Newly Identified Regulator in Prostate Cancer Cells Could Serve as Drug Target for Advanced Tumors

Treating advanced prostate cancer typically involves surgery — to reduce levels of testosterone, which fuels the growth of tumors — or giving drugs that blockade the androgen receptor (AR), which responds to testosterone by stimulating cancer-growth genes. While these measures can keep the disease at bay initially, resistance almost always occurs as the androgen receptor … Read more

Earlier Use of CAR T-Cell Therapy Approved for Relapsed Large B-cell Lymphoma Patients

Patients with large B-cell lymphoma (LBCL) who did not respond to initial treatment or relapsed within a year may now receive the CAR T-cell product axicabtagene ciloleucel (Yescarta) as a second-line therapy, following approval by the U.S. Food and Drug Administration (FDA) based on results of a recent clinical trial. Until now, the standard of … Read more

Seeking Stem Cell Transplant, Basketball Expert Makes Slam Dunk Decision

As an economist specializing in statistical analysis, Dan Rosenbaum has done everything from help the federal government use more evidence in its decision-making to assist several National Basketball Association (NBA) teams in finding and signing the best players. Research and number-crunching are his expertise, so when Rosenbaum learned he needed a life-saving stem cell transplant … Read more

Study Calls for Fresh Look at Disparities in Breast Cancer Treatment

For as long as researchers have known about disparities in cancer treatment, they’ve sought to explain them. Do some patients receive different care than others because of race, age, wealth, or gender? Or does the region where they receive treatment matter most? Only by answering questions like these can researchers know where to focus their … Read more

What is a Stereotactic Breast Biopsy?

An annual physical or mammogram can help detect lumps or abnormalities in the breast, but these exams cannot tell whether a growth is cancerous or noncancerous. If a breast lump or abnormality is found in your breast, your doctor may advise you to have a breast biopsy. A stereotactic breast biopsy is a kind of … Read more

Junior Dana-Farber Analyst Named to Forbes Healthcare’s 30 under 30

At 28 years old, Dana-Farber bioinformatics analyst Carino Gurjao is already making a splash in the field of colorectal cancer research. He is coming off the back of a big year: The Paris-born researcher was named to Forbes Healthcare’s 2022 30 Under 30 list for his role in the Giannakis Lab at Dana-Farber, which identified … Read more

Addressing the Impact of Poverty on Childhood Cancer

Approximately one in three children in the United States lives in a low-income home. For childhood cancer patients, living in a low-income home can have a significant impact: Poverty and associated factors are linked to poorer outcomes, even at large academic medical centers like Dana-Farber, according to research by Kira Bona, MD, MPH, a pediatric … Read more

Experts Tackle Relationship Between Environmental Chemicals, Pollution, and Cancer

Many healthy people are concerned about potential risks from exposures to air and water pollution, household chemicals, pesticides, and substances in the workplace. And for cancer patients, it can raise even more anxiety, with people wondering whether something in their environment triggered their disease. However, links between environmental exposures and cancer have been difficult to … Read more

Narjust Duma, MD: Forging a Path for Underrepresented Communities in Medicine

The connection between a researcher’s biography and area of study is not always obvious. A young scientist may discover an intellectual fascination with immunology, for example, despite not having known anyone with an immunological disorder. For Dana-Farber’s Narjust Duma, MD, however, research is not just a response to her life experiences. It’s a way to … Read more

Researchers Urge Efforts to Improve Diagnosis and Care of Patients with Disabilities that Affect Mobility

People with disabilities that affect their mobility often face special challenges when diagnosed with cancer. Beyond logistical matters such as getting to and from medical appointments, they may be diagnosed with more advanced, harder-to-treat cancer than non-disabled individuals, making them more likely to die of their disease, research suggests. While most previous studies of these … Read more

Doctor Who Treats HIV/AIDS Shares Lessons From 40 Years Fighting Health Disparities

Valerie Stone, MD, MPH, was considering becoming an oncologist in the mid-1980s when something happened to shift her focus. People, including some very close to her, began developing a mysterious new disease. What they had was eventually identified as acquired immune deficiency syndrome, or AIDS. And as a member of two groups disproportionately impacted — … Read more

Mucosal Melanoma: What You Need to Know

While skin cancer is one of the most common types of cancer in the United States, melanoma is the least common type of skin cancer, accounting for less than 1 percent of skin cancer. Unlike most melanomas appearing on visible areas on the skin, mucosal melanoma occurs on the mucus membranes, or moist surfaces, of … Read more

Director of the Lynch Syndrome Center Shares his Personal Connection to Lynch Syndrome

Because of his adopted family’s cancer history, the director of Dana-Farber’s Lynch Syndrome Center, Matt Yurgelun, MD, is uniquely invested in helping patients with Lynch syndrome — a common and often under-diagnosed inherited condition. Eight of the 13 in his grandfather’s generation ultimately developed some form of cancer, and it wasn’t until later that Matt … Read more

Researchers Identify Promising Drug Target in Pediatric Neuroblastoma

Investigators had culled the list of suspects down to two. But which one was the guilty party, or were both? The pair worked together so seamlessly, it was difficult to tell where one’s role began and the other’s ended. In some respects, they even looked alike. Dana-Farber scientists have now teased apart the relationship between … Read more

Providing Emotional Support to Young Patients with Colorectal Cancer

Cancer is a disease that’s often associated with older people; however, a growing number of younger patients are being diagnosed with colorectal cancer. Since the 1990s, the rate of colorectal cancer diagnoses has more than doubled in adults age 20 to 49. Alexa Morell is one of these patients. She didn’t expect her diagnosis: metastatic … Read more