On a sunny July afternoon, Michelle Lemieux ran onto the field at Fenway Park to throw out the ceremonial first pitch during a Boston Red Sox home game. While the crowd of over 36,000 people continued to applaud as Lemieux ran back to her family, only a handful in attendance could truly appreciate what she … Read more
At just 14 years old, Kaitlyn Vu was asked to accept a drastic, life-altering surgery. In early 2019, she was diagnosed with osteosarcoma — a rare type of bone cancer that ultimately led to the amputation of her left foot. Kaitlyn’s ability to meet each challenge of her diagnosis with a combination of grace and … Read more
Human papillomavirus (HPV) is a virus that can cause abnormal tissue growth and other changes to cells. It can be spread through skin-to-skin contact during sexual activity, and it can be carried by all sexes. There are over 100 different types (or strains) of the virus, which are considered either “low-risk” (because they cause warts) … Read more
William G. Kaelin, Jr., MD, of Dana-Farber Cancer Institute, won a Nobel Prize in Medicine on Oct. 7 for deciphering the mechanism that enables cells to sense and adapt to changes in oxygen abundance. Kaelin participated in a live Q&A with Stat on Oct. 17. Below are highlights. What are the most important applications of … Read more
It lacks sunsets and skylines, but Maddie Carlson loves the view from her dorm room at Emmanuel College in Boston. If the 20-year-old junior sticks her head out the window at just the right angle, she can almost make out a portion of the place she credits for saving her life after she was diagnosed … Read more
It’s easy to spot Richard “Dick” Welchons’s car in the parking lot: the 90-year old drives a 2016 bright yellow Camaro, his third version of the high-powered muscle car. He has no plan to give it up any time soon — especially after doctors spotted something suspicious on his left foot in 2014, momentarily forcing … Read more
This post was originally published on Discoveries, the blog of Boston Children’s Hospital. Jake was diagnosed with his first cancer — osteosarcoma — in 2007 when he was only 16 years old. Meanwhile, his mom was being treated for recurrent cancer and his brother also would soon be diagnosed with cancer. Within the space of a few … Read more
There was always a good chance William G. Kaelin Jr., MD, and two other scientists working on the same problem would share a Nobel Prize, as they did on Oct. 7, for deciphering the mechanism that enables cells to sense and adapt to changes in oxygen abundance. The three had already been honored with two major awards … Read more
Medically reviewed by Timothy Rebbeck, PhD Lawn care can help grass become and stay full, green, and healthy, but are the chemicals and fertilizers that you use to take care of your lawn increasing your cancer risk? Fertilizers, herbicides, and pesticides are common lawn care products. Although frequent exposure to chemicals in these products can … Read more
Medically reviewed by Jennifer A. Ligibel, MD There may be more advantages to being a morning person than waking up bright-eyed and eager to take on the day. In a recent study involving nearly 400,000 women, British researchers found evidence that a preference for mornings was associated with a slight reduction in breast cancer risk. … Read more
By Amanda DeGiorgi Menopause, arthritis, wigs, medical bills, less sex, no sex… sounds more like a retiree’s worst nightmare than my reality as a 29-year-old about to be married. But life rarely goes as planned, and it can take you on a wild ride when you’re least expecting it. Now that surgery, chemotherapy, radiation, and … Read more
Medically reviewed by Jun Qi, PhD Cancer is extremely clever at finding ways to survive, so even the most successful new drugs tend to become less effective over time as the tumors develop resistance. Often, cancer cells become resistant because of changes in the cells’ genetic code, allowing them to counteract or sidestep the drugs’ … Read more
JUUL is a brand of electronic cigarette, or e-cigarette, that enables users to inhale vapor infused with nicotine, flavorings, and other compounds. How does the JUUL work? JUULs consist of a battery-powered vaporizer that connects to a cartridge, or “pod,” filled with liquid containing nicotine salts, flavorings, and other substances such as glycerol, propylene glycol, … Read more
A mutation is a change in the sequence of DNA units, which are like the letters of the alphabet, that make up the genetic instructions that determine a cell’s structure and function. A mutation in a gene could be compared to a simple misspelling of a word by a single letter, or a duplication or … Read more
Family is the most important part of Michelle Nagel’s life. When she was diagnosed with acute myeloid leukemia (AML) in May 2007, her mind instantly went to her children; all she wanted was to see them grow up and have children of their own. When she learned of her condition, Nagel and her family … Read more
Medically reviewed by Andrew Lane, MD, PhD Dana-Farber scientists had a perfectly reasonable theory of why acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) sometimes become resistant to the targeted drug tagraxofusp. Cancer, however, can flout even the best theories. An account of the discovery of the true source of resistance to … Read more
Dana-Farber scientists recently uncovered a potential vulnerability in a form of ovarian cancer notoriously resistant to chemotherapy. Now they’ve opened a clinical trial involving a drug that targets that susceptibility in patients with the disease. The impetus for their research is a type of ovarian cancer with excess copies of the cyclinE1 gene (abbreviated CCNE1). … Read more
Since it was approved by the U.S. Food and Drug Administration (FDA) in the fall of 2017, a form of the powerful and promising therapy known as CAR T-cell therapy has been used to treat certain young patients with B-cell acute lymphoblastic leukemia (ALL) who have relapsed or didn’t respond to standard regimens. Today, researchers … Read more
When he was 67 years old, Barry Polsky said “I do” for the first time in his life when he married his wife, Randi. One year later, the retired high school teacher and lifelong baseball fan was offered one of his dream jobs as a tour guide at Fenway Park. And earlier this year, at … Read more
Per- and polyfluoroalkyl substances (PFASs) are chemicals whose ability to repel oil and water has led them to be used in a wide variety of consumer products, such as non-stick cookware, water-repellent clothing, stain-resistant fabrics and carpets, some cosmetics, and food containers that resist grease and oil. They’re highly stable chemicals, so they can persist … Read more