Just over a month after approving a first-of-its-kind combination therapy for advanced melanoma, the U.S. Food and Drug Administration (FDA) has signed off on another drug combination to treat the disease. The FDA has approved a targeted therapy combination, Cotellic (cobimetinib) and vemurafenib, to treat advanced melanoma that has spread to other parts of the … Read more
This blog post originally appeared on Cancer Research Catalyst, the official blog of the American Association for Cancer Research. By Karen Honey, PhD Last week, new ground was broken in the field of cancer immunotherapy when the U.S. Food and Drug Administration (FDA) approved the first cancer treatment to combine two of these cutting-edge agents: … Read more
By Stacy Kennedy, MPH, RD When it comes to sun safety, lathering on sunscreen, sporting broad-brimmed hats and staying in the shade surely come to mind. But diet and melanoma may also be linked. Here is some information on the emerging research around obesity, antioxidant intake, vitamin D and other potential nutrition-related links to melanoma. … Read more
Sun safety applies to everyone, regardless of skin color, gender, or age. That was the message emphasized in a recent live video webchat with Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) dermatologist Jennifer Lin, MD. During the chat, Lin answered questions about the latest in melanoma treatment and prevention. “The bottom line is that UV radiation … Read more
Medically reviewed by Carlos Rodriguez-Galindo, MD Although melanoma is more commonly found in adults, childhood and adolescent melanoma affects approximately 300 children in the U.S. each year. Thankfully, the incidence rate has started to decrease in recent years. While melanoma is the least common type of skin cancer in adults, skin cancer in children is almost … Read more
The growing excitement about the potential of immunotherapy treatments for cancer continued at the 2015 meeting of the American Association for Cancer Research (AACR), one of the largest cancer research meetings of the year. Several Dana-Farber investigators presented encouraging results of immunotherapy for melanoma, lung cancer, and breast cancer. F. Stephen Hodi, MD, and Leena … Read more
Melanoma, a type of skin cancer, gets its name from the pigment-producing cells called melanocytes from which tumors can develop. Melanocytes manufacture melanin, a substance in your body that produces hair, eye, and skin pigmentation. Melanin absorbs sunlight and helps to protect skin from DNA damaging ultraviolet light which can contribute to the development of … Read more
Melanoma, the most severe form of skin cancer, results from an interaction between the genetics of the individual and damage to DNA from external factors. In the case of melanoma, most of the environmental damage is due to exposure to ultraviolet light from the sun. The cancer develops in the pigment-producing cells of the skin … Read more
“Science and Society” was the theme of this year’s American Society of Clinical Oncology (ASCO) 50th annual meeting. The meeting showcased cancer research from around the world. Some new findings from Dana-Farber researchers included: Joyce Liu, MD, MPH, of the Susan F. Smith Center for Women’s Cancers reported that, in a phase 2 clinical trial, … Read more
Although skin cancer is the most common cancer in the United States, melanoma accounts for less than 2 percent of all skin cancer cases. The disease is the most aggressive form of skin cancer. Melanoma begins in the melanocytes, which are found on the lower part of the epidermis. The disease can occur anywhere on … Read more
It’s well known that excessive sunning and sunburns can foment the development of malignant melanoma, the deadliest skin cancer. Now, in a preliminary study, scientists have suggested that drinking alcohol may be an added risk factor for the disease.
As recently as five years ago, progress in treating life-threatening malignant melanoma was slow. Since then, several molecularly targeted drugs have burst on the scene, and new strategies for awakening the immune system to attack the cancer cells have yielded dramatic long-term survival benefits for some patients. “The outlook for patients has never been so … Read more
Often caused by excessive exposure to ultraviolet (UV) rays in sunlight, melanoma accounts for only 4 to 5 percent of skin cancer cases, but is responsible for most skin cancer-related deaths. As with many forms of cancer, melanoma is often misunderstood, and myths persist. When detected and treated in its earliest stages, however, melanoma is often … Read more
As we close out the first quarter of the twenty-first century, it isn’t hard to notice how much the world has changed since the year 2000. Smartphones. Social media. Artificial intelligence. But how much has cancer care changed? A lot. Possibly more than you think. Treatment for many cancers now include many options beyond chemotherapy, … Read more
Gene therapy and immunotherapy are both types of treatment for cancer and other diseases. They represent different approaches to disease therapy, though there is some overlap. What is gene therapy? Gene therapy is a way of treating or preventing disease by altering the genetic instructions within an individual’s cells. Most diseases aren’t caused by a … Read more
What is TIL (tumor-infiltrating lymphocyte) therapy? Tumor-infiltrating lymphocyte, or TIL, therapy uses a patient’s own immune system T cells to fight cancer. The therapy involves removing T cells from a piece of the patient’s tumor – where the T cells have congregated after being alerted to the cancer – growing them outside the body, then … Read more
Immunotherapy drugs can be more effective against cancer when combined with other therapies, such as radiation therapy, targeted drugs, immunotherapy agents, and with chemotherapy. What is chemotherapy? Chemotherapy drugs have been used for decades to treat cancer, either alone or in combination therapies. These drugs kill rapidly dividing cells, including tumor cells, using a variety of mechanisms. … Read more
Cancer research often focuses on gene mutations in the parts of the human genome that produce cellular machinery called proteins. But the rest of the genome — sometimes called the “dark genome” — can also play a role. Dana-Farber researcher William Freed-Pastor, MD, PhD, a physician-scientist in the Dana-Farber Center for Gastrointestinal Oncology and Hale … Read more
Cold plunges, the act of immersing the body in cold water for therapeutic benefit, have been used for centuries — from vinterbading in Scandinavia (swimming in cold water during winter months) to misogi in Japan (a Shinto practice of purifying the body under a cold or icy waterfall) to ice baths in the United States … Read more
Medical advances tend to unfold slowly over many years, fueled by successive clinical studies that build upon each other and together provide the evidence needed to change patient care. A key illustration of this point comes from a recent phase 3 clinical trial, published last October in the New England Journal of Medicine (NEJM), which … Read more