Ewing sarcoma is a cancer that grows in the bones and soft tissues, usually in the thigh or pelvis. It is most common in children and young adults between the ages of 5 and 20, and more common in boys than girls. Although most patients are teenagers, Ewing sarcoma can sometimes occur in older adults … Read more
Twenty-year-old Amanda Lee has always wanted to be a nurse. But after a life-changing diagnosis in 2012, Lee suddenly had a more personal motivation to pursue her career goals. After seeing her primary care doctor for pain in her lower back, doctors determined Lee had a tumor that was causing internal bleeding. Lee, then 17, … Read more
Cancers known as sarcomas develop in the connective tissues, such as muscle, fat, and bone, that hold the body together. The type of sarcoma called liposarcoma originates in fat cells that have been driven by random DNA errors into malignant growth, forming tumors. George Demetri, MD, director of Dana-Farber’s Center for Sarcoma and Bone Oncology, … Read more
If your son or daughter has been diagnosed with a type of sarcoma – a tumor in connective tissue like muscles or bones – there are many questions: Will my child make a full recovery? What are the immediate and long-term side effects of treatment? Most parents don’t consider whether their child will face a … Read more
Patti Keenan was a senior in high school before learning that the mysterious disease she was treated for twice as a young girl in the 60s was, in fact, a rare form of cancer. Her parents, not wanting to frighten Patti at a time when pediatric cancer survival rates were much lower, kept their daughter’s … Read more
Like a mill crumbling into a river, solid tumors constantly shed bits of themselves — including their DNA — into the bloodstream. This free-floating genetic material, known as circulating tumor DNA, or ctDNA, contains a trove of information about the tumor. Advances in technology have made it possible to extract ctDNA from a blood sample, … Read more
The cell cycle is the series of steps by which living cells grow, duplicate their DNA, and divide into two identical daughter cells, each receiving one copy of the doubled material. The cycle is complete when each daughter cell is sealed in its own membrane, ready to start the cycle again. The cycle occurs in … Read more
Over the past three decades, the number of cancer survivors has increased. That trend is expected to continue. The numbers indicate progress in the treatment of cancer, but they also underscore the importance of quality of life after cancer. “We want people to lead healthy, productive, enjoyable lives, and mobility is such an important piece … Read more
A recent study found that women who frequently use chemical hair straighteners and relaxers could have a higher risk of developing uterine cancer than those who have not used the products. The study, which tracked 34,000 women nationwide for more than a decade, comes at a time when uterine cancer rates in women are increasing, … Read more
Uterine cancer — also known as endometrial cancer — has traditionally been classified as endometrioid or non-endometrioid based on the appearance of the tumor cells under a microscope. Now, as scientists learn more about the molecular makeup of the disease, uterine cancers are increasingly identified by the specific genetic alterations within them. Endometrioid uterine tumors … Read more
Of all the mutated, blundering, havoc-wreaking genes in cancer cells, few are more ubiquitous than TP53. The gene, which in its normal, capable form is nicknamed the “guardian of the genome,” is found in a flawed form in almost every type of cancer, including up to half of all lung, ovarian, and colorectal cancers and … Read more
Among the most memorable on-air guests during the first WEEI/NESN Jimmy Fund Radio-Telethon — a live, 36-hour broadcast held each summer to benefit Dana-Farber patient care and research — was Todd Schwartz, a 19-year-old patient in Dana-Farber’s Jimmy Fund Clinic. Here, Todd’s mother, Janet Schwartz, reflects on her son’s appearance that day in 2002, his … Read more
Picture a floor strewn with broken crockery, hastily and haphazardly pieced back together, and you’ll have a sense of the chromosomal chaos inside many cancer cells. In a phenomenon known as chromothripsis, a chromosome or piece of chromosome shatters and reassembles almost randomly, mangling its genetic information. It’s a common feature of cancer cells, found … Read more
If COVID-19 has taught us anything, it’s that with funding and regulatory support, the scientific community can move quickly and produce miracles. So when President Joe Biden announced his commitment on Feb. 2, to cut cancer deaths by 50 percent over the next 25 years, it produced a wave of guarded optimism. “This is great … Read more
The immune cells known as natural killer (NK) cells are part of the body’s first line of defense against cancer. Many efforts are underway to harness NK cells as a form of cancer immunotherapy, but a critical question in the field remains: Why do some tumors tend to be sensitive to NK cells’ attacks while … Read more
Researchers at Dana-Farber and the Broad Institute of MIT and Harvard have created a novel Molecular Oncology Almanac that combines an algorithm, or computational method, for interpreting genomic alterations in a patient’s tumor, along with a knowledge base of molecular changes reported to be associated with tumor behavior. They say that the components of this … Read more
Cancers originating in the bone, called primary bone cancers, are rare and account for less than 1% of all cancers. There are numerous types of primary bone cancers, and in most cases, the cause isn’t known. Primary bone tumors can have changes in the DNA of the cancer cells, but those DNA changes are acquired … Read more
The shock of a new cancer diagnosis was still settling in for Isabel Nordby when she and her parents made a decision that could greatly impact the teenager’s future — if and when the time is right. Before starting her chemotherapy protocol for Ewing sarcoma in April 2020, Isabel, then 15, had one of her … Read more
Widespread testing of pediatric tumors has confirmed a long-held suspicion: far more of them have hereditary roots than was once thought. Physicians and researchers now estimate that at least 10% of cancers in children and adolescents, and probably many more, are linked to hereditary genetic mutations that increase cancer risk. The findings have changed the … Read more
Many cancers develop from cells that have a malfunctioning tumor suppressor gene, p53, which normally helps control unchecked cell growth and prevent cancer. Some scientists are pursuing a strategy of restoring p53 gene function in cancer cells to stop their unruly growth or kill them. The exact effects of reviving p53 activity in tumors are … Read more