How are Genes Involved in Cancer?

Genes don’t cause cancer, but genetic mutations can. Our cells have about 22,000 genes, which consist of DNA packed into chromosomes inside the cell nucleus. These genes control a wide range of functions, including cell growth and division. When the genes misbehave or mutate, cancer can develop. Sometimes these mutations are inherited. In that case, … Read more

Meningioma: A tumor on the edge of the brain

Musician Sheryl Crow announced on June 5 that she has a benign brain tumor known as a meningioma. Below, doctors from Dana-Farber’s Center for Neuro-Oncology describe this condition. The singer-songwriter, a breast cancer survivor, visited Dana-Farber in 2006.

Meningiomas are tumors on the surface of the brain, spinal cord, and fluid spaces. They are the most common type of brain tumor, with approximately 55,000 new cases diagnosed annually in the United States.

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New developments in brain tumor treatment: Five questions for David Reardon, MD

More than 600,000 people in the United States are living with a primary brain tumor — one that begins and stays in the brain — and over 60,000 adults and children will be diagnosed with a brain tumor this year.

In recognition of May as Brain Tumor Awareness Month, we asked David Reardon, MD, clinical director of the Center for Neuro-Oncology at Dana-Farber/Brigham and Women’s Cancer Center, for the latest advances in brain tumor research and patient care.

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Pregnancy and breast cancer: One mother’s story

Rebecca Byrne had waited years for a doctor to tell her, “You’re pregnant.” She never imagined that just a few months after she first heard those words, she would hear four more: “You have breast cancer.”

Byrne still tears up when telling the story, but smiles when her 20-month-old daughter, Emelia, leaps into her lap. Emelia is the happy outcome of a painful period of Byrne’s life, when the joys of pending and early motherhood were shadowed by chemotherapy treatments, hair loss, radiation, and uncertainty.

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Prostate cancer: At what age should you be screened?

What age is appropriate to get screened for prostate cancer and begin treatment? Recent news surrounding Warren Buffett’s diagnosis, including a report on Boston.com, has some asking if age should factor into these decisions. Dr. Philip Kantoff, chief of the Division of Solid tumor at Dana-Farber and director of Dana-Farber’s Lank Center for Genitourinary Oncology, speaks … Read more

Alcohol and breast cancer: What’s the risk?

For many women who enjoy a glass of wine, research showing that relatively small amounts of alcohol can raise their risk of breast cancer are disconcerting, to say the least. And confusing, too.

How much drinking is OK? Isn’t a glass of red wine a day good for your heart — and couldn’t that be more important?

In the past five or 10 years, knowledge about alcohol and breast cancer has been changing as studies produce new results and are publicized, sometimes over-dramatically, in the media. At the same time, there’s growing evidence that moderate drinking can be healthy for the heart.

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Genetic counseling now recommended for children with sarcoma

If your son or daughter has been diagnosed with a type of sarcoma – a tumor in connective tissue like muscles or bones – there are many questions: Will my child make a full recovery? What are the immediate and long-term side effects of treatment?

Most parents don’t consider whether their child will face a second cancer later in life.

However, a link between sarcomas and Li-Fraumeni syndrome, a rare condition that raises a person’s risk of developing one or more cancers to as high as 85 percent, has led genetic specialists at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center to recommend that all child sarcoma patients be offered genetic counseling for Li-Fraumeni syndrome. 

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HPV linked to head and neck cancer

Traditionally, patients with oral cancers tended to be older individuals with a long history of smoking and heavy alcohol use. In the past decade, however, that picture has changed dramatically.

Today, infection with the human papillomavirus (HPV) is the leading cause of oropharyngeal cancer in the U.S. and Western Europe. Oropharyngeal cancers affect the back of the throat (i.e. the tonsils and base of the tongue). HPV is the same virus that causes most cases of cervical cancer in women.

Patients with HPV-related head and neck cancers are often relatively young, not heavy drinkers or smokers, and come from all segments of society.

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Blood cancer research may lead to new treatments

At this year’s American Society of Hematology Annual Meeting, Dana-Farber scientists presented major findings that could one day improve diagnosis and treatment of blood cancers, extend life, or even cure some diseases. Among the highlights: Steven Treon, MD, PhD, and his colleagues identified a gene mutation that underlies the vast majority of cases of Waldenström’s … Read more

Breast cancer specialist discusses treatment advances

Harold J. Burstein, MD, PhD, a Dana-Farber breast cancer specialist, discusses some of the important studies presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. The five-day meeting includes more than 1,000 scientific presentations, seminars, and posters, with a focus on emerging treatments in hard-to-treat populations, patients with metastatic breast cancer, and breast cancer … Read more