What Is the Difference Between Hodgkin Lymphoma and Non-Hodgkin Lymphoma?

Checking lymph nodes

Although the diseases may sound similar, there are a variety of differences between Hodgkin and non-Hodgkin lymphoma. We spoke with Arnold Freedman, MD, of the Adult Lymphoma Program at Dana-Farber, to learn more. Both Hodgkin and non-Hodgkin lymphoma are malignancies of a family of white blood cells known as lymphocytes, which help the body fight off infections and other diseases. Hodgkin lymphoma is marked by the presence of Reed-Sternberg cells, which are mature B cells that have become malignant, are unusually large, and carry more than one nucleus. The first sign of the disease is often the appearance of enlarged …

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Five Things You Need to Know About Penile Cancer

Mark Preston, MD

Penile cancer is a rare disease, affecting just 1 in 100,000 men in North American and Europe, in which malignant cells form in the tissues of the penis. While not common in the United States, it can account for up to 10 percent of male cancers in parts of Asia, South America, and Africa. Here are five things you should know about penile cancer. What are the risk factors for penile cancer? Men older than 60 and those with poor personal hygiene, who have many sexual partners, or use tobacco products, are at a higher risk of developing penile cancer. Uncircumcised …

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What’s New in Pediatric Brain Tumor Treatment?

Mark Kieran, MD, PhD

As one of the most difficult cancers to treat, childhood brain tumors are the leading cause of cancer-related deaths in children under age 10. However, researchers are making more progress than ever before. “Over the last 10 years there has been a lot of excitement about new treatments for pediatric brain tumors,” says Peter Manley, MD, a pediatric neuro-oncologist with Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and director of the Stop & Shop Family Pediatric Neuro-Oncology Outcomes Clinic. “We’re looking at brain tumors on a molecular level to find potential targeted therapies that can not only treat the cancer, …

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Why the Pan-Mass Challenge Is My Kinetic Karma

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By Dave Lafreniere I rode in my first Pan-Mass Challenge (PMC) the day my mother died. She was a two-time breast cancer survivor who developed an unrelated, rare ocular melanoma while I was training. She passed away in the early morning of August 2, 2002, as I sat by and held her hand. After feeling her heart beat its last, I picked up my bike and headed out to the Wellesley starting line. Getting through that first PMC was much easier than I expected. I was alone, I was grieving, but once I got on the road people were very …

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What Is the Link Between Diet and Melanoma?

By Stacy Kennedy, MPH, RD When it comes to sun safety, lathering on sunscreen, sporting broad-brimmed hats and staying in the shade surely come to mind. But diet may also play a key role in the prevention of skin cancer and melanoma. Here is some information on the emerging research around obesity, antioxidant intake, vitamin D and other potential nutrition-related links to melanoma. Obesity & Melanoma At any age, maintaining a healthy weight is one of the most important strategies for cancer prevention, including melanoma. While there have not been many in-depth studies on the topic, obesity is emerging as …

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Super Bowl Champion Joe Andruzzi Shares His Cancer Experience

Joe Andruzzi

With six surgeries, multiple injuries, and many knee problems by the time he was 31 years old, three-time Super Bowl champion Joe Andruzzi was no stranger to doctors. But when the former New England Patriots player started experiencing stomach pains in May 2007, everything quickly changed. He and his wife, Jen, recently shared their experience at Dana-Farber’s 12th annual Young Adult Cancer Conference. Everything was put on hold. Joe: I had just finished my tenth year in the NFL, and was ready to train and show people I still had something in the tank, because you get old really fast …

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Science Illustrated: How Is Immunotherapy Used to Fight Cancer?

Immunotherapy, including the vitally important discovery of PD-1/PD-L1, is one of the most promising areas of cancer research today. One immunotherapy strategy  is to use checkpoint inhibitors to “take the brakes off” the immune system and unleash an attack on cancer cells. Learn about PD-1 and PD-L1, and how immunotherapy can be used fight cancer:

Do Childhood Cancer Survivors Have a Higher Risk of Developing Cancer Later in Life?

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During cancer treatment, patients are often focused on just one thing: getting healthy. But for survivors, particularly of childhood cancer, it’s also important to learn about staying healthy after treatment, including prevention of new cancers that may occur later in life. We spoke with Lynda Vrooman, MD, associate medical director of the David B. Perini, Jr. Quality of Life Clinic at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center: Do childhood cancer survivors have an increased risk for developing a second cancer later in life (not just a recurrence)?  There are many factors that need to be taken into account when …

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Metastatic Breast Cancer Patient Keeps on Riding

Every day, Pat Hastings is in the barn by 5 a.m. As steward of the Hamilton Rare Breeds Foundation in Hartland, Vt., Hastings oversees herds of Poitou donkeys, Choctaw mustangs, Dales ponies, and American Cream draft horses. She has worked on farms for 35 years, and it’s here, with her horses, that she recovers from treatments for metastatic breast cancer. “Animals and farming are in my blood,” she says. First diagnosed with inflammatory breast cancer in April 1998, Hastings had a radical mastectomy at a hospital near her home in Vermont. Eleven years later, she felt a lump in the …

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Know Your Surroundings: How Cancer Treatments Can Keep Cells From Supporting Tumors

By Eric Bender Multiple myeloma is a poster child for recent advances in treatment: In the past decade, the U.S. Food and Drug Administration (FDA) approved no fewer than nine treatments for the blood cancer, and several more drug approvals appear to be near. Not coincidentally, multiple myeloma is also a popular target that researchers use to study the interactions of tumor cells and their “tumor microenvironments” — the non-cancerous cells, molecules and blood vessels that surround and often support the malignant cells. “These new myeloma drugs are all based on understanding how the tumor cells interact with other cells …

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