Researchers Use CRISPR To Build A Human Melanoma Model From Scratch

Over the last two decades, researchers have discovered thousands of genetic mutations in cancer. But understanding how they affect the growth and spread of tumors in the body remains challenging because each patient’s tumor can have many different mutations.  Now, scientists have used the CRISPR-Cas9 gene-editing system to build cell models of melanoma “from scratch,” … Read more

What is Cardiac Angiosarcoma?

One of the rarest of rare cancers, cardiac angiosarcoma is a tumor of the heart that has gained some notoriety because it caused the death of fashion designer Virgil Abloh in 2021 at the age of only 41. Abloh, the artistic director of Louis Vuitton menswear and the founder of his own brand, Off-White, lived … Read more

Newly Identified Regulator in Prostate Cancer Cells Could Serve as Drug Target for Advanced Tumors

Treating advanced prostate cancer typically involves surgery — to reduce levels of testosterone, which fuels the growth of tumors — or giving drugs that blockade the androgen receptor (AR), which responds to testosterone by stimulating cancer-growth genes. While these measures can keep the disease at bay initially, resistance almost always occurs as the androgen receptor … Read more

Earlier Use of CAR T-Cell Therapy Approved for Relapsed Large B-cell Lymphoma Patients

Patients with large B-cell lymphoma (LBCL) who did not respond to initial treatment or relapsed within a year may now receive the CAR T-cell product axicabtagene ciloleucel (Yescarta) as a second-line therapy, following approval by the U.S. Food and Drug Administration (FDA) based on results of a recent clinical trial. Until now, the standard of … Read more

Seeking Stem Cell Transplant, Basketball Expert Makes Slam Dunk Decision

As an economist specializing in statistical analysis, Dan Rosenbaum has done everything from help the federal government use more evidence in its decision-making to assist several National Basketball Association (NBA) teams in finding and signing the best players. Research and number-crunching are his expertise, so when Rosenbaum learned he needed a life-saving stem cell transplant … Read more

What is a Stereotactic Breast Biopsy?

An annual physical or mammogram can help detect lumps or abnormalities in the breast, but these exams cannot tell whether a growth is cancerous or noncancerous. If a breast lump or abnormality is found in your breast, your doctor may advise you to have a breast biopsy. A stereotactic breast biopsy is a kind of … Read more

Experts Tackle Relationship Between Environmental Chemicals, Pollution, and Cancer

Many healthy people are concerned about potential risks from exposures to air and water pollution, household chemicals, pesticides, and substances in the workplace. And for cancer patients, it can raise even more anxiety, with people wondering whether something in their environment triggered their disease. However, links between environmental exposures and cancer have been difficult to … Read more

Narjust Duma, MD: Forging a Path for Underrepresented Communities in Medicine

The connection between a researcher’s biography and area of study is not always obvious. A young scientist may discover an intellectual fascination with immunology, for example, despite not having known anyone with an immunological disorder. For Dana-Farber’s Narjust Duma, MD, however, research is not just a response to her life experiences. It’s a way to … Read more

Blood Donation and COVID-19: What You Need to Know

At Dana-Farber Brigham Cancer Center, your health and safety, along with the health and safety of our staff, are our top priorities. The Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and Women’s Hospital is continuing to accept blood and platelet donors in a safe and controlled environment.  Can I donate blood … Read more

Researchers Urge Efforts to Improve Diagnosis and Care of Patients with Disabilities that Affect Mobility

People with disabilities that affect their mobility often face special challenges when diagnosed with cancer. Beyond logistical matters such as getting to and from medical appointments, they may be diagnosed with more advanced, harder-to-treat cancer than non-disabled individuals, making them more likely to die of their disease, research suggests. While most previous studies of these … Read more