Insights from decades of cancer research are surprisingly transferable to the battle against COVID-19. The desire to save life and ease suffering that motivates cancer researchers has been directed to the new disease as well. Drawing on their knowledge of cancer drug mechanisms, and of the adverse side effects of some of those drugs, Dana-Farber … Read more
The resilience shown by cancer care providers during the coronavirus crisis is in equal supply among those involved in clinical research. The strict protocols associated with these studies — rules on eligibility, consent, criteria for tracking response, data collection and analysis — might seem to allow little of the flexibility needed in the COVID-19 era. … Read more
Dana-Farber scientists recently uncovered a potential vulnerability in a form of ovarian cancer notoriously resistant to chemotherapy. Now they’ve opened a clinical trial involving a drug that targets that susceptibility in patients with the disease. The impetus for their research is a type of ovarian cancer with excess copies of the cyclinE1 gene (abbreviated CCNE1). … Read more
Clinical trials are research studies that examine whether new therapies, diagnostic techniques, or disease-prevention strategies are safe and effective in people. They’re considered the gold standard for determining if newly developed treatments produce better results and fewer side effects than standard therapies. All proposals for clinical trials go through a rigorous review at the institution … Read more
In recent years, there has been a dearth of clinical trials studying new approaches to how endometrial cancer, which forms in the lining of the uterus, is treated. That is changing rapidly, however, as basic research into the disease spurs the testing of novel drugs and drug combinations. A host of clinical trials—including four led … Read more
Eli Morse has had to make major changes to his active lifestyle, but one thing has stayed the same: Eli and his family will continue to fight his aplastic anemia together.
A clinical trial at Dana-Farber has kept Sharon DeCosta’s stage IV metastatic breast cancer stabilized for three years, allowing her a full life of traveling and doting on her three young grandchildren, with a fourth due in December.
Keith Rohleder was diagnosed with a rare, aggressive blood cancer that most people have never heard of. But a new clinical trial put him into remission.
“Research” is a broad stroke of a word, the verbal equivalent of painting a wall instead of a masterpiece. There are important distinctions among the three principal types of medical research — basic, clinical and translational. Whereas basic research is looking at questions related to how nature works, translational research aims to take what’s learned … Read more
This originally appeared on Vector, Boston Children’s Hospital’s blog. Adrenoleukodystrophy — depicted in the 1992 movie “Lorenzo’s Oil” — is a genetic disease that most severely affects boys. Caused by a defective gene on the X chromosome, it triggers a build-up of fatty acids that damage the protective myelin sheaths of the brain’s neurons, leading to cognitive … Read more
Clinical trials are research studies that explore whether new treatments, diagnostic techniques, or disease-prevention strategies are safe and effective in patients. They may be an option when patients no longer benefit from standard therapies. They may also offer an alternative to standard therapies, particularly if the agent being tested is likely to be more effective … Read more
As researchers and clinicians in the Susan F. Smith Center for Women’s Cancers at Dana-Farber continue studying the benefits of a two-drug combination in slowing progression of recurrent ovarian cancer, one patient is as a beacon of hope for her caregivers – and for others facing the disease. Betsy Brauser, treated with standard chemotherapy near … Read more
Kerri Antonuccio marked her 40th birthday this spring with a fresh lease on life. For the first time since 2012, she didn’t feel too sick from cancer treatment to enjoy her big day. She was also able to travel to Mexico and serve as matron of honor at her sister’s wedding in May, as well … Read more
When facing a diagnosis of metastatic breast cancer, patients often have many questions about clinical trials: Is a clinical trial right for me? When is a good time to consider a clinical trial? What types of treatments might be available? While there may be many questions about the process, the decision to participate in a … Read more
Clinical trials are a key part of medical science’s effort to improve treatments for cancer patients. There are a variety of different types of trials, including therapeutic clinical trials, which test the safety and effectiveness of potential new agents in patients. Some patients participate in several therapeutic clinical trials, in succession, over the course of … Read more
When Elizabeth Cahn was presented with her treatment options for triple-negative breast cancer, the decision was about more than just getting healthy; it was about “paying it forward.” “I know there are many people who participated in clinical trials before I came along and it was because of their participation that researchers were able to … Read more
Nearly all cancer drugs in use today were developed through clinical trials. But before they are approved for use, they must go through multiple phases designed to test the drug’s safety and efficacy. These phases include preclinical, phase I, II, and III. In phase I clinical trials, investigators evaluate how often and how much of … Read more
Findings from clinical trials have increased survival rates significantly in the last several decades for children with germ cell tumors.
Susan Johnson was diagnosed with a rare, slow-growing brain tumor in 1992. More than 25 years later, Susan is living with cancer — thanks to the chemotherapy, radiation, surgery and clinical trials that have kept her tumor at bay.
Dana-Farber researcher Charles Stiles, PhD, remembers the call. It was 2008 and a colleague phoned from a conference to deliver the news. Two separate research teams had discovered a genetic driver for the most common of childhood brain tumors called pediatric low-grade glioma. The problem of finding a genetic target to improve treatment for this … Read more