Richter’s syndrome involves the rapid transformation of chronic lymphocytic leukemia (CLL) into a significantly more aggressive form of lymphoma, usually diffuse large B-cell lymphoma (DLBCL), but occasionally Hodgkin lymphoma (HL). It arises in 2-10% of all patients with CLL and can occur at any time in the course of the disease. The goal of treatment … Read more
Ken Karnes enjoys his whirlwind of a life. If he’s not traveling to Europe or Asia for his high-tech job — pandemics permitting — he and his wife Mary are busy keeping up with their four daughters, two sons-in-law, and three grandchildren. Road races are also on the 60-year-old’s agenda, with an eye toward his … Read more
Indolent lymphomas are types of non-Hodgkin lymphoma (NHL) that grow and spread slowly. They account for about 40% of all NHL cases in the United States and generally arise later in life. Treatment for indolent lymphomas depends on a variety of factors, including the type and stage of the disease (how far it has advanced). … Read more
Tiffany “Tiff” Trant couldn’t help but smile. All three of her children were home, and the family was deciding on dinner and a group activity. They thought about working on a puzzle, sitting down for their reoccurring poker game, or just spending the night talking. These simple pleasures have gained new meaning ever since Trant … Read more
What is BPDCN? Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive blood cancer that can affect the skin, blood, and bone marrow. It has characteristics similar to leukemias and lymphomas, but almost always first appears as lesions in the skin. What are the treatment options for BPDCN? The first drug that was … Read more
The go-to metaphor for cancer drugs known as immune checkpoint inhibitors is a brake-release lever — a means of setting loose an immune system attack on tumor cells. Helpful as it is, the analogy glosses over a highly complex mechanism involving multiple types of immune cells, cell receptors, signals, and responses — so intricate that … Read more
If you’ve been diagnosed with slow-growing lymphoma but don’t have any symptoms of the disease, your doctor is likely to recommend monitoring the disease closely but not treating it until symptoms appear — an approach known as watchful waiting. This advice might seem to run counter to the standard recommendation that cancer be treated at … Read more
Mantle cell lymphoma is a rare, often aggressive form of non-Hodgkin lymphoma (NHL), a cancer that involves white blood cells known as lymphocytes, which help protect the body from disease. It is named for its origins in the mantle zone — a ring of cells within the lymph nodes where B cells (a type of … Read more
Medically reviewed by David M. Weinstock, MD, and Eric Jacobsen, MD By banding together to study the basic biology and vulnerabilities of T-cell lymphoma, scientists at several major cancer research centers have sparked a surge of clinical trials of promising treatments for the disease. The string of new trials, some already open, some expected to … Read more
Chemotherapy has been the backbone of treatment for both untreated and relapsed/refractory (R/R) classic Hodgkin lymphoma (cHL). But treatment paradigms for cHL are changing. Immunotherapies that unmask cancer cells and make them vulnerable to our immune system, called immune checkpoint inhibitors (ICIs), were recently approved for relapsed and refractory cHL. Examples include PD-1 inhibitors such … Read more
Lymphoma comes from a type of immune cell called a lymphocyte, which is important in helping your body fight infection. The two main types of lymphocytes are B lymphocytes (B-cell) and T lymphocytes (T-cell), and each has a slightly different function in the immune system. Each can also give rise to different lymphomas. Although they … Read more
The most common symptom of lymphoma is the development of lumps under the skin. The lumps themselves are swollen lymph nodes, and they typically appear in the neck, armpit, or groin. Not all such lumps are a sign of lymphoma. It is normal for lymph nodes to swell as they fill with white blood cells as part … Read more
No athlete welcomes an injury, but a simple scratch may have saved Rich Oakley’s life. Oakley was diagnosed with cancer in 2003, as a high school senior, after a scratch from a sports injury led to a swollen neck. When the swelling didn’t subside, Oakley’s mother brought him to the doctor for tests, which revealed … Read more
Cutaneous lymphoma is a rare subtype of non-Hodgkin lymphoma that starts in the skin.
CAR T-cell therapy uses specially altered T cells — which are part of the body’s immune system — to fight cancer.
Are massages harmful for someone undergoing cancer treatment? Is it really possible they could spread lymphoma? The simple answer: No.
What does “refractory” mean medically? The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes resistant during treatment. “We would consider disease refractory if … Read more
One of the most exciting new cancer treatments, CAR T-cell therapy takes its complicated name, in part, from a fire-breathing monster in an ancient Greek myth. CAR is an acronym for “chimeric antigen receptor,” referring to genetically engineered molecules manufactured in a laboratory, inserted into the genetic material of immune T cells that have been removed from … Read more
Medically reviewed by David Reardon, MD Central nervous system (CNS) lymphoma is an extremely rare form of non-Hodgkin lymphoma that involves the brain and spinal cord, the primary components of your body’s central nervous system. Non-Hodgkin lymphoma is a type of cancer that originates in lymphocytes, infection-fighting white blood cells that make up your immune … Read more
Survival rates associated with blood cancers such as leukemia, lymphoma, and multiple myeloma have risen for patients of all ages in recent years, but this increase has been relatively smaller in adolescents and young adults – those aged 15-40 – than in children and older adults. There are likely to be multiple reasons for this, … Read more