Although less common than other types of skin cancer, melanoma is a dangerous disease that can spread rapidly if it is not caught early. In addition to regular self exams, it is crucial to protect yourself from the damaging effects of the sun — regardless of your age, skin color, or the time of year. … Read more
This post originally appeared on Vector, Boston Children’s Hospital’s science and clinical innovation blog. It’s long been a mystery why some of our cells can have mutations associated with cancer, yet are not truly cancerous. Now researchers have, for the first time, watched a cancer spread from a single cell in a live animal, and … Read more
Since the early 2000s, when Dana-Farber scientists discovered that many cancer cells carry “checkpoint” proteins that ward off an immune system attack on tumors, a great deal of research has focused on the development and testing of agents capable of blocking those proteins. In many patients, such agents have sent cancers into long-term remissions. A checkpoint … Read more
Former President Jimmy Carter’s announcement earlier this week that he is free of the melanoma that had spread to his liver and brain may be the highest-profile example yet of the promise of a new form of cancer treatment that unleashes an immune system attack on the disease. Carter, 91, was treated with radiation therapy … Read more
Moles are benign growths on the skin that sometimes become cancerous. But what exactly is the connection between moles and melanoma, the most aggressive skin cancer? While it’s true that people with many moles should be screened more frequently by a dermatologist, scientists are learning that the mole-melanoma connection isn’t so straightforward. For example, a … Read more
Just over a month after approving a first-of-its-kind combination therapy for advanced melanoma, the U.S. Food and Drug Administration (FDA) has signed off on another drug combination to treat the disease. The FDA has approved a targeted therapy combination, Cotellic (cobimetinib) and vemurafenib, to treat advanced melanoma that has spread to other parts of the … Read more
This blog post originally appeared on Cancer Research Catalyst, the official blog of the American Association for Cancer Research. By Karen Honey, PhD Last week, new ground was broken in the field of cancer immunotherapy when the U.S. Food and Drug Administration (FDA) approved the first cancer treatment to combine two of these cutting-edge agents: … Read more
By Stacy Kennedy, MPH, RD When it comes to sun safety, lathering on sunscreen, sporting broad-brimmed hats and staying in the shade surely come to mind. But diet and melanoma may also be linked. Here is some information on the emerging research around obesity, antioxidant intake, vitamin D and other potential nutrition-related links to melanoma. … Read more
Sun safety applies to everyone, regardless of skin color, gender, or age. That was the message emphasized in a recent live video webchat with Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) dermatologist Jennifer Lin, MD. During the chat, Lin answered questions about the latest in melanoma treatment and prevention. “The bottom line is that UV radiation … Read more
Medically reviewed by Carlos Rodriguez-Galindo, MD Although melanoma is more commonly found in adults, childhood and adolescent melanoma affects approximately 300 children in the U.S. each year. Thankfully, the incidence rate has started to decrease in recent years. While melanoma is the least common type of skin cancer in adults, skin cancer in children is almost … Read more
The growing excitement about the potential of immunotherapy treatments for cancer continued at the 2015 meeting of the American Association for Cancer Research (AACR), one of the largest cancer research meetings of the year. Several Dana-Farber investigators presented encouraging results of immunotherapy for melanoma, lung cancer, and breast cancer. F. Stephen Hodi, MD, and Leena … Read more
Melanoma, a type of skin cancer, gets its name from the pigment-producing cells called melanocytes from which tumors can develop. Melanocytes manufacture melanin, a substance in your body that produces hair, eye, and skin pigmentation. Melanin absorbs sunlight and helps to protect skin from DNA damaging ultraviolet light which can contribute to the development of … Read more
Melanoma, the most severe form of skin cancer, results from an interaction between the genetics of the individual and damage to DNA from external factors. In the case of melanoma, most of the environmental damage is due to exposure to ultraviolet light from the sun. The cancer develops in the pigment-producing cells of the skin … Read more
“Science and Society” was the theme of this year’s American Society of Clinical Oncology (ASCO) 50th annual meeting. The meeting showcased cancer research from around the world. Some new findings from Dana-Farber researchers included: Joyce Liu, MD, MPH, of the Susan F. Smith Center for Women’s Cancers reported that, in a phase 2 clinical trial, … Read more
Although skin cancer is the most common cancer in the United States, melanoma accounts for less than 2 percent of all skin cancer cases. The disease is the most aggressive form of skin cancer. Melanoma begins in the melanocytes, which are found on the lower part of the epidermis. The disease can occur anywhere on … Read more
It’s well known that excessive sunning and sunburns can foment the development of malignant melanoma, the deadliest skin cancer. Now, in a preliminary study, scientists have suggested that drinking alcohol may be an added risk factor for the disease.
As recently as five years ago, progress in treating life-threatening malignant melanoma was slow. Since then, several molecularly targeted drugs have burst on the scene, and new strategies for awakening the immune system to attack the cancer cells have yielded dramatic long-term survival benefits for some patients. “The outlook for patients has never been so … Read more
“I don’t believe that optimism can cure cancer, but I do believe one’s general health around the edges can make a difference.” Sam Donaldson, ABC News contributor, learned he had melanoma in 1997. Despite his diagnosis, he opted to stay positive and learn all he could about his disease. Now chairman emeritus of the foundation board … Read more
Often caused by excessive exposure to ultraviolet (UV) rays in sunlight, melanoma accounts for only 4 to 5 percent of skin cancer cases, but is responsible for most skin cancer-related deaths. As with many forms of cancer, melanoma is often misunderstood, and myths persist. When detected and treated in its earliest stages, however, melanoma is often … Read more
Dana-Farber researcher Charles Stiles, PhD, remembers the call. It was 2008 and a colleague phoned from a conference to deliver the news. Two separate research teams had discovered a genetic driver for the most common of childhood brain tumors called pediatric low-grade glioma. The problem of finding a genetic target to improve treatment for this … Read more