Like all vaccines, prostate cancer vaccines work by stimulating the body’s immune system. Unlike vaccines for the flu, COVID-19 and other infections, which protect against disease, prostate cancer vaccines are a form of treatment. Treatment vaccines activate the immune response against cancer cells by targeting antigens – cancer-related proteins produced in greater abundance in tumor … Read more
When breast cancer metastasizes, it often heads for the brain, where it can be exceptionally difficult to root out. The key to preventing the spread of the cancer, or thwarting it if it does reach the brain, is to understand the mechanism that turns stationary tumor cells into nomadic intruders. In a recent study, a … Read more
A white patient looking for a stem cell donor has about a 75% chance of finding a fully-matched unrelated donor in the U.S. NMDP Registry. A fully matched donor has the same human leukocyte antigen (HLA) type, a set of eight genetic variables that dictate how the immune system communicates. Finding a fully matched donor … Read more
Kathy Giusti was driving in rush hour traffic one January day in 1996 when her doctor called and requested they meet the next morning about her recent blood tests. Alarmed, Giusti insisted on more details, and the doctor eventually shared his concerns that she may have multiple myeloma. Giusti’s response to this news was quick … Read more
In the past 25 years, cases of lung cancer have been rising among people without previous tobacco use. These cancer cases are approximately 2.5 times more likely to be found in women than in men. These women tend to be younger, and cases are rising more rapidly in people of Asian or Hispanic/Latina descent. “Asian … Read more
Jim Omel, MD, helped many cancer patients during his long career as a family physician, and that has not changed since his own 1997 diagnosis with multiple myeloma. What has changed is the reach of his support. While Omel, 77, cared for primarily farming families near his Nebraska clinic during 25-plus years in practice, his … Read more
Andrea Baxter remembers talking with girlfriends prior to her first mammogram in February 2023, just four months after her 40th birthday. “We joked about how these routine scans were a sign of getting older,” she recalls. “Nobody thought anything bad would come from them.” From working in the insurance field, Baxter knew that mammograms — … Read more
After treatment for early-stage breast cancer, patients are eager to get back to their normal lives. Most, however, are prescribed five or more years of hormone therapy, such as estrogen-blocking medicines, to help keep the cancer from coming back. These medicines can cause menopause-like symptoms even in people who are decades away from menopause. Symptoms … Read more
When Shirley Joseph met her future husband, Mike Joseph, on the set of one of her music videos in 2021, she had already proven herself as a tenacious entrepreneur. When the COVID-19 pandemic brought the music industry to a halt a year prior and ended talks between Shirley and a major record label, she turned … Read more
As she hopped off the bleachers onto the grass after a graduation ceremony, Elizabeth Zarrella felt an unfamiliar pain in her back. A visit to the emergency room a week later revealed the source of the pain and the reason for its severity: her vertebrae were so brittle that two of them had been compressed … Read more
Small cell lung cancer broadly consists of four molecular subtypes, three of which are driven by expression of proteins called transcription factors. Targeting these transcription factors has been a long-held goal, yet currently there are no medicines that target them directly. Rather, patients today receive standard-of-care treatment consisting of chemotherapy and immunotherapy. Within a year, … Read more
Multiple myeloma is a cancer of the bone marrow. It affects plasma cells, which are mature forms of blood cells called B-lymphocytes. In the case of multiple myeloma, abnormal plasma cells build up in the bone marrow, and can cause anemia. In addition, multiple myeloma may cause kidney problems, bone injury and fractures. There have … Read more
In trial after clinical trial, metastatic colorectal cancer has been largely undeterred by immune checkpoint inhibitors. Although these drugs have shown effectiveness in Hodgkin lymphoma, lung cancer, bladder cancer, kidney cancer, and nearly a dozen other malignancies, their track record against colorectal cancer has been lackluster, particularly for patients with the most common subtype of … Read more
The first time Jay Reese was diagnosed with colon cancer, he didn’t tell his preschool-aged children. After it came back decades later, he told them immediately — and then suggested they take action. Jay underwent genetic testing after his 2012 colon cancer recurrence which revealed he had Lynch syndrome, an inherited genetic condition which carries … Read more
In Zhejiang Province, China, Yijia Wang headed to his local physician to find out the source of a lower back pain that had bothered him for weeks. Results from a biopsy took several weeks, eventually revealing a diagnosis of collecting duct carcinoma, a rare cancer in the kidney. Wang’s first round of treatment with a … Read more
Physician-scientist Franziska Wachter, MD, came to Dana-Farber 10 years ago as a postdoctoral fellow with a vision. In the clinic, she cares for children with hard-to-treat cases of acute myeloid leukemia (AML). In the laboratory, her eyes are on the molecular drivers of the disease. “I try to connect the two roles as much as … Read more
While hematological cancers like leukemia, lymphoma, and multiple myeloma involve white blood cells, other, rarer hematologic malignancies affect red blood cells and platelets. These include polycythemia vera, in which the bone marrow produces too many red blood cells, and essential thrombocythemia, in which platelets levels are abnormally high. Both are chronic diseases that can usually … Read more
There are ways to make connections even as you are navigating such a challenging time.
Physician-scientist Franziska Wachter, MD, came to Dana-Farber 10 years ago as a postdoctoral fellow with a vision. In the clinic, she cares for children with hard-to-treat cases of acute myeloid leukemia (AML). In the laboratory, her eyes are on the molecular drivers of the disease.
Bladder cancer treatment is advancing, with several approved immunotherapy options, an approved gene therapy, and an approach to cell therapy planned for testing in clinical trials at Dana-Farber. What is bladder cancer? The most common form of bladder cancer is urothelial carcinoma, in which the urothelial cells that line the bladder and urinary tract begin … Read more