How is Endometriosis Different from Endometrial Cancer?

Endometriosis is a non-cancerous disorder that occurs when tissue lining the inside of the uterus, known as the endometrium, appears in other parts of the body. It usually is found in the lower abdomen or pelvis but can appear in virtually any organ or tissue. Endometrial cancer, by contrast, occurs when cells in the endometrium … Read more

Overriding Resistance to Epigenetic Inhibitors in Neuroblastoma: Targeting PI3K

This post originally appeared on Vector, Boston Children’s Hospital’s science and clinical innovation blog. Children’s cancers pose unique challenges. They’re not caused by the same kinds of genetic mutations that cause adult cancers, and only a minority of their mutations can be targeted with drugs. In a recent study, Kimberly Stegmaier, MD, at Dana-Farber/Boston Children’s Cancer … Read more

Common Questions About Alternative and Integrative Therapies, Answered [Podcast]

The search for new and better cancer treatments has resulted in some incredible discoveries in recent years. Immunotherapy, a kind of cancer therapy that harnesses the immune system to fight cancer, has monumentally changed the way that some cancers are treated. Chemotherapy and radiation have greatly improved. And researchers are working on bringing more treatment … Read more

How Does Chemotherapy Affect Cancer Cells?

Chemotherapy agents can be divided into three major classes, based on the manner in which they act on cancer cells: Drugs that are active against dividing cells by targeting a specific phase of the cell cycle—the process by which cells duplicate their DNA and separate into two daughter cells. Drugs that are active against dividing … Read more

Now in Remission, Pediatric Cancer Patient is Inspiration for Her Family

Kids often rely on their parents for inspiration, but for Kevin and Becky McAvoy, it’s their five-year-old daughter Avery who provides the spark. Avery was less than a year old when she was diagnosed with metastatic neuroblastoma, the most common type of cancer in infants. Her cancer contained an anaplastic lymphoma kinase (ALK) mutation. The … Read more

What Causes Cancer to Spread?

When cancer spreads in the body, it is first and foremost due to changes, or mutations, in the DNA of cells. Because of a mutation or other abnormality in a cancer cell’s genome (the DNA stored in its nucleus), the cell may become separated from its neighbors and invade surrounding tissue. Other genomic breakdowns allow … Read more

Scan Anxiety (or ‘Scanxiety’): 5 Approaches to Coping

Irritability, sweaty palms, increased heart rate, and nausea are common symptoms many patients experience when preparing for an upcoming exam. This feeling of apprehension and discomfort is called scanxiety, which aptly refers to the anxiety or worry patients often feel before undergoing a scan or receiving the results of an examination. “Anxiety often comes when … Read more

What is a Balanced Diet?

A balanced diet promotes health and wellness in everyone, including people with cancer. By properly balancing your plate and adopting (or dropping) certain eating habits, you’ll be ensuring that your body is getting the nutrition that it needs to function well. An accurately balanced plate of food will consist of 50 percent fruits and vegetables, 25 … Read more

Parents of Two-Year-Old Hepatoblastoma Survivor Enjoying Every Milestone

Steph and Jake Holbrook know the date of every important moment in their son’s life: William’s first steps, his first words, and even his first Boston Red Sox game. Another date they’ll forever remember: Jan. 17, 2018, when they were told that William—then 10 months old—had a rare type of liver cancer. “I couldn’t believe … Read more

Chemotherapy Myths and Misconceptions [Podcast]

Chemotherapy has long been a mainstay of cancer treatment. But a lot has changed since Sidney Farber, MD, the founder of Dana-Farber Cancer Institute, achieved the first remissions for pediatric leukemia using chemotherapy in the 1940s. Today, in the era of precision cancer medicine, there are newer treatments and chemotherapy that can more specifically target … Read more

What is Neoadjuvant Chemotherapy?

Chemotherapy has been traditionally used as an “adjuvant” treatment in many patients with cancer — administered after surgery to kill microscopic tumor cells that remain in the body after surgical removal of the tumor. More recently, it has also come to be used in a “neoadjuvant” setting — to shrink tumors before they are surgically … Read more

Can Immunotherapy be Combined with Chemotherapy to Fight Cancer?

Immunotherapy drugs can be more effective against cancer when combined with other therapies, such as radiation therapy, targeted drugs, or other immunotherapy agents. Clinical trials that are currently underway are testing such combinations in a variety of cancers. It might seem that immunotherapy and chemotherapy make an unpromising pair. Chemotherapy, after all, is known to … Read more