The team representing Dana-Farber’s Young-Onset Colorectal Cancer Center called Team Beyond CRC (colorectal cancer) is looking forward to the fast-approaching Boston Marathon® Jimmy Fund Walk presented by Hyundai taking place on Sunday, October 2. Team Beyond CRC will be among 90 other employee-led teams participating in the Jimmy Fund Walk. This longtime annual event brings … Read more
Logic said that drugs known as PARP inhibitors would work as well — and perhaps even better — in breast cancer marked by BRCA gene mutations than in ovarian cancer carrying the same abnormalities. Clinical results said otherwise. Patients with relapsed, BRCA-mutated ovarian cancer survive longer, overall, with PARP inhibitor treatment than any other therapy. … Read more
Over the years, a variety of studies have suggested that aspirin use is associated with reduced ovarian cancer rates, but a recent study filled in some important details, showing that frequent aspirin use is linked to a lower risk of the disease in people with multiple risk factors. The study, led by researchers at the … Read more
Championship rower Dan Lynch is used to fighting against the current. Most people start the sport in their teens or twenties. Lynch dropped oars at 53 on a whim. Today, it isn’t a mere hobby. He’s now pursuing the longest-known streak of consecutive days on an indoor rowing machine. Not even mantle cell lymphoma, a … Read more
Lianne Kraemer describes two breast cancer diagnoses before age 40 — including metastatic breast cancer (MBC) that had spread to her brain — as “slamming into one brick wall, getting back on life’s highway, and then slamming into another.” Now, as she continues navigating her way with the disease, Kraemer is helping those traveling a … Read more
Sixty years to the day after President John F. Kennedy’s landmark speech pledging to land an American on the moon by the end of the decade, President Biden came to Boston on September 12 to recommit the country to a different kind of moonshot — “ending cancer as we know it.” Speaking at the John … Read more
Of all the mutated, blundering, havoc-wreaking genes in cancer cells, few are more ubiquitous than TP53. The gene, which in its normal, capable form is nicknamed the “guardian of the genome,” is found in a flawed form in almost every type of cancer, including up to half of all lung, ovarian, and colorectal cancers and … Read more
The views discussed in this piece do not represent the U.S. Government. Sara Minkara lost her sight at the age of seven due to juvenile macular degeneration — a rare genetic condition — but she has never allowed that to slow her down. Once she grew up, she made her life’s goal helping the world … Read more
Non-small cell lung cancers (NSCLCs) that are most loaded with genetic mutations are most susceptible to immunotherapy drugs known as PD-L1 inhibitors, a new study by Dana-Farber researchers shows. The study, published recently in JAMA Oncology, can help doctors identify patients with the disease who are likely to benefit from the drugs, which foil tumors’ … Read more
Jared Olinski was lifting his four-year-old son off of the floor when he felt three sharp pops in his back followed by pain. At first, cancer wasn’t on his radar. Olinksi was only 35 at the time. “I assumed I pulled a muscle,” Olinski remembers. His primary care physician thought it was a slipped disk … Read more
As a marathon runner, Kara Niewohner knows a thing or two about perseverance. This same trait that propels her through the 26.2 miles of each marathon course served her well through her quest for a second opinion after being diagnosed with triple-negative breast cancer with a BRCA2 mutation — one that led her to Dana-Farber. … Read more
Difficulty swallowing, known as dysphagia, can come in many forms. Some people with dysphagia may experience issues in the oral phase or mouth. This is characterized by one or more of the following: holding food in the cheek without being aware of it due to weakness difficulty moving the food around the mouth leakage of … Read more
Discovered only about a decade ago, a key actor in the immune system called STING has become a hot target of research aimed at improving cancer immunotherapy. STING (stimulator of interferon genes) has been called a “master regulator” of the innate immune response against cancer. When activated by substances called agonists, STING turns on genes … Read more
Among the most memorable on-air guests during the first WEEI/NESN Jimmy Fund Radio-Telethon — a live, 36-hour broadcast held each summer to benefit Dana-Farber patient care and research — was Todd Schwartz, a 19-year-old patient in Dana-Farber’s Jimmy Fund Clinic. Here, Todd’s mother, Janet Schwartz, reflects on her son’s appearance that day in 2002, his … Read more
Technically speaking, a tyrosine kinase is an enzyme that transfers a compound called a phosphate group from ATP — a molecule that stores energy — to a specific area on cell proteins. It helps transmit the signals that cause cells to grow and divide and to perform specific functions in the body such as burning … Read more
Two major obstacles once stood in the way of exploring the basic biology of diffuse midline glioma in children. And one of them was the brain itself. The cancer, a subtype of high-grade glioma, forms in some of the most critical parts of the brain, in regions that control such basic functions as breathing, swallowing, … Read more
With its deep experience in studying the rare, often lethal cancer known as NUT carcinoma, Dana-Farber Brigham Cancer Center attracts patients and families, some from far away. Unfortunately, NUT carcinoma is so rapidly aggressive that “sometimes patients get to Dana-Farber and become too sick to proceed with treatment,” which speaks to the urgent need for … Read more
Anne Keane is a big fan of counting, from laps swam to miles ran to birthdays celebrated by her daughter Ruby. The most recent was Ruby’s seventh, and Keane plans on marking many more as she continues enjoying an active lifestyle with metastatic breast cancer (MBC). “We’re just so lucky to get to wake up … Read more
Mark Signer uses his voice to raise awareness about anaplastic thyroid cancer — something he thought impossible two years ago. When he was diagnosed with this highly aggressive cancer in July 2020, he was told to get his affairs in order. And when he awoke from the surgery that removed his tumor, he couldn’t speak; … Read more
Like a fugitive from justice, cancer cells stake their survival on their ability to remain inconspicuous. In many cases, however, they are decked out in molecules – called tumor-associated antigens and neoantigens – that shout “cancer!” to the immune system and prompt a potent antitumor response. But tumor cells have other means of dodging an … Read more