Clinical trials are scientific studies in which new treatments — drugs, diagnostic procedures, and other therapies — are tested in people to find out if they are safe and effective. Nearly all cancer drugs in use today were tested in clinical trials. If you have been diagnosed with cancer, the benefits of participating in a clinical … Read more
When researchers report the survival effect of a cancer drug in a clinical trial, they almost always use a measure called hazard ratio. For all its ubiquity, however, hazard ratio has a hazard of its own: it’s a bit tricky to understand. A 2019 study found that 47% of researchers misinterpreted hazard ratio (HR) when … Read more
With its deep experience in studying the rare, often lethal cancer known as NUT carcinoma, Dana-Farber Brigham Cancer Center attracts patients and families, some from far away. Unfortunately, NUT carcinoma is so rapidly aggressive that “sometimes patients get to Dana-Farber and become too sick to proceed with treatment,” which speaks to the urgent need for … Read more
Results of several phase 3 trials and dozens of other studies led by Dana-Farber researchers were presented online and in person June 3-7 at the 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO), the world’s largest clinical cancer research meeting. Some of the research reports presented by Dana-Farber investigators include: Improved progression-free … Read more
Clinical trials are research studies that test new therapies or existing treatments to better understand their safety and efficacy. Every treatment that is now approved by the U.S. Food and Drug Administration (FDA) was tested in a clinical trial involving patients who volunteer, usually after a discussion with their physician. The clinical trial system is … Read more
Medically reviewed by David M. Weinstock, MD, and Eric Jacobsen, MD By banding together to study the basic biology and vulnerabilities of T-cell lymphoma, scientists at several major cancer research centers have sparked a surge of clinical trials of promising treatments for the disease. The string of new trials, some already open, some expected to … Read more
Dana-Farber’s Geoffrey Shapiro, MD, PhD, answers common questions about clinical trials and how they help improve cancer treatment.
Researchers are applying the knowledge they’ve gained in previous clinical trials as they look into how immunotherapy might provide additional treatment options for patients with recurrent cervical cancer.
Each time the metastatic breast cancer spreads too deeply into Sayde Patel’s lungs, she changes clinical trials. And after six switches in 10 years, she maintains a glass-half-full attitude about the process.
Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested to determine if they are safe and effective for patients. Nearly all cancer drugs in use today were tested and made available to patients through clinical trials, making them a crucial component of cancer research. But what does … Read more
When a clinical trial shows that a new treatment is no better than the standard, it can be disappointing. But such outcomes yield valuable, potentially lifesaving information. Trials can “fail” if the experimental therapy doesn’t work better than current treatments. These “negative” outcomes are important for several reasons. They can spare patients false hope or … Read more
Better cancer treatments depend on clinical trials of new drugs and other therapies, but in the United States, only 3 percent of cancer patients participate in these investigations of new therapies. Patients often hesitate to participate because they don’t understand the process or have misconceptions about what it means for them. “There’s a national lack … Read more
Cancers of the vulva – the external portion of the female genitals – are diagnosed in approximately 4,700 women in the United States each year. While many patients can be cured by a combination of surgery, chemotherapy, and radiation therapy, others – particularly those whose cancer has metastasized to other parts of the body – … Read more
Current lymphoma therapies are a far cry from the mustard gas used more than 50 years ago. More treatment options, including ones that may be more effective and less toxic, are being studied in ongoing clinical trials. “Clinical trials really are the future of lymphoma treatment,” says Ann LaCasce, MD, a medical oncologist in the … Read more
By Ian Krop, MD, PhD Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested in people to find out if they are safe and effective. Nearly all cancer drugs in use today were tested in clinical trials.
While some racial and ethnic groups have been underrepresented in clinical trials of therapies for lung cancer, breast cancer and other malignancies, researchers speculated that the situation might be different for adult leukemia trials. The unique features of the disease — the speed with which it needs to be treated after diagnosis, the delivery of … Read more
As head of marketing for a leading international news agency, Kelly Ives routinely worked with journalists across the globe. When it came to chronic lymphocytic leukemia (CLL), however, it was her own reporting skills that led Ives to a life-changing treatment. Ives was a 37-year-old mom with a career and three young children, including an … Read more
The majority of women diagnosed with breast cancer have early-stage disease that is confined to the breast or nearby lymph nodes and is effectively treated by lumpectomy or mastectomy. Nevertheless, small clusters of cancer cells remaining after surgery — called micrometastases — have the potential to spread at some point and cause a cancer recurrence, … Read more
Just as the COVID-19 pandemic was sending entire states into lockdown, Jill Bailey learned that her metastatic cervical cancer was beginning to break free of the grip of chemotherapy. It was March 2020. Scans showed that Bailey’s metastatic tumors, which had shrunk in response to chemotherapy and another drug, were slowly starting to grow. A … Read more
Carol Brown, 80, has been through quite a turbulent 2020. Her much-beloved pastimes, including playing violin in a senior orchestra, book groups, and weekly church services, are now virtual due to the COVID-19 pandemic. The Boston-area resident had to cancel a March trip to visit family out west, and she spent the summer packing up … Read more