BreastCancer

Dr. Jay Harris discusses the link between radiation therapy for breast cancer and heart disease

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By Robert Levy

In a recent study, Oxford University researchers reported that although radiation therapy is a critical tool for the treatment of women with breast cancer, it can also raise their risk of a heart attack or heart disease later in life. The study was based on a review of medical records of 2,168 women in Sweden and Denmark who received radiation therapy for breast cancer between 1958 and 2001, and who were under age 70 at the time.

News coverage of the study, published in the New England Journal of Medicine, has drawn new attention to the heart risks associated with radiation therapy even as it underscores such therapy’s role in improving survival rates for breast cancer patients.

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What Happens If You’re Allergic to Your Chemo Drugs?

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Before Oct. 31, 2012, I would have probably guessed that desensitization was a process invented by mental health professionals to make really sensitive people less sensitive. I might have inquired about the cost to put my four-year-old son through “desensitization” so that he wouldn’t throw such a fit when he lost a game of knee hockey in our basement.

Now I know that desensitization is a life-saving process necessary to treat cancer patients like me.

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Do BRCA Mutations Increase a Woman’s Lifetime Cancer Risk?

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By Judy Garber, MD, MPH

We know that women who inherit harmful mutations in the genes BRCA1 or BRCA2 have a sharply increased risk of developing breast and/or ovarian cancer at an early age (prior to menopause). In fact, women with inherited BRCA1 or 2 mutations are about five times more likely to develop breast cancer — and at least 10 times more likely to develop ovarian cancer — than women without such mutations, according to the National Cancer Institute.

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Managing Cancer Risk: Miss America Contestant’s Decision Puts Genetics and Cancer Center Stage

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Win or lose, Miss America contestant Allyn Rose made news with her decision to undergo a double mastectomy. According to the Associated Press, Rose, who lost her mother to breast cancer, inherited a rare genetic mutation which might put her at greater risk for developing cancer.

Her decision to have the preventive surgery has sparked questions about genetics, cancer risk and strategies for preventing cancer.

If you have a question about genetic factors that increase cancer risk, you can ask the Dana-Farber cancer genetics team.

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Can Breast Cancer Patients Avoid Multiple Surgeries?

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When Jane Davis was diagnosed with breast cancer last July, she began learning as much as she could about her disease. Davis quickly discovered one of the most startling statistics about breast cancer: Up to 40 percent of women who have a lumpectomy require a second surgery. That’s because surgeons often cannot microscopically remove the entire tumor.

But Mehra Golshan, MD, FACS, director of Breast Surgical Services at Dana-Farber/Brigham and Women’s Cancer Center, is trying to change that with a phase I breast surgery pilot study. It’s the first of its kind in the world.

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Does Breast Density Affect Mammogram Results?

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While there are genetic and lifestyle risks for breast cancer, some may not realize that breast density also plays a significant role in risk for the disease.  Breasts are considered dense if they are mostly made up of glandular and fibrous tissue and not much fat. Breast density can be seen only on a mammogram; the firmness of breasts is … Read more

When a Celebrity Has Breast Cancer

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by Erica Mayer, MD, MPH 

In 1974, when First Lady Betty Ford announced that she had undergone a mastectomy for breast cancer, it was a turning point in people’s willingness to talk about the disease. Prior to that, discussing cancer of any type, even with one’s family or friends, was often taboo. The First Lady’s openness about her cancer helped create a space in which women felt more comfortable talking about their experience – and about being screened for the disease.

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Breast Cancer, Aromatase Inhibitors, and Bone Density

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Aromatase inhibitors (AIs), such as Arimidex, Aromasin, and Femara, have proven to be more effective than previous hormonal treatments for treating both early and advanced breast cancer in post-menopausal women whose tumors are dependent on estrogen. Compared with tamoxifen, these drugs are less likely to cause blood clots or raise the risk of endometrial cancer. As a result, AIs are used both in patients with early breast cancer and in those with metastatic disease.

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How to Build a Support Network

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By Lola Baltzell

People often ask me: How do you manage to live with metastatic breast cancer? One of the most important strategies for me has been building a support network.

My diagnosis of breast cancer that had already spread to my bones came out of the blue. I had a normal mammogram 13 months earlier, and no known risk factors. So when I heard the news in August 2008, my first impulse was to reach out for support.

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How are Genes Involved in Cancer?

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Genes don’t cause cancer, but genetic mutations can. Our cells have about 22,000 genes, which consist of DNA packed into chromosomes inside the cell nucleus. These genes control a wide range of functions, including cell growth and division. When the genes misbehave or mutate, cancer can develop. Sometimes these mutations are inherited. In that case, … Read more

Meningioma: A tumor on the edge of the brain

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Musician Sheryl Crow announced on June 5 that she has a benign brain tumor known as a meningioma. Below, doctors from Dana-Farber’s Center for Neuro-Oncology describe this condition. The singer-songwriter, a breast cancer survivor, visited Dana-Farber in 2006.

Meningiomas are tumors on the surface of the brain, spinal cord, and fluid spaces. They are the most common type of brain tumor, with approximately 55,000 new cases diagnosed annually in the United States.

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Five reasons to be optimistic about the future of cancer treatment

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It’s not always easy to recognize that we live in a golden age. Too often we fail to appreciate the amazing things going on around us because we‘re so caught up in day-to-day activities and pressing demands that we presume that the extraordinary is rather ordinary.

So it may be with cancer treatment in 2012.  And the future looks to be even better – not necessarily easier, simpler, or cheaper, but unequivocally better.

Here are five reasons why.

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