Increasingly, transgender youth and adults are undergoing (or planning) gender-affirming surgery and taking masculinizing or feminizing hormones. If they have cancer, these treatments can have implications for their care, and cancer treatments in turn can have implications for their gender-affirming care. Oncologists should take gender identity into account in making decisions about cancer treatment. This … Continued
By Ursula Matulonis, MD, Director, Gynecologic Oncology, Susan F. Smith Center for Women’s Cancers at Dana-Farber Immunotherapy, which has revolutionized the treatment of many types of cancer, is undergoing extensive study in patients with ovarian cancer. Although much of this research is in the early stages, it has produced some intriguing findings about the promise … Continued
Many of the drugs that have become mainstays of cancer treatment are based on antibodies — artificial proteins that latch onto a molecular target called an antigen. When an antibody binds to an antigen on a cancer cell, it attacks the cell or triggers its destruction by immune system process. A relatively new twist on … Continued
A form of immune cell therapy for cancer known as tumor infiltrating lymphocyte, or TIL, therapy, involves removing immune T cells from a piece of the patient’s tumor — where the T cells have succeeded in recognizing the cancer — expanding them outside the body, and re-infusing them by the billions to fight the disease. … Continued
Chris Devin never expected to be diagnosed with multiple myeloma at the age of 45 — and being told he had cancer during the COVID-19 pandemic was far from ideal. But Devin quickly learned that he could rely on his team at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) for the best treatment options. While COVID-19 … Continued
While most lung cancers are linked to tobacco smoking, a minority — about 15 percent in the United States — of non-small cell lung cancers are driven by a random mutation in a gene called EGFR, which helps cells grow and divide. What is EGFR-mutant lung cancer? A mutation in the gene EGFR, which stands … Continued
Researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center are leading a number of studies in osteosarcoma, a type of cancer that starts in the bones.
As head of a family that includes seven children and 12 grandchildren, Susan Voigt says she is used to putting other people first. When it comes to trailblazing multiple myeloma treatment, however, she is proudly out in front. A longtime Vermont resident, Voigt, 69, was the first person from her state to receive CAR T-cell … Continued
CAR T-cell therapy is a form of immunotherapy that uses specially modified T cells – part of the body’s defense system against disease – to attack cancer. As of March 2021, CAR T-cell therapy has been approved by the U.S. Food and Drug Administration as standard therapy for: Some adult patients with aggressive non-Hodgkin lymphoma that has … Continued
CAR T-cell therapy—a form of immunotherapy that uses genetically engineered T cells to intensify the immune system’s response to cancer—represents one of the biggest advances against cancer in recent years.
CAR T-cell therapy is a kind of cellular therapy, which uses a patient’s own immune system cells to rally an attack on cancer. They’re made by removing a specific set of cells from the blood, modifying them in a lab to intensify the immune system’s natural response to cancer, and re-injecting them into the patient. … Continued
Richter’s syndrome involves the rapid transformation of chronic lymphocytic leukemia (CLL) into a significantly more aggressive form of lymphoma, usually diffuse large B-cell lymphoma (DLBCL), but occasionally Hodgkin lymphoma (HL). It arises in 2-10% of all patients with CLL and can occur at any time in the course of the disease. The goal of treatment … Continued
Discovering new cancer treatment can sometimes be a matter of connecting the dots between new pathways and old drugs. That was the case in a new paper in the TKTK issue of Clinical Cancer Research co-authored by Kent Mouw MD, PhD, co-director of Dana-Farber’s Bladder Cancer Center. Mouw and his team found a promising way … Continued
New England may be known for its harsh weather, but it’s never stopped Kyle Vinson from getting out and doing what he loves. An avid skier and golfer, the Massachusetts resident prides himself on once doing both in the same day. When he was diagnosed with metastatic colon cancer in 2020, the 38-year-old had to … Continued
Harold J. Burstein, MD, PhD, physician-scientist in the Breast Oncology Program of the Susan F. Smith Center for Women’s Cancers, provided an update on treatment of ER-positive breast cancer, including the roles of chemotherapy, targeted therapy, and ovarian suppression, in a recent New England Journal of Medicine article. What is ER-positive breast cancer? Of the … Continued
Indolent lymphomas are types of non-Hodgkin lymphoma (NHL) that grow and spread slowly. They account for about 40% of all NHL cases in the United States and generally arise later in life. Treatment for indolent lymphomas depends on a variety of factors, including the type and stage of the disease (how far it has advanced). … Continued
Fionn Mulrooney, a cheerful 11-month-old, in Plymouth, Massachusetts, has no idea he has a life-threatening genetic disease. Nor does he seem fazed by the daily subcutaneous injections his parents have learned how to give him. And little does he know that cells from his bone marrow are helping scientists develop an innovative gene-editing approach that … Continued
Stephanie Davis is a master adapter. When she was initially diagnosed with serous uterine cancer, she found a way to continue working around surgery, radiation, and chemotherapy. Today, she is still adapting — moving from one treatment plan to another as her cancer changes — and is in consultation with her care team to keep … Continued
Chuck Stravin carries a white three-ring binder to all of his oncology appointments. Inside are his appointment notes, information about his treatment history, and the latest research and advancements regarding his disease. Nestled alongside these documents also sits a family photo of Stravin, his wife Liz, and their four daughters. Stravin’s family has been instrumental … Continued
When Samantha Price’s four-year-old daughter, Shelby, was diagnosed with acute lymphoblastic leukemia (T-ALL) in October 2019, Price had so many questions about what the future held for both of them. What would the highs and lows of treatment look and feel like for Shelby, and how could she best care for her daughter throughout the … Continued
