Should I Be Screened for Pancreatic Cancer?

Medically Reviewed By: Sapna Syngal, MD, MPH
  • People should be screened for pancreatic cancer if they test positive for an inherited gene mutation linked to the cancer and if they have at least two relatives who have had the disease.
  • A new nationwide study is exploring whether increasing the accessibility of genetic testing results in higher screening rates.

While screening for pancreatic cancer is not recommended for people at average risk of the disease, screening is recommended for those who carry an inherited genetic mutation associated with pancreatic cancer and have a family history of the disease. (Mutations are abnormal stretches of DNA that alter how cells grow and divide.)

People with an inherited predisposition to pancreatic cancer have an 8-15% chance of developing the disease during their lifetime — a risk that, though low, is substantially higher than that of the general population.

Recent studies have found that inherited mutations linked to pancreatic cancer, which had been thought to be quite rare, actually account for as many as 10% of all cases of the disease.

Current guidelines call for screening of people in either of these categories:

  • Those who test positive for an inherited mutation in a gene linked to pancreatic cancer and have a family member with a history of the disease. The most common of these genes are BRCA1, BRCA2, PALB2, CDKN2A, and genes associated with Lynch syndrome.
  • Those with two or more relatives who have been diagnosed with pancreatic cancer.

People who meet these criteria should be screened annually for pancreatic cancer beginning at age 50, or 10 years earlier than the age at which a family member was diagnosed with the disease, the guidelines say. (When pancreatic occurs as a result of an inherited mutation, it tends to occur later in life than other cancers linked to inherited mutations, such as breast and ovarian cancer. As a result, the recommended age for beginning screening is later than it is for those other cancers.)

Are there any other factors that increase the risk of pancreatic cancer?

Pancreatic cancer rates are higher among African Americans and cigarette smokers. But in neither case is the increased risk high enough that routine screening would be beneficial, studies show.

Sapna Syngal, MD.

What are the early warning signs of pancreatic cancer?

Because the pancreas (which regulates sugar levels and assists in digestion) is located deep within the body, cancer of the gland often doesn’t produce symptoms in its earliest stages. The vast majority of patients are not diagnosed until the disease has reached an advanced stage, when it has already metastasized and is very difficult to treat successfully.

The most common potential symptoms of pancreatic cancer are:

  • Abdominal pain
  • Newly developed jaundice
  • Depression

But because these can be related to a variety of conditions other than pancreatic cancer, it’s important for people experiencing them to be evaluated by a physician.

Another potential early sign of pancreatic cancer is the onset of diabetes at a later age in people with none of the normal risk factors for diabetes, such as obesity or high blood pressure.

By identifying people at increased risk of pancreatic cancer because of an inherited susceptibility to the disease, doctors can monitor them more closely to detect the disease at its earliest stages, when it can most successfully be treated.

In families with a history of multiple cases of pancreatic cancer, who should be tested for an inherited mutation associated with the disease?

Anyone at risk of having inherited the mutation should be screened. That may include siblings, children, aunts, uncles, cousins, nieces, and nephews of the affected individual.

If I’ve been diagnosed with pancreatic cancer, should I be tested for an inherited predisposition to the disease?

Current recommendations call for anyone diagnosed with pancreatic cancer to be tested for inherited mutations for the disease. If a patient tests positive for these mutations, his or her family members should undergo genetic testing as well.

What tests are currently used to screen for pancreatic cancer?

Two types of imaging tests are used in screening for the disease:

  • Magnetic Resonance Imaging (MRI), which passes radio waves through a magnetic field to make images of internal organs. A related test, known as Magnetic Resonance Cholangiopancreatography (MRCP), uses MRI to make images specifically of the bile and pancreatic ducts.
  • Endoscopic ultrasound, which combines an endoscope (a flexible tube that can be threaded into an organ) and ultrasound, which uses high-frequency sound waves to make detailed images of the inner lining of organs.

If either of these methods reveals a suspicious growth in the pancreas, a tissue sample can be biopsied, or removed with an ultra-fine needle for examination by a pathologist. The pathologist’s exam ultimately determines if cancer is present.

