Six Tips to Help Young Adults Cope with Cancer

Getting cancer can be particularly difficult for young adults – classified by the National Cancer Institute as ages 15 to 39. Because the disease is relatively rare in this age group, these younger patients may find themselves isolated – too old to fit easily into childhood cancer programs, and too young to find peers in adult clinics (most people diagnosed with cancer are 55 or older).

But the outlook is getting brighter.

Read more

Dr. Jay Harris discusses the link between radiation therapy for breast cancer and heart disease

By Robert Levy

In a recent study, Oxford University researchers reported that although radiation therapy is a critical tool for the treatment of women with breast cancer, it can also raise their risk of a heart attack or heart disease later in life. The study was based on a review of medical records of 2,168 women in Sweden and Denmark who received radiation therapy for breast cancer between 1958 and 2001, and who were under age 70 at the time.

News coverage of the study, published in the New England Journal of Medicine, has drawn new attention to the heart risks associated with radiation therapy even as it underscores such therapy’s role in improving survival rates for breast cancer patients.

Read more

How Do Cancer Drugs Block Pathways?

by Richard Saltus   

Cells are like young children – they need a lot of guidance on how to behave. Your body’s cells are constantly getting that help – in the form of hormones, growth factors, and other chemicals telling them when to rest, grow, duplicate their DNA, divide, or even self-destruct.

These commands are relayed from the cell’s surface to its nucleus by molecular pathways, also called signaling pathways, which are a series of interacting proteins that relay cellular messages, much as cell phone towers relay phone calls. When the commands reach the cell nucleus, they activate or turn off genes to determine how the cell responds.

Read more

Why Should I Get a Colonoscopy? (Colorectal Cancer)

Colonoscopy exams get a bad rap. Even though such exams are brief and painless, many people fear and avoid them. Roughly one third of Americans for whom the exams are recommended are not getting them. Yet colonoscopy is one of the most effective of all cancer prevention methods. As many as 60% of colon cancer deaths could be … Read more

What Happens If You’re Allergic to Your Chemo Drugs?

Before Oct. 31, 2012, I would have probably guessed that desensitization was a process invented by mental health professionals to make really sensitive people less sensitive. I might have inquired about the cost to put my four-year-old son through “desensitization” so that he wouldn’t throw such a fit when he lost a game of knee hockey in our basement.

Now I know that desensitization is a life-saving process necessary to treat cancer patients like me.

Read more

Zeroing In On Dark Matter

If the human genome – the complete set of  DNA blueprints in a cell for building a human being — is truly “the book of life, ”  as it has been called, then 99 percent of life’s book is gobbledygook.

Only 1 percent of the DNA contains genetic instructions for making the body’s proteins; most of the rest of it has no known purpose, earning it the unappealing title of “junk DNA” or the more ominous sounding “dark matter.” In addition to containing all of life’s necessary genetic instructions, the 1 percent had also been home to all known cancer-causing mutations.

Until recently.

Read more

Sequestration Could Slow the Pace of Biomedical Research

By Edward J. Benz, Jr., MD

The automatic budget cuts (or sequestration) that went into to effect as a result of the Budget Control Act of 2011, could have a chilling long-term effect on scientific research in the United States.

The automatic cuts will slash 5.1 percent – or about $1.6 billion in 2013 alone – from the budget of the National Institutes of Health (NIH), which is the principal funder of biomedical research in the United States, and the National Cancer Institute (NCI), which is a major supporter of research at Dana-Farber.

Read more

Cancer Researcher Values Teaching and Learning

By William Hahn, MD, PhD

Every year, hundreds of postdoctoral fellows and graduate students study cancer research at Dana-Farber under some of the world’s leading scientists. The Dana-Farber Postdoc and Graduate Student Affairs Office recently named the first recipient of its Mentor-of-the-Year Award: William Hahn, MD, PhD, the Institute’s deputy scientific officer and director of its Center for Cancer Genome Discovery. Here, Hahn discusses the lessons he learned from his own mentors and his efforts to instill the same principles in his own trainees.

Read more

When It Comes to Cancer, Everyone Can Help

By Jim Donovan

In 2002 my good friend died of cancer. He and I were at MIT together as undergraduates, where we shared a lot of great memories and developed a long-lasting friendship. Like most of us who walk with a loved one through a life-threatening disease, I experienced feelings of anger, sadness, and fear. I don’t have a medical background, and honestly didn’t understand some of the terminology that doctors used during the diagnosis and the treatment. This made me feel helpless. But I wanted to help.  So I discovered other ways I could support my friend.

First and foremost, I tried to keep him positive and make him as comfortable as possible. I brought him the food he liked, watched movies with him, and stayed up late talking with him when he was sad and discouraged. I also tried to bring humor to his day because, as everyone knows, laughter is powerful medicine. I spent as much time with him as I could, depending on his needs and those of his family, and made sure to plan things for the future that he could look forward to. I reassured his wife that I would do anything to help her so his most important source of strength and comfort felt supported, too. And, so he would feel as informed as possible, I researched other patients in similar positions with the same cancer, and shared what I learned about their experiences.

Read more

Do BRCA Mutations Increase a Woman’s Lifetime Cancer Risk?

By Judy Garber, MD, MPH

We know that women who inherit harmful mutations in the genes BRCA1 or BRCA2 have a sharply increased risk of developing breast and/or ovarian cancer at an early age (prior to menopause). In fact, women with inherited BRCA1 or 2 mutations are about five times more likely to develop breast cancer — and at least 10 times more likely to develop ovarian cancer — than women without such mutations, according to the National Cancer Institute.

Read more

Driving a Blood Mobile is Hard. Donating Blood is Easy

The next time you’re ready to curse the narrow, cobblestoned streets of Boston while driving, imagine being Andre Seale. Starting next month, he’ll be navigating them in a 42-foot-long vehicle with the most precious of all resources aboard: donated blood. Seale will be behind the wheel of the new Dana-Farber Cancer Institute/Brigham and Women’s Hospital … Read more

The Power of Listening to Cancer Patients

By Melissa Cochran, MS, NP

For my cancer patients, a stem cell transplant is a life-changing event. They cannot work outside the home for a full year; visits to Dana-Farber are about the only excursions allowed. No more trips to the grocery store or dinners at a favorite restaurant.

In our clinic, we have a solid team in place – physicians, nurses, social workers, and nurse practitioners like myself – working together to support and anticipate each cancer patient’s needs along the way. As you can imagine, significant physical and emotional issues can arise for our patients.

Read more