One of the ways of classifying breast cancers is by the level of a protein called HER2 on the surface of tumor cells. HER2, which stands for human epidermal growth factor receptor 2, helps control how breast cells grow, divide, and repair damage. Breast cancers marked by high levels of HER2 are known as HER2-positive … Read more
Just over a year after giving birth to her son, Emmett, Abigail Myers faced a devastating diagnosis of breast cancer in March 2014. It started when Myers woke up one morning feeling sore. When she found a lump, she rushed to her doctor, all the while in disbelief that she might have cancer. A resident … Read more
Millions of people regularly take or use contraceptives, such as birth control pills, to avoid unwanted pregnancy or relieve menstruation-related side effects such as cramps or heavy bleeding. There is some evidence that contraceptives may affect cancer risk — specifically, that oral contraceptives may increase the likelihood of developing breast and cervical cancers but reduce … Read more
At first, Joy Mills and Arthur “Buck” Benedict look like any other happy, older couple traveling by ferry from their home on Peaks Island, Maine, to Portland. Admiring the beautiful views, they sit outside when weather permits. They laugh, chat with friends, and occasionally needle each other during the 18-minute trip. Once a month, the … Read more
When Jennifer Fullerton was diagnosed with breast cancer at age 29, her mind immediately went to the worst-case scenario. “I thought I was going to die. That first day all I could think was ‘why me,’” Fullerton says. “My mom very poignantly told me, ‘Today you can say ‘why me,’ but tomorrow, ‘why not me’. And you … Read more
Nancy Arsenault was taking a lunch break from driving her elementary school bus route in her hometown of Stow, Massachusetts, when she began to experience double vision. She had been first diagnosed with pre-invasive breast cancer in 2006, which recurred in 2011. In 2019, she developed an invasive breast cancer in her chest wall and … Read more
Plant-based diets have many known health benefits, but can they reduce the risk of breast cancer? In fact, some evidence suggests that people who eat rich in non-starchy vegetables may be at lower risk of some kinds of breast cancer. However, Dana-Farber physician and researcher Jennifer Ligibel, MD, cautions that the evidence that consuming a … Read more
Logic said that drugs known as PARP inhibitors would work as well — and perhaps even better — in breast cancer marked by BRCA gene mutations than in ovarian cancer carrying the same abnormalities. Clinical results said otherwise. Patients with relapsed, BRCA-mutated ovarian cancer survive longer, overall, with PARP inhibitor treatment than any other therapy. … Read more
Lianne Kraemer describes two breast cancer diagnoses before age 40 — including metastatic breast cancer (MBC) that had spread to her brain — as “slamming into one brick wall, getting back on life’s highway, and then slamming into another.” Now, as she continues navigating her way with the disease, Kraemer is helping those traveling a … Read more
Anne Keane is a big fan of counting, from laps swam to miles ran to birthdays celebrated by her daughter Ruby. The most recent was Ruby’s seventh, and Keane plans on marking many more as she continues enjoying an active lifestyle with metastatic breast cancer (MBC). “We’re just so lucky to get to wake up … Read more
Results of several phase 3 trials and dozens of other studies led by Dana-Farber researchers were presented online and in person June 3-7 at the 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO), the world’s largest clinical cancer research meeting. Some of the research reports presented by Dana-Farber investigators include: Improved progression-free … Read more
For as long as researchers have known about disparities in cancer treatment, they’ve sought to explain them. Do some patients receive different care than others because of race, age, wealth, or gender? Or does the region where they receive treatment matter most? Only by answering questions like these can researchers know where to focus their … Read more
An annual physical or mammogram can help detect lumps or abnormalities in the breast, but these exams cannot tell whether a growth is cancerous or noncancerous. If a breast lump or abnormality is found in your breast, your doctor may advise you to have a breast biopsy. A stereotactic breast biopsy is a kind of … Read more
A diagnosis of breast cancer can be a shock at any age, but breast cancer in young people often presents a unique set of issues. In addition to managing a serious illness, younger people diagnosed with breast cancer may also be early in their careers and raising families or planning to start a family in … Read more
Like many people, Caroline McGuirk knew that lumps can be a symptom of breast cancer, even if most of them end up being noncancerous. What she wasn’t aware of is that the redness and swelling she had noticed in her right breast months before finding two lumps there can be indicators of inflammatory breast cancer … Read more
What is osteoporosis? Osteoporosis is a condition that thins and weakens the bones in a way that makes them more likely to fracture, especially the bones in the hip, spine, and wrist. Are there any risk factors for osteoporosis? Osteoporosis can occur to anyone, but it is more common in older women. Risk factors include: … Read more
Clinical trials are research studies that test new therapies or existing treatments to better understand their safety and efficacy. Every treatment that is now approved by the U.S. Food and Drug Administration (FDA) was tested in a clinical trial involving patients who volunteer, usually after a discussion with their physician. The clinical trial system is … Read more
When breast cancer spreads, or metastasizes, it’s more likely to travel to some parts of the body than others. The most common sites of metastasis include the bones, brain, liver, or lungs. It’s rare for patients with early-stage breast cancer, which has not spread beyond the breast or adjacent lymph nodes, to develop a brain metastasis: … Read more
A relatively small proportion of breast cancers are caused by alterations in inherited genes that sharply increase the lifetime risk of developing breast cancer. One of these genes has recently been receiving new attention: PALB2, a potent breast cancer susceptibility gene related to the better-known BRCA1 and BRCA2 genes. Someone who inherits a PALB2 mutation faces … Read more
Treatment for breast cancer is generally based on the type of breast cancer, its stage, and other factors. Increasingly, care teams are devising treatment plans by looking at the molecular subtype of each breast cancer. The various subtypes of breast cancer behave and grow in different ways, and can be divided based on different genes … Read more