with Ovarian Cancer as a Chronic Disease, and Celebrating Milestones

Whenever Joan Janssen meets fellow ovarian cancer patients, she shares words of wisdom that she’s gained from seven years of living with the disease. “This is a recurring disease; don’t be stunned if it comes back,” she tells them. “You fought it the first time. You can do it even better the next time.” Janssen … Continued

New Interventions Address Sexual Health after Ovarian Cancer Treatment

Ovarian cancer often goes undetected before it reaches more invasive stages, but there is one aspect of the disease that frequently remains ignored even after diagnosis: Its impact upon a patient’s sexual health and function. Now, as research and treatment advances are allowing more women to live longer and healthier with ovarian cancer, Dana-Farber is … Continued

Human Touch Surgeries, New Therapies Brighten the Picture in Endometrial Cancer

Although she had been fully prepped on what to expect, Barbara Losordo was a bit surprised at the ease and speed of her recovery from surgery for endometrial cancer. Discharged from the hospital the same day she had undergone the procedure, she needed no pain medication afterward. Within a week, she was driving. Within a month, … Continued

Testing a New Option in Ovarian Cancer Prevention

For women who inherit a breast and ovarian cancer susceptibility gene like mutant BRCA-1 or BRCA-2, the risk of ovarian and tubal cancers begins to rise significantly at age 40 to 45. Women at this age — and younger — are often advised to have their ovaries and tubes removed as a risk-reducing strategy for … Continued

Advanced Ovarian Cancer: 4 Things to Know

By Linda Dzobiek I have been living with ovarian cancer for 13 years. I was diagnosed at age 53 with Stage 3C ovarian cancer, and after receiving care near my home in Providence, Rhode Island, my doctor referred me to Dana-Farber’s Susan F. Smith Center for Women’s Cancers for a clinical trial. I have been … Continued

Ovarian Cancer Can Present Unique Challenges Around Gender

By Mal Malme Each year during my annual checkup with my wonderful oncologist Panos A. Konstantinopoulos, MD, PhD, at the Susan F. Smith Center for Women’s Cancers at Dana-Farber, I reflect back on how grateful I am that my ovarian cancer is in remission. And while I appreciate the warmth and clinical expertise that he … Continued

Ovarian Cancer and Immunotherapy: The State of the Science

Immunotherapy has revolutionized the treatment of many types of cancer and is now undergoing testing in ovarian cancer. Clinical trials of drugs known as immune checkpoint inhibitors, which can unleash a potent immune system attack on cancer cells, have produced remissions in about 10-15 percent of patients with advanced and recurrent ovarian cancer – somewhat … Continued

New Online Tool Guides Genetic Testing for Lynch Syndrome

A new online assessment tool developed at Dana-Farber can help rapidly identify people who should undergo genetic testing for Lynch syndrome, an inherited disorder that greatly increases the lifetime risk of colorectal, endometrial, ovarian, stomach, and other cancers. An estimated 1 in 279 individuals – nearly a million people in the United States – carry … Continued