What can be done to increase screening rates of people with a family history of pancreatic cancer?

One of the biggest obstacles to genetic testing is that it has traditionally been offered only at major cancer centers, which may be located far from where people live. To address that problem, Dana-Farber investigators have joined colleagues at four other institutions to launch the Generate study, which seeks to determine whether making genetic screening more accessible can spur more people to use screening services and learn about inherited risk.

The study is open to adults with a blood relative who has, or had, pancreatic cancer that was caused by an inherited gene mutation, but have not had the disease themselves. Participants take an online educational program about genetic testing, mail in a saliva sample for genetic testing, and complete a set of questionnaires over the following 15 months. More information on the study, which people can join at no cost, is available by contacting the study team at

About the Medical Reviewer

Sapna Syngal, MD, MPH

Dr. Syngal received her MD from McGill University in 1990 and completed her clinical training in Internal Medicine and Gastroenterology at Brigham and Women's Hospital. She received her MPH from Harvard School of Public Health and completed a research fellowship at the Harvard Education Program in Cancer Prevention. She joined DFCI in 1995.

9 thoughts on “Should I Be Screened for Pancreatic Cancer?”

  1. THANK YOU FOR THE ON GOING RESEARCH .MY MOM DIED OF PANCREATIC CANCER 1994 19 days after her diagnosis. 6 of her 10 siblings died of lynch syndromecrelated cancers, of course not knowing back then. I have spent my whole life living holistically eating clean, avoiding toxins onlybto find out at 53 years old that i had uterine cancer andcthen of cnurse lynch syndrome. I AM CURRENTLY 1 YEAR SURVIVOR! Living as a pre-vivor, deeply in fear of pancreatic cancer. Thank you for all your work and for sharing all the info with me via facebook. it gives me great hope for my future. ❤️?

  2. My mom was tested positive for Lynch Syndrome MSH6 and negative for both BRCA at age 72 with her third cancer. She had a twenty year history of four seperate cancers with her last cancer being pancreatic. As far as I’m aware, none of her tumors were tested if Lynch caused or sporadic cancers. At age 74 she passed. I believe they were Lynch related cancers, as there is little history on her dads side of the family. He passed in his mid seventies with a liver illness?
    I was tested positive for the exact gene mutation MSH6 at 49 (currently I’m 54) I’m a previvor (never had cancer). Could I be s candidate for this study?

  3. My husband has stage 1 pancreatic cancer. He has gone thru chemo radiation and headed to surgery. Would he have been tested for inherited mutations automatically or should we request it be done?

    • Hi Maureen,

      Testing for inherited mutations is generally not automatically done without specific informed consent for the testing. If you do not recall a discussion regarding the testing, it would be advisable to discuss it with your husband’s doctors and request it.

      Wishing you the best,

  4. My wife died from Pancreatic cancer Feb 22 2019 after being diagnosed June 2018. She was subjected to multiple rounds of chemo starting 6/8/ 2018 thru to 8/28/2018 followed by Rt treatments 8/20/2018 thru 8/31/2018.
    She started another round of chemo 9/4/2018 to 9/25/2018 with Rt sessions 9/4/2018 to 9/28/2018.
    CT scan taken 10/17/2018 revealed tumor had not deminished in size but had increased in size.
    She was then offered additional Rt but could no longer physically continue and elected hospice to manage the increase in pain and let nature to take it’s course and concentrate on spending the remainder of her time with family and friends
    She passed with family at he’d bedside comforting her and bidding farewell, not goodbye on Feb 22 2019

    • Hi Robert,

      Thank you for sharing this, and we are so sorry to hear about your wife’s passing.

      Wishing you all the best,

  5. 58 yr old daughter recently within one yr diagnosed w celiac disease and has been On a gluten-free diet since then. She contracted diabetes and found it Sometimes fall is a diagnosis of celiac disease. Should she be tested for Pancreatic cancer as outlined in the article. There is no known diabetes in our family both paternal or maternal.

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