Graft Sculpting Brings New Approach to Stem Cell Therapy for Highest Risk AML Patients 

A novel hematopoietic stem cell transplantation (HSCT) method utilizing ‘graft sculpting’ is being tested in a phase 1 clinical trial in patients with refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who are at the highest risk of relapse after ‘standard’ transplants. In fact, the patients in the trial don’t qualify for a standard … Read more

Dana-Farber Researchers Use Machine Learning to Understand Rare Familial Blood Cancer

Waldenström’s macroglobulinemia (WM) is a blood cancer that is extremely rare, affecting around 1500 people in the US each year. About 20 percent of those cases are considered familial, meaning that many members of the same family also have some form of blood cancer, such as myeloma or lymphoma.  An even smaller group — five … Read more

Prostate Cancer Rates Raise Concerns: What You Should Know

Overall, cancer death rates have declined by 33% since 1991, according to a Jan. 2023 American Cancer Society report. Multiple cancers like leukemia, melanoma, and kidney cancer have seen significant declines in mortality due to great advances in treatments.   Prostate cancer rates had been on the decline for two decades, but the ACS report remarks that … Read more

How to Manage Digestive Issues During and After Chemotherapy

It’s quite common to experience digestive troubles while undergoing chemotherapy and even for some time after treatment. Since many chemotherapies target fast-growing cells, like cancer cells, they can disrupt the growth of some cells involved in digestion. In some cases, vomiting, nausea, diarrhea, and constipation can be the result, all of which can be uncomfortable … Read more

Stem Cell Transplant and CAR T-cell Therapy: When Are They Used for Lymphoma and Multiple Myeloma?

For many patients with lymphoma or multiple myeloma, a stem cell transplant with their own stem cells (an autologous transplant) or CAR T-cell therapy can extend life significantly or even cure the disease. A variety of factors influence which of these two treatments is recommended, including:  What is the difference between stem cell transplant and … Read more

Do Contraceptives Reduce or Increase the Risk of Cancer?

Millions of people regularly take or use contraceptives, such as birth control pills, to avoid unwanted pregnancy or relieve menstruation-related side effects such as cramps or heavy bleeding.   There is some evidence that contraceptives may affect cancer risk — specifically, that oral contraceptives may increase the likelihood of developing breast and cervical cancers but reduce … Read more

Living with Metastatic Breast Cancer, Valentines Ferry On

At first, Joy Mills and Arthur “Buck” Benedict look like any other happy, older couple traveling by ferry from their home on Peaks Island, Maine, to Portland. Admiring the beautiful views, they sit outside when weather permits. They laugh, chat with friends, and occasionally needle each other during the 18-minute trip.  Once a month, the … Read more

Treatment Advances and Perfect Partners Give Pancreatic Cancer Patient ‘Gift of Time’

After losing her first husband of 30 years to cancer, Candace “Candy” Langford felt blessed to find love again. And when she learned six weeks after her June 2018 wedding that she had locally advanced pancreatic cancer, shock blended with sorrow — because she knew her new life partner had also been down that road … Read more

Metastatic Prostate Cancer Can’t Slow Down Grandfather

Doug Kroc taught social studies for 40 years, but these days the retiree is more interested in making history than teaching it. Not the kind of events found in textbooks, but simple moments spent swimming and kayaking with his family or riding his bike along the backroads of Vermont. So when Kroc, 70, developed a … Read more

Autologous or Allogeneic Stem Cell Transplants: Which Will My Doctor Recommend?

Both allogeneic and autologous stem cell transplants involve treating a patient with chemotherapy followed by an infusion of blood-forming stem cells, with a goal of curing the cancer or extending the time before the disease relapses. In adults, transplants are used to treat a range of blood-related cancers, myelodysplastic syndromes, and non-malignant blood disorders. Autologous … Read more

Mother with Rare Type of Brain Metastasis Doing Well on Novel Treatment

Langley Perer thought her breast cancer was in the rearview mirror. In 2017, she had received a shocking diagnosis at age 35 of ductal in situ carcinoma (DCIS), the earliest form of breast cancer. “As far as I knew, I had no family history of breast cancer,” she says. DCIS is sometimes referred to as … Read more

Breast Cancer Patient Achieves Her Dreams Thanks to Dana-Farber Care 

When Jennifer Fullerton was diagnosed with breast cancer at age 29, her mind immediately went to the worst-case scenario. “I thought I was going to die. That first day all I could think was ‘why me,’” Fullerton says. “My mom very poignantly told me, ‘Today you can say ‘why me,’ but tomorrow, ‘why not me’. And you … Read more

Research Into Cellular Recycling System Reveals New Vulnerability in Pancreatic Cancer

Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. All cells in the body recycle minerals and nutrients, removing them from storage and breaking them down them for re-use. But in cancer cells, this process, known as autophagy — literally, … Read more

CNS Lymphoma Patient Grateful For Healthy New Chapter of Family Life

Brian Humberd firmly believes in an attitude of gratitude. The biotech recruiter from Melrose, Massachusetts remains eternally grateful to Dana-Farber medical oncologist David Fisher, MD, who not only recommended a life-saving stem cell transplant to treat his central nervous system (CNS) lymphoma, but whose advice enabled Humberd to become a father after his cancer treatments. … Read more

Can Hair Relaxers and Straighteners Cause Uterine Cancer?

A recent study found that women who frequently use chemical hair straighteners and relaxers could have a higher risk of developing uterine cancer than those who have not used the products. The study, which tracked 34,000 women nationwide for more than a decade, comes at a time when uterine cancer rates in women are increasing, … Read more

Mother, Community Leader with Breast Cancer Has Remarkable Response to Immunotherapy

Nancy Arsenault was taking a lunch break from driving her elementary school bus route in her hometown of Stow, Massachusetts, when she began to experience double vision. She had been first diagnosed with pre-invasive breast cancer in 2006, which recurred in 2011. In 2019, she developed an invasive breast cancer in her chest wall and … Read more