Thoracic Cancer

Three Recent Dana-Farber Research Studies to Know About  

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Every year, physician researchers at Dana-Farber Cancer Institute reveal new treatments, protocols, and outcomes that advance cancer research. At one of this year’s biggest cancer research conferences, the European Society for Medical Oncology (ESMO) Congress in Berlin, Germany, Dana-Farber researchers presented 22 studies in breast, lung, and bladder cancer.  Here are three of the most exciting advancements — several nearing U.S. Food and Drug Administration (FDA) approval — shared by our experts nearly 4,000 miles across the world.  An oral therapy for advanced breast cancer   Erica Mayer, MD, MPH, director … Read more

TILs: What Are They and How Are They Used in Cancer Treatment?

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What is TIL (tumor-infiltrating lymphocyte) therapy? Tumor-infiltrating lymphocyte, or TIL, therapy uses a patient’s own immune system T cells to fight cancer. The therapy involves removing T cells from a piece of the patient’s tumor – where the T cells have congregated after being alerted to the cancer – growing them outside the body, then … Read more

Microplastics and Cancer: Your Questions Answered 

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In recent decades, rates of some cancers, such as colorectal cancer, have been rising in young adults under the age of 50. One possible explanation for this rise is a parallel rise in obesity rates and changes in diet, activity levels and lifestyle.   However, says Kimmie Ng, MD, MPH, director of Dana-Farber’s Young-Onset Colorectal Cancer … Read more

Lung Cancer Cases Rising in Young Women of Asian and Latina Descent: What You Need to Know 

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In the past 25 years, cases of lung cancer have been rising among people without previous tobacco use. These cancer cases are approximately 2.5 times more likely to be found in women than in men. These women tend to be younger, and cases are rising more rapidly in people of Asian or Hispanic/Latina descent.  “Asian … Read more

Study Uncovers Potential Targeted Therapy for Small Cell Lung Cancer 

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Small cell lung cancer broadly consists of four molecular subtypes, three of which are driven by expression of proteins called transcription factors. Targeting these transcription factors has been a long-held goal, yet currently there are no medicines that target them directly.   Rather, patients today receive standard-of-care treatment consisting of chemotherapy and immunotherapy. Within a year, … Read more

What Are The Types of Lung Cancer? 

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There are several types of lung cancer. On a basic level, lung cancers fall into two main subtypes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC).  Just as each person is unique, every lung cancer is unique. At Dana-Farber’s Lowe Center for Thoracic (Lung) Cancer Treatment Center, oncologists work with a team … Read more

Multitude of Mutations Spells Susceptibility to Immunotherapy

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Non-small cell lung cancers (NSCLCs) that are most loaded with genetic mutations are most susceptible to immunotherapy drugs known as PD-L1 inhibitors, a new study by Dana-Farber researchers shows. The study, published recently in JAMA Oncology, can help doctors identify patients with the disease who are likely to benefit from the drugs, which foil tumors’ … Read more

Study Points to Link Between Genetic Ancestry and Genetic Signature of Lung Cancer

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Even as science has removed all doubt about the link between environmental factors like tobacco smoke and lung cancer, the role of genetics in people’s risk of the disease has been much harder to pin down. A study by Dana-Farber investigators provides new evidence that, in people with lung cancer, genetic ancestry can influence the … Read more

Advances in Myeloma, Breast Cancer, and Clinical Trials Equity: A Dana-Farber Research Update

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Results of several phase 3 trials and dozens of other studies led by Dana-Farber researchers were presented online and in person June 3-7 at the 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO), the world’s largest clinical cancer research meeting. Some of the research reports presented by Dana-Farber investigators include: Improved progression-free … Read more

Patient with Lung Cancer Participates in ‘Practice-Changing’ Immunotherapy Research

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Every school day, when Mike James walks into work at Boston Adult Technical Academy (BATA), he sees an inspiring sign painted by the students: Together, We Can. That philosophy lifted James up after he was diagnosed with early-stage non-small cell lung cancer in August 2019. James leaned on his support network of coworkers, his family, … Read more

Narjust Duma, MD: Forging a Path for Underrepresented Communities in Medicine

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The connection between a researcher’s biography and area of study is not always obvious. A young scientist may discover an intellectual fascination with immunology, for example, despite not having known anyone with an immunological disorder. For Dana-Farber’s Narjust Duma, MD, however, research is not just a response to her life experiences. It’s a way to … Read more

Mother of Three in Remission from Stage IV Lung Cancer after Immunotherapy

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In December 2013, Michelle Leonard wasn’t too concerned when she felt a pain in her right chest. “I kind of thought, ‘Well at least it’s the right side, not a big deal,’” she says. But then she developed a fever and decided to go to her primary care physician. Her nurse practitioner sent her for … Read more

Tips for How Cancer Patients Can Quit Smoking

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Quitting smoking during cancer treatment may seem overwhelming, but this is an especially important time to try. Active cancer patients and survivors who cut down on their cigarettes, vaping, or other nicotine use can experience a reduction in heart, stomach, and infection problems related to chemotherapy toxicity, improve their healing and breathing post-surgery, and decrease … Read more

Lung Cancer Patient Draws on Unwavering Strength in the Face of Uncertainty

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When looking for inspiration, Saila Hanninen needs only to glance at her left wrist. Tattooed there is the Finnish word “jaksaa” (pronounced YÄK SAH), roughly translating to “strength.” Jaksaa, however, is about more than just physical strength: It’s about fortitude, endurance, mental toughness, and a willingness to keep going when the odds are against you. … Read more