Set to begin radiation therapy the next day, the patient was anxious. Not just about her thoracic cancer treatment, but also about the oral chemotherapy she took at home. It came with high insurance copays. Then came a phone call that eased her concerns. As they had earlier in her treatment, members of Dana-Farber’s Specialty … Read more
For many patients with lymphoma or multiple myeloma, a stem cell transplant with their own stem cells (an autologous transplant) or CAR T-cell therapy can extend life significantly or even cure the disease. A variety of factors influence which of these two treatments is recommended, including: What is the difference between stem cell transplant and … Read more
Of all the mutated, blundering, havoc-wreaking genes in cancer cells, few are more ubiquitous than TP53. The gene, which in its normal, capable form is nicknamed the “guardian of the genome,” is found in a flawed form in almost every type of cancer, including up to half of all lung, ovarian, and colorectal cancers and … Read more
The views discussed in this piece do not represent the U.S. Government. Sara Minkara lost her sight at the age of seven due to juvenile macular degeneration — a rare genetic condition — but she has never allowed that to slow her down. Once she grew up, she made her life’s goal helping the world … Read more
Carcinomas and sarcomas are different types of cancer. Carcinomas are much more common than sarcomas, but the biggest difference between them is where they occur in the body. Carcinomas are usually named for the location where they arise (such as breast cancer, colon cancer). Sarcomas can occur in many different body locations and are generally … Read more
Asked how he has dealt with three bouts of bone cancer and a partial right leg amputation in less than four years, 14-year-old Jack Berry says that he takes things “one step at a time.” That is, when he’s not surfing, riding his mountain bike, sprinting across tennis courts, or winning ski races. An osteosarcoma … Read more
The patient’s medical history told of a grueling journey. From the age of six, when the patient began experiencing weakness on her left side and double vision, she had to undergo repeated blood draws to reduce dangerously high levels of red blood cells. Over the next eight years she needed higher and higher doses of … Read more
A cytokine storm is a severe immune system reaction to infection, autoimmune condition, or other disease, including some cancers. It occurs when the body produces extremely high levels of certain cytokines, which are proteins that raise or lower immune activity. The deluge of cytokines into the bloodstream can result in severe inflammation across multiple bodily … Read more
Tumors are scrupulous recorders of their own life stories. The wreckage they acquire as a result of therapy, the stratagems they use to survive and dodge an immune attack are all inscribed in their DNA and the set of immune system cells within them. Unfortunately for science, the autobiography of a tumor rarely consists of … Read more
Treatment for acute forms of adult leukemia has advanced markedly since the days when all patients generally received the same course of treatment. A patient’s age and overall health, the type of leukemia he or she has, and the goal of therapy all influence the treatment plan. What are the types of acute leukemia? There … Read more
At 4:00 a.m. on a mid-March morning, while most of the country was hunkering down due to the COVID-19 pandemic, Jennifer Huber began the long drive from her home in the Hudson Valley Region of New York to Boston. With her was her 14-year-old daughter, Emma Levine, who was suffering from excruciating headaches caused by … Read more
For almost half of his life, Michael Murray has had to grapple with cancer, including multiple relapses. One of his hardest setbacks was hearing that his cancer had returned just weeks before he was set to start his freshman year at Boston College. With the news, Murray worried that his future would be in jeopardy. … Read more
Insights from decades of cancer research are surprisingly transferable to the battle against COVID-19. The desire to save life and ease suffering that motivates cancer researchers has been directed to the new disease as well. Drawing on their knowledge of cancer drug mechanisms, and of the adverse side effects of some of those drugs, Dana-Farber … Read more
For years, Donna Martin carried a piece of scrap paper with the words “dyskeratosis congenita,” which she believed might explain her son Brad’s sudden, mysterious affliction. A routine blood test had revealed Brad’s bone marrow was failing, unable to keep up with his need for healthy blood cells. His condition, Donna knew, would worsen over … Read more
The wolf at the door is a harmless annoyance compared to the wolf in the house. However dangerous the novel coronavirus is as an infectious agent, it can’t do any harm if it’s locked out of a cell. Strategies to bar the coronavirus (COVID-19) from entering cells — thereby preventing infection and averting transmission of … Read more
As scientists race to develop and test new treatments for COVID-19, Dana-Farber’s Wayne Marasco, MD, PhD, and his lab team are bringing one of the world’s most formidable resources to the effort: a “library” of 27 billion human antibodies against viruses, bacteria, and other bodily invaders. The collection, created by Marasco and his associates in … Read more
Regular exercise helps maintain your well-being and can be especially necessary during times of acute stress. Working out — or performing moderate to vigorous physical activity that elevates your heart rate and activates muscles — can have numerous positive effects on your health, both physically and emotionally. Exercise has been shown to reduce stress and … Read more
More than 40 years after a then-experimental bone marrow transplant for aplastic anemia, Jessica Brilliant Keener is thriving — and giving back every day to the institutions that gave her a second chance at life. Aplastic anemia occurs when bone marrow needed to supply all the body’s blood cells produces too few of those required … Read more
This post originally appeared on Discoveries, the blog of Boston Children’s Hospital. Eva Quiroz loves horses. The 10 year old takes riding lessons, and this activity puts a smile on her face. Anyone watching her contentedly guiding a horse around the ring would just assume she has always been a healthy child, says her mom … Read more
Medically reviewed by Geoffrey Shapiro, MD, PhD, and Christopher French, MD Although it is one of the most aggressive solid tumors in humans, NUT carcinoma responds better to treatment in some patients than others. Due to its rarity, specific statistics on incidence and prevalence are limited; it is estimated that NUT carcinoma is diagnosed in … Read more